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What is the purpose of a Gastro-Retentive Drug Delivery System (GRDDS)?
To retain the dosage form in the stomach for an extended period and release the drug slowly.
Which of the following is an advantage of GRDDS?
GRDDS can be used for the treatment of peptic ulcers.
True
What is a disadvantage of GRDDS?
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Name one type of medication that can be effectively absorbed using GRDDS.
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GRDDS improves therapeutic efficacy by providing targeted therapy for ailments in the upper ___ tract.
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Study Notes
Gastro-Retentive Drug Delivery Systems (GRDDS)
- GRDDS are increasingly popular in oral drug delivery.
- They prolong drug retention in the stomach for extended-release, addressing challenges like low bioavailability.
- Techniques include magnetic fields, swelling systems, muco-adhesion, and floating systems (with or without effervescence).
- GRDDS aim to prolong gastric residence time for targeted, site-specific drug release in the upper GI tract.
Challenges of GRDDS
- Short gastric retention time (GRT) and unpredictable gastric emptying time (GET) lead to incomplete drug release and reduced efficacy.
- Achieving prolonged gastric residence time is crucial for controlled-release, site-specific oral dosage forms.
Advantages of GRDDS
- Enhanced bioavailability
- Reduced dosing frequency
- Targeted therapy for upper GI ailments
- Improved patient compliance
- Increased therapeutic efficacy
GRDDS Applications
- Improved pharmacotherapy via local drug release, increasing drug concentration at the gastric mucosa.
- Treatment of stomach and duodenal ulcers, gastritis, and esophagitis.
- Reduced risk of gastric carcinoma.
- Controlled-release antacid formulations.
- Delivery of drugs absorbed from specific GI mucosa sites (e.g., antibiotics, antivirals, antifungals).
Disadvantages of GRDDS
- Gastric retention isn't always desirable.
- Drugs with significant first-pass metabolism may not be suitable.
- Some drugs may irritate the gastric mucosa.
- GRDDS may alter systemic metabolism or bioavailability.
- Stability issues can arise in the highly acidic gastric environment.
- GRDDS may require food for delayed gastric emptying.
Factors Controlling Gastric Retention
- Density of the dosage form: Dosage forms with density lower than the gastric contents will float.
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Description
This quiz explores the concept of Gastro-Retentive Drug Delivery Systems (GRDDS), focusing on their mechanisms, challenges, and advantages in oral drug delivery. Gain insights into the techniques employed to enhance drug retention in the stomach and the implications for improved patient outcomes. Join us to test your knowledge about this innovative technology in pharmacotherapy.
