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Gastroretentive Drug Delivery Systems

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Questions and Answers

For which type of drugs is gastric retention desirable?

Drugs that are locally active in the stomach

Drugs that degrade in the intestinal or colonic environment (correct)

Drugs that have narrow absorption window in GIT

Drugs that require rapid excretion from the body

What is the primary benefit of prolonged gastric retention for drug delivery?

Faster gastric emptying

Improved bioavailability (correct)

Increased drug waste

Reduced solubility

Which drug delivery system aims to overcome limited bioavailability due to fast gastric emptying time?

Intestinal targeted drug delivery system

Colon-specific drug delivery system

Gastric retained drug delivery system (correct)

Oral immediate release drug delivery system

Which factor contributes to the limited bioavailability of conventional oral medications?

Fast gastric emptying time (GET) Signup and view all the answers

What is the primary purpose of gastroretentive drug delivery systems?

To prolong gastric residence time of drugs Signup and view all the answers

What is the primary purpose of a pulsatile drug delivery system (PDDS)?

To release the drug as a pulse after a time lag Signup and view all the answers

Which type of drugs may require a lag time in drug release in a pulsatile drug delivery system?

Peptide drugs that degrade in gastric acidic medium Signup and view all the answers

In which portion of the gastrointestinal tract (GIT) is drug release prevented when targeting a drug to the colon?

Two-thirds portion of the GIT Signup and view all the answers

Which diseases are targeted for pulsatile technology?

(e.g. hypertension and acute myocardial infarction) and colonic delivery, all of the above Signup and view all the answers

What is the key characteristic of diseases requiring chronopharmacotherapy and pulsatile drug delivery systems?

They exhibit circadian rhythms in their pathophysiology Signup and view all the answers