Gastroretentive Drug Delivery Systems
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Questions and Answers

For which type of drugs is gastric retention desirable?

  • Drugs that are locally active in the stomach
  • Drugs that degrade in the intestinal or colonic environment (correct)
  • Drugs that have narrow absorption window in GIT
  • Drugs that require rapid excretion from the body

What is the primary benefit of prolonged gastric retention for drug delivery?

  • Faster gastric emptying
  • Improved bioavailability (correct)
  • Increased drug waste
  • Reduced solubility

Which drug delivery system aims to overcome limited bioavailability due to fast gastric emptying time?

  • Intestinal targeted drug delivery system
  • Colon-specific drug delivery system
  • Gastric retained drug delivery system (correct)
  • Oral immediate release drug delivery system

Which factor contributes to the limited bioavailability of conventional oral medications?

<p>Fast gastric emptying time (GET) (B)</p> Signup and view all the answers

What is the primary purpose of gastroretentive drug delivery systems?

<p>To prolong gastric residence time of drugs (D)</p> Signup and view all the answers

What is the primary purpose of a pulsatile drug delivery system (PDDS)?

<p>To release the drug as a pulse after a time lag (D)</p> Signup and view all the answers

Which type of drugs may require a lag time in drug release in a pulsatile drug delivery system?

<p>Peptide drugs that degrade in gastric acidic medium (D)</p> Signup and view all the answers

In which portion of the gastrointestinal tract (GIT) is drug release prevented when targeting a drug to the colon?

<p>Two-thirds portion of the GIT (D)</p> Signup and view all the answers

Which diseases are targeted for pulsatile technology?

<p>(e.g. hypertension and acute myocardial infarction) and colonic delivery, all of the above (C)</p> Signup and view all the answers

What is the key characteristic of diseases requiring chronopharmacotherapy and pulsatile drug delivery systems?

<p>They exhibit circadian rhythms in their pathophysiology (D)</p> Signup and view all the answers

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