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What characterizes Intermediate or Progenitor cells in hematopoiesis?
What characterizes Intermediate or Progenitor cells in hematopoiesis?
- They develop into mature cells without any specific commitment.
- They retain their nuclei even after maturation.
- They are unipotential and committed to a specific cell line. (correct)
- They are multipotential and can develop into various cell lines.
During which period of prenatal hematopoiesis does erythropoiesis begin?
During which period of prenatal hematopoiesis does erythropoiesis begin?
- Mesoblastic Period (correct)
- Lymphoid Period
- Hepatic Period
- Myeloid Period
What is the primary site of hematopoiesis during the Hepatic Period?
What is the primary site of hematopoiesis during the Hepatic Period?
- Yolk Sac
- Spleen
- Liver (correct)
- Bone Marrow
Which type of erythroblast is formed during the Hepatic Period and contains fetal hemoglobin (HbF)?
Which type of erythroblast is formed during the Hepatic Period and contains fetal hemoglobin (HbF)?
At what stage in fetal life does the Medullary or Myeloid Period start?
At what stage in fetal life does the Medullary or Myeloid Period start?
What significant change occurs in the cells formed during the transition from definitive erythroblasts to erythropoiesis?
What significant change occurs in the cells formed during the transition from definitive erythroblasts to erythropoiesis?
What is the chief site of hematopoiesis by the end of 24 weeks of gestation?
What is the chief site of hematopoiesis by the end of 24 weeks of gestation?
Which two hemoglobin types are detected by the end of the Medullary Period?
Which two hemoglobin types are detected by the end of the Medullary Period?
What percentage of hemoglobin is formed during the reticulocytic stage?
What percentage of hemoglobin is formed during the reticulocytic stage?
How many lobes does a mature neutrophil typically have?
How many lobes does a mature neutrophil typically have?
What stage do cells undergo enucleation before becoming reticulocytes?
What stage do cells undergo enucleation before becoming reticulocytes?
What is the primary function of erythroblastic islands in the bone marrow?
What is the primary function of erythroblastic islands in the bone marrow?
What happens to chromatin structure as cells mature?
What happens to chromatin structure as cells mature?
Which of the following processes occurs during synchronistic maturation of blood cells?
Which of the following processes occurs during synchronistic maturation of blood cells?
Which of the following best describes the change in size of cells during maturation, except for megakaryocytic cells?
Which of the following best describes the change in size of cells during maturation, except for megakaryocytic cells?
What is the first stage of hemoglobin (Hb) formation during erythropoiesis?
What is the first stage of hemoglobin (Hb) formation during erythropoiesis?
Which granulocyte is characterized by retaining its stab-shaped nucleus during maturation?
Which granulocyte is characterized by retaining its stab-shaped nucleus during maturation?
What change occurs to the cytoplasm of erythrocytic cells during maturation?
What change occurs to the cytoplasm of erythrocytic cells during maturation?
What is the term used for the removal of the nucleus just before reticulocyte formation?
What is the term used for the removal of the nucleus just before reticulocyte formation?
During maturation, what feature distinguishes immature erythrocytic cells from mature ones?
During maturation, what feature distinguishes immature erythrocytic cells from mature ones?
In which type of cell are primary granules first developed during granulocyte maturation?
In which type of cell are primary granules first developed during granulocyte maturation?
What percentage of nucleated cells in the bone marrow do erythroid cells typically account for?
What percentage of nucleated cells in the bone marrow do erythroid cells typically account for?
Which stage of development is characterized by the appearance of secondary granules in granulocytes?
Which stage of development is characterized by the appearance of secondary granules in granulocytes?
What role do macrophages play in erythroblastic islands?
What role do macrophages play in erythroblastic islands?
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Study Notes
Erythroblastic Islands
- Specialized niches where erythroid precursors proliferate, differentiate, and enucleate (extrude their nucleus).
- Consist of a macrophage surrounded by developing normoblasts.
- Involves cell-cell and cell-extracellular matrix adhesion, both positive and negative regulatory feedback.
- Erythroid cells constitute 5% to 38% of nucleated cells in bone marrow.
Principles of Synchronistic Maturation
- Nucleus and cytoplasm mature simultaneously, resulting in normal, typical cells.
Cytoplasmic Changes
- Loss of Basophilia: Younger cells have higher RNA content, leading to greater affinity for basic dyes.
- Production of Cytoplasmic Granules:
- Non-specific/primary granules develop in promyelocytes.
- Secondary granules appear in early myelocytes.
- Tertiary granules emerge in late myelocytes; distinguish granulocyte types by granule color.
- Elaboration of Hemoglobin (Hb): Begins in pronormoblasts and is observed through the reticulocyte stage.
Intermediate and Mature Cells
- Intermediate (Progenitor) cells are denoted as CFU/BFU, committed to specific cell lines.
- Mature cells or precursor cells have specific functions after development.
Stages of Hematopoiesis
- Divided into pre-natal and post-natal hematopoiesis.
Pre-Natal Hematopoiesis
Mesoblastic Period
- Begins on the 14th day of gestation, peaks in the first month, lasts until the 3rd month.
- Chief site: Blood islands of the yolk sac.
- Primitive erythroblasts are formed intravascularly, megaloblastic, and retain nuclei, containing embryonic hemoglobin (Gower 1, Gower 2, Portland).
Hepatic Period
- Starts from the 5th to 7th week of gestation until birth.
- Chief site: Liver, with contributions from spleen, lymph nodes, and thymus.
- Definitive erythroblasts formed extravascularly; they extrude their nucleus and contain HbF.
- Erythropoiesis continues, and granulopoiesis begins around the 3rd month, leading to lymphopoiesis and monocytopoiesis in subsequent months.
Medullary or Myeloid Period
- Starts from the 5th month of fetal life to adulthood.
- Bone marrow becomes the chief hematopoiesis site by the 24th week (6 months), with measurable erythropoietin (EPO) and growth factors.
- Both HbA and HbF are detectable; various maturation stages of blood cells can be observed.
Post-Natal Hematopoiesis
- At the reticulocytic stage, only 35% of hemoglobin is formed; this hemoglobin serves for oxygen delivery for the erythrocyte's lifespan (about 120 days).
Nuclear Changes
- Lobulation: Granulocytes increase nuclear lobes with maturation; neutrophils generally have 2-5 lobes.
- Changes in Chromatin Structure: Nuclear chromatin transitions from fine and linear (euchromatin) to coarse and clumped (heterochromatin).
- Extrusion of Nucleus: Occurs from pronormoblast to orthochromic normoblast; enucleation happens right before reticulocyte stage.
- Reduction in Cell Size: Maturing cells decrease in size, except megakaryocytes, which increase in size.
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