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Questions and Answers
Which nutrient is essential for the synthesis of DNA and thymidine triphosphate during RBC maturation?
What is the approximate lifespan of a normal RBC?
Which condition can cause maturation failure due to poor absorption of Vitamin B12 from the GI tract?
What is the effect of folic acid deficiency on RBC morphology?
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Which nutrient deficiency can result in macrocytic megaloblastic anemia?
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What is the main function of erythropoietin?
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Which nutrient is required for the synthesis of DNA during RBC maturation?
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What is the effect of Vitamin B12 deficiency on RBC lifespan?
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Which condition can cause maturation failure due to folic acid deficiency?
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What is the effect of Vitamin B12 deficiency on RBC morphology?
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Which of the following is the function of erythrocytes?
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Where are primitive nucleated RBCs produced during embryonic life?
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At what age does the marrow of long bones become fatty and stop producing RBCs?
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Which bones continue to produce most RBCs after the age of 20?
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What is the approximate diameter of a red blood cell?
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Which of the following is involved in the development steps of erythropoiesis?
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What is the hormone responsible for regulating erythropoiesis?
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Which of the following is responsible for the formation of multiple different blood cells from the original pluripotent hematopoietic stem cells in the bone marrow?
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Which of the following is NOT a factor that controls the growth and reproduction of blood cells?
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Which of the following is a stage of differentiation of red blood cells?
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What happens to the nucleus of an orthochromatic erythroblast during differentiation into a reticulocyte?
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Which organ is mainly responsible for the production of erythropoietin?
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What is the function of erythropoietin in the body?
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What happens to the production of erythropoietin in response to hypoxia?
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Which of the following is NOT a factor that can stimulate renal erythropoietin synthesis?
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What is the effect of renal disease or nephrectomy on erythropoietin production?
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What is the most essential regulator of RBC production in the body?
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Study Notes
RBC Maturation and Erythropoiesis
- Folic acid is essential for the synthesis of DNA and thymidine triphosphate during RBC maturation.
- The approximate lifespan of a normal RBC is 120 days.
- Pernicious anemia can cause maturation failure due to poor absorption of Vitamin B12 from the GI tract.
- Folic acid deficiency affects RBC morphology, leading to macrocytic megaloblastic anemia.
- Vitamin B12 deficiency results in macrocytic megaloblastic anemia.
- Folic acid deficiency affects RBC lifespan, leading to shorter lifespan.
- Vitamin B12 deficiency affects RBC morphology, leading to macrocytic megaloblastic anemia.
Erythropoietin and Erythropoiesis
- Erythropoietin is responsible for regulating erythropoiesis.
- Erythropoietin stimulates the production of RBCs.
- The hormone erythropoietin is produced in the kidneys and stimulates RBC production in response to hypoxia.
- The main function of erythropoietin is to stimulate RBC production in response to low oxygen levels.
RBC Development and Production
- Primitive nucleated RBCs are produced during embryonic life in the yolk sac.
- The marrow of long bones becomes fatty and stops producing RBCs around age 20.
- The bones that continue to produce most RBCs after the age of 20 are the pelvis, ribs, and sternum.
- The approximate diameter of a red blood cell is 7.5 micrometers.
- Hematopoietic stem cells in the bone marrow are responsible for the formation of multiple different blood cells.
Erythropoiesis Regulation
- The hormone responsible for regulating erythropoiesis is erythropoietin.
- The kidney is mainly responsible for the production of erythropoietin.
- In response to hypoxia, the production of erythropoietin increases.
- Renal disease or nephrectomy decreases erythropoietin production.
- The most essential regulator of RBC production in the body is erythropoietin.
RBC Differentiation
- The stage of differentiation of red blood cells where the nucleus is extruded is the orthochromatic erythroblast.
- During differentiation into a reticulocyte, the nucleus of an orthochromatic erythroblast is extruded.
- The function of erythrocytes is to carry oxygen from the lungs to the body's tissues.
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Description
Take this quiz to test your knowledge on erythropoiesis, the process of red blood cell production. Explore the tissues involved, the developmental steps, and the significance of erythropoiesis.
