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Questions and Answers
Which nutrient is essential for the synthesis of DNA and thymidine triphosphate during RBC maturation?
Which nutrient is essential for the synthesis of DNA and thymidine triphosphate during RBC maturation?
What is the approximate lifespan of a normal RBC?
What is the approximate lifespan of a normal RBC?
Which condition can cause maturation failure due to poor absorption of Vitamin B12 from the GI tract?
Which condition can cause maturation failure due to poor absorption of Vitamin B12 from the GI tract?
What is the effect of folic acid deficiency on RBC morphology?
What is the effect of folic acid deficiency on RBC morphology?
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Which nutrient deficiency can result in macrocytic megaloblastic anemia?
Which nutrient deficiency can result in macrocytic megaloblastic anemia?
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What is the main function of erythropoietin?
What is the main function of erythropoietin?
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Which nutrient is required for the synthesis of DNA during RBC maturation?
Which nutrient is required for the synthesis of DNA during RBC maturation?
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What is the effect of Vitamin B12 deficiency on RBC lifespan?
What is the effect of Vitamin B12 deficiency on RBC lifespan?
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Which condition can cause maturation failure due to folic acid deficiency?
Which condition can cause maturation failure due to folic acid deficiency?
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What is the effect of Vitamin B12 deficiency on RBC morphology?
What is the effect of Vitamin B12 deficiency on RBC morphology?
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Which of the following is the function of erythrocytes?
Which of the following is the function of erythrocytes?
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Where are primitive nucleated RBCs produced during embryonic life?
Where are primitive nucleated RBCs produced during embryonic life?
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At what age does the marrow of long bones become fatty and stop producing RBCs?
At what age does the marrow of long bones become fatty and stop producing RBCs?
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Which bones continue to produce most RBCs after the age of 20?
Which bones continue to produce most RBCs after the age of 20?
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What is the approximate diameter of a red blood cell?
What is the approximate diameter of a red blood cell?
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Which of the following is involved in the development steps of erythropoiesis?
Which of the following is involved in the development steps of erythropoiesis?
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What is the hormone responsible for regulating erythropoiesis?
What is the hormone responsible for regulating erythropoiesis?
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Which of the following is responsible for the formation of multiple different blood cells from the original pluripotent hematopoietic stem cells in the bone marrow?
Which of the following is responsible for the formation of multiple different blood cells from the original pluripotent hematopoietic stem cells in the bone marrow?
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Which of the following is NOT a factor that controls the growth and reproduction of blood cells?
Which of the following is NOT a factor that controls the growth and reproduction of blood cells?
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Which of the following is a stage of differentiation of red blood cells?
Which of the following is a stage of differentiation of red blood cells?
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What happens to the nucleus of an orthochromatic erythroblast during differentiation into a reticulocyte?
What happens to the nucleus of an orthochromatic erythroblast during differentiation into a reticulocyte?
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Which organ is mainly responsible for the production of erythropoietin?
Which organ is mainly responsible for the production of erythropoietin?
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What is the function of erythropoietin in the body?
What is the function of erythropoietin in the body?
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What happens to the production of erythropoietin in response to hypoxia?
What happens to the production of erythropoietin in response to hypoxia?
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Which of the following is NOT a factor that can stimulate renal erythropoietin synthesis?
Which of the following is NOT a factor that can stimulate renal erythropoietin synthesis?
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What is the effect of renal disease or nephrectomy on erythropoietin production?
What is the effect of renal disease or nephrectomy on erythropoietin production?
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What is the most essential regulator of RBC production in the body?
What is the most essential regulator of RBC production in the body?
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Study Notes
RBC Maturation and Erythropoiesis
- Folic acid is essential for the synthesis of DNA and thymidine triphosphate during RBC maturation.
- The approximate lifespan of a normal RBC is 120 days.
- Pernicious anemia can cause maturation failure due to poor absorption of Vitamin B12 from the GI tract.
- Folic acid deficiency affects RBC morphology, leading to macrocytic megaloblastic anemia.
- Vitamin B12 deficiency results in macrocytic megaloblastic anemia.
- Folic acid deficiency affects RBC lifespan, leading to shorter lifespan.
- Vitamin B12 deficiency affects RBC morphology, leading to macrocytic megaloblastic anemia.
Erythropoietin and Erythropoiesis
- Erythropoietin is responsible for regulating erythropoiesis.
- Erythropoietin stimulates the production of RBCs.
- The hormone erythropoietin is produced in the kidneys and stimulates RBC production in response to hypoxia.
- The main function of erythropoietin is to stimulate RBC production in response to low oxygen levels.
RBC Development and Production
- Primitive nucleated RBCs are produced during embryonic life in the yolk sac.
- The marrow of long bones becomes fatty and stops producing RBCs around age 20.
- The bones that continue to produce most RBCs after the age of 20 are the pelvis, ribs, and sternum.
- The approximate diameter of a red blood cell is 7.5 micrometers.
- Hematopoietic stem cells in the bone marrow are responsible for the formation of multiple different blood cells.
Erythropoiesis Regulation
- The hormone responsible for regulating erythropoiesis is erythropoietin.
- The kidney is mainly responsible for the production of erythropoietin.
- In response to hypoxia, the production of erythropoietin increases.
- Renal disease or nephrectomy decreases erythropoietin production.
- The most essential regulator of RBC production in the body is erythropoietin.
RBC Differentiation
- The stage of differentiation of red blood cells where the nucleus is extruded is the orthochromatic erythroblast.
- During differentiation into a reticulocyte, the nucleus of an orthochromatic erythroblast is extruded.
- The function of erythrocytes is to carry oxygen from the lungs to the body's tissues.
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Description
Take this quiz to test your knowledge on erythropoiesis, the process of red blood cell production. Explore the tissues involved, the developmental steps, and the significance of erythropoiesis.
