Mastering the Intricacies of Cerebrospinal Fluid and the Blood-Brain Barrier
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Questions and Answers

Which of the following is a histological characteristic of the blood-brain barrier?

  • Polarized endothelium (correct)
  • Many fenestrations
  • Loose junctions
  • Frequent pinocytosis

Which type of molecules can easily pass through the capillary endothelium of the blood-brain barrier?

  • Protein-bound molecules
  • Large, charged molecules
  • Small, uncharged, lipid soluble molecules (correct)
  • Water molecules

What is the main function of the blood-brain barrier?

  • To regulate the flow of cerebrospinal fluid
  • To allow the passage of harmful substances into the nervous tissue
  • To facilitate the exchange of oxygen and carbon dioxide
  • To protect the brain from potentially harmful substances (correct)

Which transport system is responsible for the uptake of glucose at the blood-brain barrier?

<p>MCT (C)</p> Signup and view all the answers

What is the function of OATs at the blood-brain barrier?

<p>Transport of organic anions (C)</p> Signup and view all the answers

What are the three meninges?

<p>Dura mater, arachnoid mater, pia mater (A)</p> Signup and view all the answers

Where is cerebrospinal fluid formed?

<p>In the ventricles of the brain (B)</p> Signup and view all the answers

What is hydrocephalus?

<p>Blockage of cerebrospinal fluid flow (A)</p> Signup and view all the answers

What are the components of the blood-brain barrier?

<p>Endothelium, pericytes, astrocytes (C)</p> Signup and view all the answers

Why is a functioning blood-brain barrier important?

<p>To protect the brain from potentially harmful substances (C)</p> Signup and view all the answers

Which one of these is NOT one of the meninges?

<p>Cerebrospinal mater (B)</p> Signup and view all the answers

What is the function of cerebrospinal fluid (CSF)?

<p>All of the above (D)</p> Signup and view all the answers

Where is cerebrospinal fluid (CSF) formed?

<p>All of the above (D)</p> Signup and view all the answers

What is the role of the choroid plexus in CSF production?

<p>To produce CSF at a constant rate (A)</p> Signup and view all the answers

Which ventricle is located between the cerebellum and the dorsal surface of the hindbrain?

<p>Fourth ventricle (B)</p> Signup and view all the answers

What is the function of the blood-brain barrier?

<p>To form a selective, tight-junction barrier (C)</p> Signup and view all the answers

Which cells form a selective, tight-junction barrier in the blood-brain barrier?

<p>Astrocytes (C)</p> Signup and view all the answers

What is the role of the leaky capillaries in the blood-brain barrier?

<p>To secrete substances into the CSF (A)</p> Signup and view all the answers

What is the importance of a functioning blood-brain barrier?

<p>To protect the brain from harmful substances (A)</p> Signup and view all the answers

What is hydrocephalus?

<p>An excess buildup of CSF in the brain (C)</p> Signup and view all the answers

Which of the following is true about cerebrospinal fluid (CSF)?

<p>Turbidity of CSF indicates increased cellularity. (B)</p> Signup and view all the answers

How is CSF absorbed into the venous system?

<p>By arachnoid villi in the dural sinuses. (C)</p> Signup and view all the answers

What is the function of the blood-brain barrier?

<p>To prevent passage of blood solutes through intercellular clefts. (D)</p> Signup and view all the answers

Where is CSF initially formed?

<p>In the choroid plexuses. (A)</p> Signup and view all the answers

What causes non-communicating hydrocephalus?

<p>Obstruction to CSF flow. (D)</p> Signup and view all the answers

How does CSF flow from the lateral ventricles to the subarachnoid space?

<p>Through the foramina of Luschka. (D)</p> Signup and view all the answers

What does increased cellularity of CSF suggest?

<p>Presence of blood. (D)</p> Signup and view all the answers

Where can CSF be sampled in most veterinary species?

<p>In the lumbar spinal column. (C)</p> Signup and view all the answers

What is the function of the arachnoid villi?

<p>To absorb CSF into the venous system. (B)</p> Signup and view all the answers

What is the function of astrocytic endfeet in the blood-brain barrier?

<p>To prevent passage of blood solutes through intercellular clefts. (D)</p> Signup and view all the answers

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