Mastering the Cytochrome P450 Enzyme Family

Questions and Answers

What is the most commonly employed single-enzyme family?

Cytochrome P450 (CYP)

What are some applications of the cytochrome P450 (CYP) family?

Evaluating metabolic stability, human hepatic clearance, drug-drug interaction potential, reaction phenotyping, studying the effect of allelic variants, generating metabolites, studying enzyme structure and function

Name some individually expressed drug-metabolizing enzymes other than cytochrome P450 (CYP).

Glucuronyltransferases, sulfotransferases (STs), epoxide hydrolases, flavin monooxygenases (FMOs), glutathione S-transferases, N-acetyltransferases

What are some possible uses of other individually expressed drug-metabolizing enzymes?

<p>Evaluating metabolic stability, human hepatic clearance, drug-drug interaction potential, reaction phenotyping, studying the effect of allelic variants</p> Signup and view all the answers

Are other individually expressed drug-metabolizing enzymes used as frequently as cytochrome P450 (CYP)?

<p>No, they are used less often</p> Signup and view all the answers

Mastering the Cytochrome P450 Enzyme Family

Questions and Answers

What is the most commonly employed single-enzyme family?

What are some applications of the cytochrome P450 (CYP) family?

Name some individually expressed drug-metabolizing enzymes other than cytochrome P450 (CYP).

What are some possible uses of other individually expressed drug-metabolizing enzymes?

Are other individually expressed drug-metabolizing enzymes used as frequently as cytochrome P450 (CYP)?

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