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What is the most commonly employed single-enzyme family?
What is the most commonly employed single-enzyme family?
Cytochrome P450 (CYP)
What are some applications of the cytochrome P450 (CYP) family?
What are some applications of the cytochrome P450 (CYP) family?
Evaluating metabolic stability, human hepatic clearance, drug-drug interaction potential, reaction phenotyping, studying the effect of allelic variants, generating metabolites, studying enzyme structure and function
Name some individually expressed drug-metabolizing enzymes other than cytochrome P450 (CYP).
Name some individually expressed drug-metabolizing enzymes other than cytochrome P450 (CYP).
Glucuronyltransferases, sulfotransferases (STs), epoxide hydrolases, flavin monooxygenases (FMOs), glutathione S-transferases, N-acetyltransferases
What are some possible uses of other individually expressed drug-metabolizing enzymes?
What are some possible uses of other individually expressed drug-metabolizing enzymes?
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Are other individually expressed drug-metabolizing enzymes used as frequently as cytochrome P450 (CYP)?
Are other individually expressed drug-metabolizing enzymes used as frequently as cytochrome P450 (CYP)?
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