Pharmacogenetics Quiz

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Which population is the HLA-B*1502 test effective for?

African descent populations

All populations

European descent populations

Asian descent populations (correct)

What is the major cause of toxic epidermal necrolysis (TEN)?

Adverse effect of pharmaceuticals (correct)

Infection

Genetic mutation

Environmental factors

What is the incidence rate of toxic epidermal necrolysis (TEN) per million population per year?

15-20

1-5 (correct)

10-15

5-10

Which enzyme is responsible for the conversion of codeine to morphine in the body?

CYP2D6 Signup and view all the answers

What is the clinical relevance of genetic variation in drug metabolizing enzymes?

It can affect the conversion of codeine to morphine Signup and view all the answers

What is the role of CYP2D6 in the metabolism of tamoxifen?

It converts tamoxifen into endoxifen Signup and view all the answers

Which phase of metabolism is responsible for introducing functional groups such as -OH, -NH2, -COOH into a drug molecule?

Phase I Signup and view all the answers

Which enzyme is involved in the metabolism of more than 75% of drugs in use?

CYP3A4/5 Signup and view all the answers

Which gene is a good candidate gene for the metabolism of Mercaptopurine (Purinethol) and azathioprine?

TPMT Signup and view all the answers

Which gene influences enzyme activity and has different genotypes with varying enzyme activity levels?

TMPT Signup and view all the answers

Pharmacogenetics Quiz

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Questions and Answers

Which population is the HLA-B*1502 test effective for?

What is the major cause of toxic epidermal necrolysis (TEN)?

What is the incidence rate of toxic epidermal necrolysis (TEN) per million population per year?

Which enzyme is responsible for the conversion of codeine to morphine in the body?

What is the clinical relevance of genetic variation in drug metabolizing enzymes?

What is the role of CYP2D6 in the metabolism of tamoxifen?

Which phase of metabolism is responsible for introducing functional groups such as -OH, -NH2, -COOH into a drug molecule?

Which enzyme is involved in the metabolism of more than 75% of drugs in use?

Which gene is a good candidate gene for the metabolism of Mercaptopurine (Purinethol) and azathioprine?

Which gene influences enzyme activity and has different genotypes with varying enzyme activity levels?

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