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Questions and Answers
Which filament is composed of myosin in smooth muscle?
Which filament is composed of myosin in smooth muscle?
- Sarcomere
- Thin filament
- Tropomyosin
- Thick filament (correct)
What is the role of an increase in cytosolic Ca2+ in smooth muscle contraction?
What is the role of an increase in cytosolic Ca2+ in smooth muscle contraction?
- Prevents contraction
- Has no effect on contraction
- Causes relaxation
- Initiates contraction (correct)
How does calcium concentration in the cytosol of smooth muscle change?
How does calcium concentration in the cytosol of smooth muscle change?
- Varies between smooth muscle types (correct)
- Remains constant
- Depends on sarcomere arrangement
- Does not change
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Study Notes
Smooth Muscle Contraction
- Thick filaments in smooth muscle are composed of myosin.
- An increase in cytosolic Ca2+ triggers smooth muscle contraction by binding to calmodulin, which activates myosin light chain kinase, leading to phosphorylation of myosin and subsequent muscle contraction.
- The concentration of calcium in the cytosol of smooth muscle increases due to the release of calcium ions from the sarcoplasmic reticulum or influx of calcium through the plasma membrane.
- The increase in cytosolic calcium concentration allows for the binding of calcium to calmodulin, ultimately leading to muscle contraction.
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