29 Questions
Which protein can phosphorylate specific target proteins to affect transcription?
PKA
Which transcription factor is activated by PKA?
CREB
Which co-activator is recruited by activated CREB to further promote transcription?
CREB-binding protein (CBP)
Which kinase can phosphorylate CREB to increase transcription of genes with a CRE?
CaM Kinase
Which protein functions similarly to PKA when activated?
PKC
Which protein is activated by receptor tyrosine kinases and triggers a series of activation-viaphosphorylation reactions ending with the activation of MAP kinase?
Ras
Which pathway is a common pathway for growth factors and can activate various transcription factors, including CREB?
PI 3 Kinase AKT pathway
Which of the following can affect transcription in intracellular signaling cascades?
All of the above
What is the role of a transcription factor in gene transcription?
Binds a DNA sequence directly to affect transcription
What is the role of a co-activator/co-repressor in gene transcription?
Binds a transcription factor to affect transcription
What is the function of cAMP in intracellular signaling cascades?
Activates protein kinase
What happens when cAMP binds to protein kinase in intracellular signaling cascades?
Dissociation of catalytic and regulatory subunits
Which of the following is NOT a way in which intracellular signaling cascades can affect transcription?
Affecting protein synthesis
What is the role of an inhibitory enzyme in intracellular signaling cascades?
Shuts off the signal
Which of the following is true about the Smad pathway?
Smad forms a complex with a coSmad and travels to the nucleus to control transcription
Which of the following is true about the Wnt pathway?
Binding of β-catenin displaces the co-repressor and functions as a co-activator
Which of the following is true about the NFkB pathway?
NFkB travels to the nucleus and initiates transcription of NFkB-responsive genes
Which of the following is true about intracellular receptors?
Ligands for intracellular receptors include steroid hormones and vitamin D
Which of the following is NOT true about the JAK-STAT pathway?
STAT is a cytosolic tyrosine kinase
Which of the following is NOT true about the Wnt pathway?
Without Wnt, β-catenin is phosphorylated and targeted for destruction
Which of the following is true about intracellular receptors and transcription of specific genes?
Intracellular receptors control the transcription of specific genes by binding to a DNA sequence specific to the receptor.
What is the role of co-regulators in intracellular receptor-mediated gene transcription?
Co-regulators bind to the intracellular receptor and enhance its ability to control transcription.
Which of the following correctly describes the process of transcriptional modification by miRNA?
miRNA represses translation by base-pairing with the mRNA.
What is the role of lncRNA in gene transcription?
lncRNA suppresses gene transcription by binding to chromatin.
Which of the following is true about the location of the thyroid hormone receptor?
The thyroid hormone receptor is located in the nucleus.
What happens when a steroid hormone binds to its intracellular receptor?
The hormone displaces an inhibitory protein bound to the inactive receptor.
What is the function of hormone response elements (HREs)?
HREs modify gene transcription.
Which of the following is a common characteristic of miRNA and lncRNA?
Both miRNA and lncRNA can modulate activity of multiple protein-coding genes.
What is the role of the receptor in intracellular receptor-mediated gene transcription?
The receptor controls the transcription of specific genes by binding to a DNA sequence specific to the receptor.
This quiz tests your understanding of how an activated receptor activates a transcription factor, which then travels to the nucleus to modify gene transcription. It also covers the role of the transcription factor in shutting off the signal by regulating the transcription of inhibitory proteins.
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