Mastering the Activation and Regulation of Transcription Factors Quiz
29 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which protein can phosphorylate specific target proteins to affect transcription?

  • PKA (correct)
  • CaM Kinase
  • PKC
  • Ras

    • Which transcription factor is activated by PKA?

  • CREB (correct)
  • CaM-Kinase
  • Ras
  • CBP

    • Which co-activator is recruited by activated CREB to further promote transcription?

  • CREB-binding protein (CBP) (correct)
  • PKA
  • CaM-Kinase
  • Ras

    • Which kinase can phosphorylate CREB to increase transcription of genes with a CRE?

    <p>CaM Kinase</p> Signup and view all the answers

    Which protein functions similarly to PKA when activated?

    <p>PKC</p> Signup and view all the answers

    Which protein is activated by receptor tyrosine kinases and triggers a series of activation-viaphosphorylation reactions ending with the activation of MAP kinase?

    <p>Ras</p> Signup and view all the answers

    Which pathway is a common pathway for growth factors and can activate various transcription factors, including CREB?

    <p>PI 3 Kinase AKT pathway</p> Signup and view all the answers

    Which of the following can affect transcription in intracellular signaling cascades?

    <p>All of the above</p> Signup and view all the answers

    What is the role of a transcription factor in gene transcription?

    <p>Binds a DNA sequence directly to affect transcription</p> Signup and view all the answers

    What is the role of a co-activator/co-repressor in gene transcription?

    <p>Binds a transcription factor to affect transcription</p> Signup and view all the answers

    What is the function of cAMP in intracellular signaling cascades?

    <p>Activates protein kinase</p> Signup and view all the answers

    What happens when cAMP binds to protein kinase in intracellular signaling cascades?

    <p>Dissociation of catalytic and regulatory subunits</p> Signup and view all the answers

    Which of the following is NOT a way in which intracellular signaling cascades can affect transcription?

    <p>Affecting protein synthesis</p> Signup and view all the answers

    What is the role of an inhibitory enzyme in intracellular signaling cascades?

    <p>Shuts off the signal</p> Signup and view all the answers

    Which of the following is true about the Smad pathway?

    <p>Smad forms a complex with a coSmad and travels to the nucleus to control transcription</p> Signup and view all the answers

    Which of the following is true about the Wnt pathway?

    <p>Binding of β-catenin displaces the co-repressor and functions as a co-activator</p> Signup and view all the answers

    Which of the following is true about the NFkB pathway?

    <p>NFkB travels to the nucleus and initiates transcription of NFkB-responsive genes</p> Signup and view all the answers

    Which of the following is true about intracellular receptors?

    <p>Ligands for intracellular receptors include steroid hormones and vitamin D</p> Signup and view all the answers

    Which of the following is NOT true about the JAK-STAT pathway?

    <p>STAT is a cytosolic tyrosine kinase</p> Signup and view all the answers

    Which of the following is NOT true about the Wnt pathway?

    <p>Without Wnt, β-catenin is phosphorylated and targeted for destruction</p> Signup and view all the answers

    Which of the following is true about intracellular receptors and transcription of specific genes?

    <p>Intracellular receptors control the transcription of specific genes by binding to a DNA sequence specific to the receptor.</p> Signup and view all the answers

    What is the role of co-regulators in intracellular receptor-mediated gene transcription?

    <p>Co-regulators bind to the intracellular receptor and enhance its ability to control transcription.</p> Signup and view all the answers

    Which of the following correctly describes the process of transcriptional modification by miRNA?

    <p>miRNA represses translation by base-pairing with the mRNA.</p> Signup and view all the answers

    What is the role of lncRNA in gene transcription?

    <p>lncRNA suppresses gene transcription by binding to chromatin.</p> Signup and view all the answers

    Which of the following is true about the location of the thyroid hormone receptor?

    <p>The thyroid hormone receptor is located in the nucleus.</p> Signup and view all the answers

    What happens when a steroid hormone binds to its intracellular receptor?

    <p>The hormone displaces an inhibitory protein bound to the inactive receptor.</p> Signup and view all the answers

    What is the function of hormone response elements (HREs)?

    <p>HREs modify gene transcription.</p> Signup and view all the answers

    Which of the following is a common characteristic of miRNA and lncRNA?

    <p>Both miRNA and lncRNA can modulate activity of multiple protein-coding genes.</p> Signup and view all the answers

    What is the role of the receptor in intracellular receptor-mediated gene transcription?

    <p>The receptor controls the transcription of specific genes by binding to a DNA sequence specific to the receptor.</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser