Mastering the Activation and Regulation of Transcription Factors Quiz

Which protein can phosphorylate specific target proteins to affect transcription?

PKA (correct)
CaM Kinase
PKC
Ras

Which transcription factor is activated by PKA?

CREB (correct)
CaM-Kinase
Ras
CBP

Which co-activator is recruited by activated CREB to further promote transcription?

CREB-binding protein (CBP) (correct)
PKA
CaM-Kinase
Ras

Which kinase can phosphorylate CREB to increase transcription of genes with a CRE?

CaM Kinase (A) Signup and view all the answers

Which protein functions similarly to PKA when activated?

PKC (D) Signup and view all the answers

Which protein is activated by receptor tyrosine kinases and triggers a series of activation-viaphosphorylation reactions ending with the activation of MAP kinase?

Ras (A) Signup and view all the answers

Which pathway is a common pathway for growth factors and can activate various transcription factors, including CREB?

PI 3 Kinase AKT pathway (A) Signup and view all the answers

Which of the following can affect transcription in intracellular signaling cascades?

All of the above (D) Signup and view all the answers

What is the role of a transcription factor in gene transcription?

Binds a DNA sequence directly to affect transcription (C) Signup and view all the answers

What is the role of a co-activator/co-repressor in gene transcription?

Binds a transcription factor to affect transcription (D) Signup and view all the answers

What is the function of cAMP in intracellular signaling cascades?

Activates protein kinase (C) Signup and view all the answers

What happens when cAMP binds to protein kinase in intracellular signaling cascades?

Dissociation of catalytic and regulatory subunits (C) Signup and view all the answers

Which of the following is NOT a way in which intracellular signaling cascades can affect transcription?

Affecting protein synthesis (D) Signup and view all the answers

What is the role of an inhibitory enzyme in intracellular signaling cascades?

Shuts off the signal (A) Signup and view all the answers

Which of the following is true about the Smad pathway?

Smad forms a complex with a coSmad and travels to the nucleus to control transcription (C) Signup and view all the answers

Which of the following is true about the Wnt pathway?

Binding of β-catenin displaces the co-repressor and functions as a co-activator (B) Signup and view all the answers

Which of the following is true about the NFkB pathway?

NFkB travels to the nucleus and initiates transcription of NFkB-responsive genes (B) Signup and view all the answers

Which of the following is true about intracellular receptors?

Ligands for intracellular receptors include steroid hormones and vitamin D (A) Signup and view all the answers

Which of the following is NOT true about the JAK-STAT pathway?

STAT is a cytosolic tyrosine kinase (C) Signup and view all the answers

Which of the following is NOT true about the Wnt pathway?

Without Wnt, β-catenin is phosphorylated and targeted for destruction (D) Signup and view all the answers

Which of the following is true about intracellular receptors and transcription of specific genes?

Intracellular receptors control the transcription of specific genes by binding to a DNA sequence specific to the receptor. (B) Signup and view all the answers

What is the role of co-regulators in intracellular receptor-mediated gene transcription?

Co-regulators bind to the intracellular receptor and enhance its ability to control transcription. (D) Signup and view all the answers

Which of the following correctly describes the process of transcriptional modification by miRNA?

miRNA represses translation by base-pairing with the mRNA. (C) Signup and view all the answers

What is the role of lncRNA in gene transcription?

lncRNA suppresses gene transcription by binding to chromatin. (A) Signup and view all the answers

Which of the following is true about the location of the thyroid hormone receptor?

The thyroid hormone receptor is located in the nucleus. (A) Signup and view all the answers

What happens when a steroid hormone binds to its intracellular receptor?

The hormone displaces an inhibitory protein bound to the inactive receptor. (D) Signup and view all the answers

What is the function of hormone response elements (HREs)?

HREs modify gene transcription. (C) Signup and view all the answers

Which of the following is a common characteristic of miRNA and lncRNA?

Both miRNA and lncRNA can modulate activity of multiple protein-coding genes. (D) Signup and view all the answers

What is the role of the receptor in intracellular receptor-mediated gene transcription?

The receptor controls the transcription of specific genes by binding to a DNA sequence specific to the receptor. (D) Signup and view all the answers