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What are some of the factors that can cause the superposition principle to not apply to the pharmacokinetics of a drug after multiple dosing?
What are some of the factors that can cause the superposition principle to not apply to the pharmacokinetics of a drug after multiple dosing?
- Changes in pathophysiology, saturation of drug carrier system, enzyme induction, and enzyme inhibition (correct)
- Changes in pathophysiology, depletion of drug carrier system, enzyme induction, and enzyme inhibition
- Changes in pathophysiology, saturation of drug carrier system, enzyme induction, and enzyme destruction
- Changes in pathophysiology, depletion of drug carrier system, enzyme induction, and enzyme destruction
What is the effect of nonlinear pharmacokinetics on the predictability of plasma drug concentrations after multiple doses using the superposition principle?
What is the effect of nonlinear pharmacokinetics on the predictability of plasma drug concentrations after multiple doses using the superposition principle?
- Nonlinear pharmacokinetics generally do not have predictable plasma drug concentrations after multiple doses using the superposition principle (correct)
- Nonlinear pharmacokinetics have less predictable plasma drug concentrations after multiple doses using the superposition principle compared to linear pharmacokinetics
- Nonlinear pharmacokinetics generally have predictable plasma drug concentrations after multiple doses using the superposition principle
- Nonlinear pharmacokinetics have more predictable plasma drug concentrations after multiple doses using the superposition principle compared to linear pharmacokinetics
What is enzyme induction in pharmacokinetics?
What is enzyme induction in pharmacokinetics?
- A process by which a drug causes an increase in the activity of enzymes responsible for the transport of the drug
- A process by which a drug causes a decrease in the activity of enzymes responsible for the metabolism of the drug
- A process by which a drug causes a decrease in the activity of enzymes responsible for the transport of the drug
- A process by which a drug causes an increase in the activity of enzymes responsible for the metabolism of the drug (correct)
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