Mastering Metabolism

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Questions and Answers

According to the text, when did the Universe and Earth originate?

  • About 14 million years ago
  • About 14 quintillion years ago
  • About 14 trillion years ago
  • About 14 billion years ago (correct)

What happened as the Universe expanded and cooled?

  • The chemical elements appeared
  • The organic matter appeared
  • Stars and planetary systems were formed
  • All of the above (correct)

What did atoms associate into as the Universe expanded and cooled?

  • Inorganic materials
  • Rocks
  • Molecules
  • All of the above (correct)

Which molecule replaced RNA as the main storage of genetic information in the scenario of genetic evolution described in the text?

<p>DNA (B)</p> Signup and view all the answers

What is the term used to describe the replication of DNA with near-perfect fidelity due to the complementarity of bases?

<p>Transcription (D)</p> Signup and view all the answers

Which type of genes are believed to have been derived by gene duplication, followed by gradual changes in the sequence through mutations?

<p>Paralogous (D)</p> Signup and view all the answers

What is the term used to describe two homologous genes found in different species?

<p>Orthologous (D)</p> Signup and view all the answers

Which of the following elements plays a central role in the chemistry of life due to its small size, low electronegativity, and propensity to form covalent bonds with itself or with other elements?

<p>C (D)</p> Signup and view all the answers

Which of the following hybridizations dictates the geometry and shape of molecules in the context of carbon and other elements?

<p>sp3 (B)</p> Signup and view all the answers

Which type of stereoisomers can't be interconverted without breaking bonds and have different physical and chemical properties?

<p>Geometric isomers (B)</p> Signup and view all the answers

For a molecule with two chiral centers, how many stereoisomers can be formed?

<p>4 (D)</p> Signup and view all the answers

According to the text, what is the objective of Biochemistry?

<p>To describe the molecular logic of life (A)</p> Signup and view all the answers

According to the text, what are the common features of living organisms?

<p>All of the above (D)</p> Signup and view all the answers

According to the text, what are the smallest cells defined by the minimum number of biomolecules required to achieve all life features?

<p>Bacterial mycoplasma (B)</p> Signup and view all the answers

According to the text, what are the major components (building blocks of life) found in animal and plant cells?

<p>Carbon and other elements (A)</p> Signup and view all the answers

According to the text, what is the equation for the variation of free energy content during a chemical reaction?

<p>$\Delta G = \Delta H - T\Delta S$ (C)</p> Signup and view all the answers

What does a positive value of $\Delta G$ indicate about a chemical reaction?

<p>The reaction requires free energy and is not spontaneous. (C)</p> Signup and view all the answers

What is the relationship between equilibrium constant $K_{eq}$, standard free-energy change $\Delta G^0$, and temperature?

<p>$\Delta G^0 = -RT\ln K_{eq}$ (A)</p> Signup and view all the answers

What is the role of catalysts in chemical reactions?

<p>Catalysts increase the rate of a chemical reaction by lowering the activation free energy. (D)</p> Signup and view all the answers

Which of the following statements accurately describes the origin of the majority of chemical elements in the Universe?

<p>Chemical elements were created immediately after the Universe was formed. (C)</p> Signup and view all the answers

What is the estimated age of the Universe?

<p>14 billion years (C)</p> Signup and view all the answers

What is the primary reason for the formation of stars and planetary systems?

<p>Expansion and cooling of the Universe (A)</p> Signup and view all the answers

What is the main characteristic of organic matter?

<p>Gradual formation over time (D)</p> Signup and view all the answers

What are the building blocks of life found in animal and plant cells?

<p>Organic matter (B)</p> Signup and view all the answers

What is the role of catalysts in chemical reactions?

<p>To increase the rate of chemical reactions (A)</p> Signup and view all the answers

According to the text, what is the term used to describe two homologous genes found in the same organism and their protein products?

<p>Paralogous (B)</p> Signup and view all the answers

According to the text, what is the term used to describe two homologous genes found in different species and their protein products?

<p>Orthologous (D)</p> Signup and view all the answers

According to the text, what is the term used to describe the ability of living organisms to self-reproduce?

<p>Evolution (D)</p> Signup and view all the answers

According to the text, what is the term used to describe mutations that give organisms an advantage in a given environment and are more likely to be propagated?

<p>Natural selection (B)</p> Signup and view all the answers

According to the text, what is the term used to describe the replication of DNA with near-perfect fidelity due to the complementarity of bases?

<p>Replication (D)</p> Signup and view all the answers

According to the text, what is the term used to describe the flow of genetic information from DNA into proteins?

<p>Translation (D)</p> Signup and view all the answers

Which of the following elements is NOT mentioned as playing an important role in metabolism in the text?

<p>Zn2+ (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of carbon mentioned in the text?

<p>Propensity to form ionic bonds with other elements (C)</p> Signup and view all the answers

Which type of stereoisomers have identical physical properties and react identically with achiral reagents?

<p>Enantiomers (B)</p> Signup and view all the answers

For a molecule with three chiral centers, how many stereoisomers can be formed?

<p>6 (A)</p> Signup and view all the answers

Which of the following is an example of a diastereoisomer mentioned in the text?

<p>NutrasweetÒ (D)</p> Signup and view all the answers

What is the main role of ATP in living organisms according to the text?

<p>To store chemical energy (D)</p> Signup and view all the answers

Which of the following elements are considered 'bulk' elements in biological systems, required in large amounts?

<p>Oxygen (A)</p> Signup and view all the answers

What is the size range of the smallest cells defined by the minimum number of biomolecules required to achieve all life features?

<p>300 nm to 500 nm in diameter (A)</p> Signup and view all the answers

Which of the following is NOT a common feature of living organisms?

<p>High degree of chemical complexity and microscopic organization (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of cells?

<p>They can change over time by gradual evolution (C)</p> Signup and view all the answers

Which of the following is the study of matter in living organisms, also known as the chemistry of the living matter?

<p>Biochemistry (C)</p> Signup and view all the answers

Which of the following domains of life do organisms belong to?

<p>Bacteria, Archaea, Eukarya (A)</p> Signup and view all the answers

According to the text, what is the equation for the variation of free energy content during a chemical reaction?

<p>$\Delta G = \Delta H - T\Delta S$ (C)</p> Signup and view all the answers

What does a positive value of $\Delta G$ indicate about a chemical reaction?

<p>The reaction is not spontaneous and requires free energy. (D)</p> Signup and view all the answers

What is the relationship between equilibrium constant $K_{eq}$, standard free-energy change $\Delta G^0$, and temperature?

<p>$\Delta G^0 = -RT\ln K_{eq}$ (A)</p> Signup and view all the answers

What is the role of catalysts in chemical reactions?

<p>Catalysts increase the rate of a chemical reaction by lowering the activation energy. (D)</p> Signup and view all the answers

Which molecule replaced RNA as the main storage of genetic information in the scenario of genetic evolution described in the text?

<p>DNA (A)</p> Signup and view all the answers

According to the text, when did life on Earth arise?

<p>3.5–3.8 billion years ago (B)</p> Signup and view all the answers

True or false: The Universe was created about 14 billion years ago?

<p>True (A)</p> Signup and view all the answers

True or false: The chemical elements appeared almost immediately after the creation of the Universe?

<p>True (A)</p> Signup and view all the answers

True or false: Atoms associated into organic matter as the Universe expanded and cooled?

<p>False (B)</p> Signup and view all the answers

True or false: Stars and planetary systems were formed as the Universe expanded and cooled?

<p>True (A)</p> Signup and view all the answers

True or false: Biochemistry is the study of matter in living organisms?

<p>True (A)</p> Signup and view all the answers

True or false: Organic matter is the main characteristic of living organisms?

<p>True (A)</p> Signup and view all the answers

True or false: Earth's position in the Solar System plays a crucial role in the development of life on Earth?

<p>True (A)</p> Signup and view all the answers

True or false: The study of matter in living organisms is known as Biochemistry?

<p>True (A)</p> Signup and view all the answers

True or false: The cell is the universal building block of life?

<p>True (A)</p> Signup and view all the answers

True or false: All living organisms are multicellular?

<p>False (B)</p> Signup and view all the answers

True or false: Animal and plant cells contain unique components but are made from the same major building blocks of life?

<p>True (A)</p> Signup and view all the answers

True or false: The size of cells is solely determined by the type of cell?

<p>False (B)</p> Signup and view all the answers

True or false: Carbon is hybridized sp3, sp2, and sp bonds, which dictates the geometry and shape of molecules.

<p>True (A)</p> Signup and view all the answers

True or false: Enantiomers have identical physical properties and react identically with achiral reagents.

<p>False (B)</p> Signup and view all the answers

True or false: Diastereomers usually have more than one chiral center and different physical and chemical properties.

<p>True (A)</p> Signup and view all the answers

True or false: The number of stereoisomers for a molecule with two chiral centers is 2n = 4.

<p>True (A)</p> Signup and view all the answers

True or false: Enantiomers can elicit different biological effects, such as SSRI antidepressants.

<p>True (A)</p> Signup and view all the answers

True or false: Interactions between molecules are stereospecific, with macromolecules folding into unique binding pockets.

<p>True (A)</p> Signup and view all the answers

True or false: DNA replaced RNA as the main storage of genetic information in the scenario of genetic evolution described in the text?

<p>True (A)</p> Signup and view all the answers

True or false: RNA still occupies a central role in information flow from DNA to proteins encoded (transcription and translation)?

<p>True (A)</p> Signup and view all the answers

True or false: Mutations occur more or less randomly in DNA and RNA?

<p>True (A)</p> Signup and view all the answers

True or false: Paralogous genes are believed to have been derived by gene duplication, followed by gradual changes in the sequence through mutations?

<p>True (A)</p> Signup and view all the answers

True or false: Orthologous genes found in different species usually have the same functions in both organisms?

<p>True (A)</p> Signup and view all the answers

True or false: Molecular phylogeny derived from gene sequences is consistent and, in some cases, even more precise than the classical phylogeny based on macroscopic structures?

<p>True (A)</p> Signup and view all the answers

Willard Gibbs developed the theory of energy changes during chemical reactions: $\Delta G = \Delta H - T\Delta S$.

<p>True (A)</p> Signup and view all the answers

Thermodynamics analyzes the difference between two states (initial and final) and does not care about intermediate states, dynamics of the system.

<p>True (A)</p> Signup and view all the answers

If $\Delta G < 0$ the reaction occurs spontaneously (free energy released, exergonic process).

<p>True (A)</p> Signup and view all the answers

Physical Foundations - Energy coupling links reactions in biology (bioenergetics): chemical coupling of exergonic and endergonic reactions allows otherwise unfavorable reactions if the overall free energy is $< 0$.

<p>True (A)</p> Signup and view all the answers

Physical Foundations - Kinetics and thermodynamics are connected through the relationship between equilibrium constant $K_{eq}$, $\Delta G^0$ (standard free-energy change), and temperature: $\Delta G^0 = -RT \ln K_{eq}$.

<p>True (A)</p> Signup and view all the answers

A catalyst is a compound that increases the rate of a chemical reaction and lowers the activation free energy $\Delta G^‡$.

<p>True (A)</p> Signup and view all the answers

True or false: The chemical elements appeared almost immediately after the creation of the Universe?

<p>True (A)</p> Signup and view all the answers

True or false: All living organisms are multicellular?

<p>False (B)</p> Signup and view all the answers

True or false: Molecular phylogeny derived from gene sequences is consistent and, in some cases, even more precise than the classical phylogeny based on macroscopic structures?

<p>True (A)</p> Signup and view all the answers

True or false: The study of matter in living organisms is known as Biochemistry?

<p>True (A)</p> Signup and view all the answers

True or false: Stars and planetary systems were formed as the Universe expanded and cooled?

<p>True (A)</p> Signup and view all the answers

True or false: Enantiomers have identical physical properties and react identically with achiral reagents.

<p>False (B)</p> Signup and view all the answers

True or false: Earth is placed at an optimal position in the Solar System in terms of exposure to the Sun?

<p>True (A)</p> Signup and view all the answers

True or false: The Earth's atmosphere and large amounts of water formed soon after Earth formation through complex chemical reactions in the Earth crust?

<p>True (A)</p> Signup and view all the answers

True or false: Life arose under the form of simple microorganisms about 4 Bn years ago?

<p>True (A)</p> Signup and view all the answers

True or false: Living organisms are made of cells?

<p>True (A)</p> Signup and view all the answers

True or false: The size of cells is determined by the type of cell, environment, function, and role in more complex systems of cells?

<p>True (A)</p> Signup and view all the answers

True or false: Organisms belong to three distinct domains of life?

<p>True (A)</p> Signup and view all the answers

True or false: Thermodynamics analyzes the difference between two states (initial and final) and does not care about intermediate states, dynamics of the system?

<p>True (A)</p> Signup and view all the answers

True or false: ATP is a 'high-energy' molecule that reacts directly with the metabolite that needs 'activation'?

<p>True (A)</p> Signup and view all the answers

True or false: Enzymatic catalysis offers acceleration under mild conditions, high specificity, and the possibility for regulation?

<p>True (A)</p> Signup and view all the answers

True or false: RNA is believed to be the initial macromolecule used for information storage?

<p>True (A)</p> Signup and view all the answers

True or false: Catalysts lower the activation free energy, but they do not alter DG°?

<p>True (A)</p> Signup and view all the answers

True or false: Biochemical pathways are controlled in order to regulate levels of metabolites?

<p>True (A)</p> Signup and view all the answers

True or false: RNA is more chemically stable than DNA?

<p>False (B)</p> Signup and view all the answers

True or false: Replication with near-perfect fidelity is possible due to the complementarity of bases in RNA?

<p>False (B)</p> Signup and view all the answers

True or false: Mutations occur randomly in DNA and RNA?

<p>True (A)</p> Signup and view all the answers

True or false: Paralogous genes are believed to have been derived through gene duplication and gradual changes in sequence?

<p>True (A)</p> Signup and view all the answers

True or false: Homologous genes found in different species are orthologous and have the same functions in both organisms?

<p>True (A)</p> Signup and view all the answers

True or false: Molecular phylogeny derived from gene sequences is more precise than classical phylogeny based on macroscopic structures?

<p>True (A)</p> Signup and view all the answers

True or false: Carbon is the only element that can form covalent bonds with itself?

<p>True (A)</p> Signup and view all the answers

True or false: Geometric isomers can be interconverted without breaking bonds?

<p>False (B)</p> Signup and view all the answers

True or false: Enantiomers have different physical and chemical properties?

<p>False (B)</p> Signup and view all the answers

True or false: Diastereomers usually have more than one chiral center?

<p>True (A)</p> Signup and view all the answers

True or false: Enantiomers are molecules with the same 3D orientation of their atoms in space?

<p>False (B)</p> Signup and view all the answers

True or false: Macromolecules fold into 3D structures with unique binding pockets?

<p>True (A)</p> Signup and view all the answers

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