Mastering Esmolol

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Which drug is contraindicated in patients with prolonged QT interval and taking quinolone antibiotics that also prolong QT interval?

Procainamide (correct)

Disopyramide

Mexiletine

Lidocaine

Which drug requires dose adjustment in renal impairment due to its renal clearance?

Procainamide

Mexiletine

Disopyramide (correct)

Lidocaine

Which drug is used for acute management of ventricular arrhythmias during myocardial infarction or digoxin toxicity?

Procainamide

Disopyramide

Mexiletine

Lidocaine (correct)

Which drug is metabolized in the liver by CYP2D6 into inactive metabolites?

Mexiletine Signup and view all the answers

Which medications are indicated in heart failure based on the neurohormonal model of HF?

Beta blockers and ACE inhibitors/ARBs Signup and view all the answers

Which types of heart failure patients should not receive beta blockers (BB)?

All of the above Signup and view all the answers

Describe the mortality benefits of ACE inhibitors/ARBs in heart failure treatment.

Reduces cardiac remodeling, improves LV function, and reduces morbidity and mortality Signup and view all the answers

Which drug is contraindicated in patients with recent decompensation or NYHA class IV heart failure and chronic atrial fibrillation?

Amiodarone Signup and view all the answers

Which drug is indicated for rapid conversion to normal sinus rhythm in paroxysmal supraventricular tachycardia?

Adenosine Signup and view all the answers

Which drug has a narrow therapeutic index and requires caution when used with 3A4 inhibitors/inducers?

Digoxin Signup and view all the answers

Which drug is the most frequent cause of drug-induced lupus?

Amiodarone Signup and view all the answers

Which antiarrhythmic agent has a half-life of 40-60 days when taken orally?

Amiodarone Signup and view all the answers

Which antiarrhythmic agent has a high incidence of QT prolongation and can cause pulmonary fibrosis at doses greater than 300mg/day?

Amiodarone Signup and view all the answers

Which antiarrhythmic agent must be initiated in a setting with continuous EKG monitoring and ability to assess CrCl for 3 days?

Sotalol Signup and view all the answers

Which antiarrhythmic agent is indicated for recent onset Afib/flutter for rapid conversion to NSR and must be discontinued as soon as arrhythmia is terminated or prolonged QT interval occurs?

Ibutilide Signup and view all the answers

Which medication in the Vaughan Williams Classification has the ability to control ventricular rate in patients with atrial fibrillation caused by enhanced sympathetic activity?

Class 2 Signup and view all the answers

Which medication in the Vaughan Williams Classification has the ability to widen the QRS complex?

Class 1c Signup and view all the answers

Which medication in the Vaughan Williams Classification delays phase 3 repolarization, resulting in marked prolongation of action potential duration (APD) and refractory period?

Class 3 Signup and view all the answers

Which medication in the Vaughan Williams Classification blocks L-type calcium channels in cardiac tissue, slowing AV and SA node conduction velocity and decreasing automaticity?

Class 4 Signup and view all the answers

Which medication is contraindicated in patients with a history of angioedema?

ACE inhibitor Signup and view all the answers

What is the mechanism of action of SGLT2 inhibitors in heart failure?

Inhibits Na-glucose cotransporter 2 in the proximal renal tubules Signup and view all the answers

Which medication combination is indicated for African Americans with NYHA class III-IV heart failure who are still symptomatic despite optimal treatment with ACE inhibitors/ARBs/ARNi and beta blockers?

Isosorbide dinitrate/hydralazine Signup and view all the answers

What is the indication for ivabradine in heart failure patients?

Reduces risk of hospitalizations for worsening heart failure Signup and view all the answers

Which medication is contraindicated in patients with a blood pressure lower than 90/50 and has an effect on mortality?

Digoxin Signup and view all the answers

What is the mechanism of action of digoxin and its inotropic effects?

Inhibits Na-K-ATPase pump= increased CO (positive inotropy) Signup and view all the answers

What are the adverse drug reactions (ADRs) of digoxin and how are ADRs enhanced?

Dizziness, mental disturbances, HA, N/V/D; Enhanced by electrolyte abnormalities and drugs that decrease K and Mg levels Signup and view all the answers

Which medications are indicated for heart failure with reduced ejection fraction (HFrEF)?

ACE inhibitors/ARBs, beta blockers Signup and view all the answers

Mastering Esmolol

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Questions and Answers

Which drug is contraindicated in patients with prolonged QT interval and taking quinolone antibiotics that also prolong QT interval?

Which drug requires dose adjustment in renal impairment due to its renal clearance?

Which drug is used for acute management of ventricular arrhythmias during myocardial infarction or digoxin toxicity?

Which drug is metabolized in the liver by CYP2D6 into inactive metabolites?

Which medications are indicated in heart failure based on the neurohormonal model of HF?

Which types of heart failure patients should not receive beta blockers (BB)?

Describe the mortality benefits of ACE inhibitors/ARBs in heart failure treatment.

Which drug is contraindicated in patients with recent decompensation or NYHA class IV heart failure and chronic atrial fibrillation?

Which drug is indicated for rapid conversion to normal sinus rhythm in paroxysmal supraventricular tachycardia?

Which drug has a narrow therapeutic index and requires caution when used with 3A4 inhibitors/inducers?

Which drug is the most frequent cause of drug-induced lupus?

Which antiarrhythmic agent has a half-life of 40-60 days when taken orally?

Which antiarrhythmic agent has a high incidence of QT prolongation and can cause pulmonary fibrosis at doses greater than 300mg/day?

Which antiarrhythmic agent must be initiated in a setting with continuous EKG monitoring and ability to assess CrCl for 3 days?

Which antiarrhythmic agent is indicated for recent onset Afib/flutter for rapid conversion to NSR and must be discontinued as soon as arrhythmia is terminated or prolonged QT interval occurs?

Which medication in the Vaughan Williams Classification has the ability to control ventricular rate in patients with atrial fibrillation caused by enhanced sympathetic activity?

Which medication in the Vaughan Williams Classification has the ability to widen the QRS complex?

Which medication in the Vaughan Williams Classification delays phase 3 repolarization, resulting in marked prolongation of action potential duration (APD) and refractory period?

Which medication in the Vaughan Williams Classification blocks L-type calcium channels in cardiac tissue, slowing AV and SA node conduction velocity and decreasing automaticity?

Which medication is contraindicated in patients with a history of angioedema?

What is the mechanism of action of SGLT2 inhibitors in heart failure?

Which medication combination is indicated for African Americans with NYHA class III-IV heart failure who are still symptomatic despite optimal treatment with ACE inhibitors/ARBs/ARNi and beta blockers?

What is the indication for ivabradine in heart failure patients?

Which medication is contraindicated in patients with a blood pressure lower than 90/50 and has an effect on mortality?

What is the mechanism of action of digoxin and its inotropic effects?

What are the adverse drug reactions (ADRs) of digoxin and how are ADRs enhanced?

Which medications are indicated for heart failure with reduced ejection fraction (HFrEF)?

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