Mastering Drug Distribution
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Questions and Answers

Which of the following factors affect drug distribution?

  • Blood flow
  • Cardiac output
  • Plasma protein binding
  • All of the above (correct)
  • Which organ has the highest blood flow?

  • Liver
  • Kidneys
  • Heart (correct)
  • Brain
  • Which protein is the predominant plasma binding protein?

  • Albumin (correct)
  • Globulin
  • Fibrinogen
  • Hemoglobin
  • What type of drugs are highly soluble in fats and non-polar solutions?

    <p>Lipophilic drugs</p> Signup and view all the answers

    What does the rate of drug distribution depend on?

    <p>Rate of delivery to tissues</p> Signup and view all the answers

    What is the blood brain barrier?

    <p>A combination of physical and functional barriers</p> Signup and view all the answers

    Can disease states affect the ability of drugs to pass through the blood brain barrier?

    <p>Yes</p> Signup and view all the answers

    Which of the following is NOT a specialized barrier or compartment that affects drug distribution?

    <p>Adipose tissue</p> Signup and view all the answers

    Which of the following is NOT a factor that can affect the volume of distribution (Vd) of a drug?

    <p>Half-life</p> Signup and view all the answers

    Which of the following molecules is LEAST likely to have a high plasma steady state concentration (Css)?

    <p>Small, water-soluble molecules</p> Signup and view all the answers

    Which of the following statements about the volume of distribution (Vd) is TRUE?

    <p>Vd is the total amount of drug in the body</p> Signup and view all the answers

    Which model of drug distribution assumes rapid mixing of the drug in plasma and rapid equilibrium with drug in extravascular tissues?

    <p>Single compartment model</p> Signup and view all the answers

    Which of the following is NOT a clinical relevance of the volume of distribution (Vd)?

    <p>Vd is always equal to the total body water</p> Signup and view all the answers

    Which of the following statements about the volume of distribution (Vd) is FALSE?

    <p>Vd is always equal to the total body water</p> Signup and view all the answers

    Which of the following is NOT a factor that can affect the time taken to reach the plasma steady state concentration (Css) of a drug?

    <p>Volume of distribution (Vd)</p> Signup and view all the answers

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