15 Questions
Which of the following factors affect drug distribution?
All of the above
Which organ has the highest blood flow?
Heart
Which protein is the predominant plasma binding protein?
Albumin
What type of drugs are highly soluble in fats and non-polar solutions?
Lipophilic drugs
What does the rate of drug distribution depend on?
Rate of delivery to tissues
What is the blood brain barrier?
A combination of physical and functional barriers
Can disease states affect the ability of drugs to pass through the blood brain barrier?
Yes
Which of the following is NOT a specialized barrier or compartment that affects drug distribution?
Adipose tissue
Which of the following is NOT a factor that can affect the volume of distribution (Vd) of a drug?
Half-life
Which of the following molecules is LEAST likely to have a high plasma steady state concentration (Css)?
Small, water-soluble molecules
Which of the following statements about the volume of distribution (Vd) is TRUE?
Vd is the total amount of drug in the body
Which model of drug distribution assumes rapid mixing of the drug in plasma and rapid equilibrium with drug in extravascular tissues?
Single compartment model
Which of the following is NOT a clinical relevance of the volume of distribution (Vd)?
Vd is always equal to the total body water
Which of the following statements about the volume of distribution (Vd) is FALSE?
Vd is always equal to the total body water
Which of the following is NOT a factor that can affect the time taken to reach the plasma steady state concentration (Css) of a drug?
Volume of distribution (Vd)
Test your knowledge on the factors that affect drug distribution and understand how it impacts the movement of drugs within the body. Explore topics such as specialised barriers, fluid compartments, and volume of distribution. Gain insights into the relative proportions of drugs in tissues and predict dose, response, and risk.
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