Pharmacology: Drug Distribution Overview

<p>High lipid solubility (B)</p> Signup and view all the answers

<p>All of the above (D)</p> Signup and view all the answers

<p>Drug distribution is essential for drug action to occur. (B)</p> Signup and view all the answers

<p>Interaction with plasma proteins. (C)</p> Signup and view all the answers

<p>It serves as a medium for drug transport to cells. (A)</p> Signup and view all the answers

<p>Molecular size (C)</p> Signup and view all the answers

<p>Skin (C)</p> Signup and view all the answers

<p>To act as a reservoir for the drug (D)</p> Signup and view all the answers

<p>Diseases like CHF (C)</p> Signup and view all the answers

<p>Bound drugs are inactive and not available for metabolism or excretion (D)</p> Signup and view all the answers

<p>Phenytoin (B)</p> Signup and view all the answers

<p>Longer duration of action (C)</p> Signup and view all the answers

<p>Drugs with high affinity for the same protein binding site can displace each other. (A)</p> Signup and view all the answers

<p>A large Vd indicates the drug is widely distributed throughout the body, not just in the blood. (A)</p> Signup and view all the answers

<p>All of the above factors influence Vd (D)</p> Signup and view all the answers

<p>Salicylates displacing sulphonylureas (B)</p> Signup and view all the answers

<p>The concentration of free drug increases. (C)</p> Signup and view all the answers

<p>A larger Vd indicates that more drug is present in the bloodstream. (B)</p> Signup and view all the answers

<p>Chloroquine (D)</p> Signup and view all the answers

<p>The BBB is easily crossed by drugs that are highly lipid-soluble. (C)</p> Signup and view all the answers

<p>Inflammation (A)</p> Signup and view all the answers

<p>They are not lipid-soluble enough to cross the cell membranes. (A)</p> Signup and view all the answers

<p>The drug will be widely distributed to various tissues. (D)</p> Signup and view all the answers

<p>A higher dose of the drug. (D)</p> Signup and view all the answers

<p>It is an incomplete barrier, allowing some water-soluble drugs to enter the fetal circulation. (C)</p> Signup and view all the answers

<p>Decreased drug efflux from the liver (B)</p> Signup and view all the answers

The movement of drug from blood to tissues for action.

The bloodstream where drugs are initially found before distribution.

Tissues and organs where drugs travel after the bloodstream.

A major factor affecting drug distribution, especially in the brain.

A protective barrier that restricts certain drugs from entering the brain.

The accumulation of drugs in cells due to ionization differences.

The process of moving drugs into cells against a concentration gradient.

The distribution of water in various body compartments affecting drug distribution.

A measure of how well a drug ionizes in solution, affecting its distribution and absorption.

Drugs distribute faster to highly perfused organs (brain, heart, liver, kidney) than to less perfused ones (muscle, skin).

Free drugs are active and available for metabolism; bound drugs are inactive, often bound to proteins like albumin.

The process where drugs bind to plasma proteins, affecting their efficacy and duration.

Includes molecular size, body mass, organ blood flow, and diseases like CHF and cirrhosis.

Drugs that bind primarily to albumin in plasma.

Drugs that bind primarily to α-1 glycoprotein in plasma.

The volume that would contain the total amount of drug in the body at plasma concentration.

When two drugs compete for the same protein binding site, affecting each other's efficacy.

A condition of low albumin levels leading to higher free drug concentration.

Highly bound drugs last longer circulating but have lower therapeutic activity.

Only the unbound portion of a drug can exert a pharmacological effect in tissues.

Drugs that concentrate in specific body tissues due to various factors.

A drug that accumulates in the heart, used for certain heart conditions.

A drug that accumulates in the liver and retina, used for treating malaria.

A mineral that accumulates in the thyroid, essential for hormone production.

An antibiotic that accumulates in bone and teeth, impacting them.

Inflammation can make the BBB leaky, allowing some drugs to enter the brain.

Lipoidal membranes that allow some drugs to pass from mother to fetus.

Water-soluble, ionized, and plasma protein-bound drugs can't cross the BBB or placental barrier.