Master the Intricate Pathways of Blood Clotting

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Which of the following is a characteristic of adult onset immune thrombocytopenic purpura (ITP)?

It is associated with autoimmune antibodies against platelets

It tends to recover spontaneously

It tends to lead to chronic disease (correct)

It is more common in children

Which of the following is a potential cause of clotting disorders?

Parainfluenza

Gram-negative sepsis

Ebola (correct)

Meningococcemia

Which of the following is a characteristic of Marburg virus?

It has a better prognosis than Ebola

It is clinically indistinguishable from Ebola

It has a fatality rate of 90% (correct)

It can be treated with a vaccine

Which of the following laboratory tests is used to evaluate hemostasis?

CBC - Platelet count Signup and view all the answers

Which of the following blood products is used for anemic patients?

RBC Signup and view all the answers

Which of the following is a function of blood vessels and platelets in controlling bleeding?

To stop flow rapidly when the system is compromised Signup and view all the answers

What is primary hemostasis?

The accumulation and adherence of platelets to the injury area Signup and view all the answers

What are the coagulation factors involved in secondary hemostasis?

Proteins and factors (Ca ions) in blood Signup and view all the answers

What is the clotting cascade?

The series of reactions that lead to the formation of a blood clot Signup and view all the answers

How can clotting be stopped using drug therapy?

By disrupting the clotting cascade Signup and view all the answers

What are the most common clinically significant disturbances of hemostasis?

Adequate numbers of platelets and normal amounts of coagulation factors Signup and view all the answers

What is the average survival of platelets in the circulation?

10 days Signup and view all the answers

What is the term used to describe small red or red-blue spots about 1-5 mm in diameter?

Petechiae Signup and view all the answers

Which of the following drugs blocks thromboxane synthesis?

NSAIDS Signup and view all the answers

Which of the following is a cause of coagulation disturbance?

Inadequate absorption of vitamin K Signup and view all the answers

What is the net effect of disseminated intravascular coagulation (DIC)?

Widespread failure of hemostasis Signup and view all the answers

Which condition is characterized by the formation of large VWF multimer chains that criss-cross blood vessels and are hyper adhesive to platelets?

Thrombotic Thrombocytopenic Purpura (TTP) Signup and view all the answers

What is the treatment for TTP

Plasma exchange Signup and view all the answers

Which of the following is a cause of thromboplastic material liberation into circulation?

All of the above Signup and view all the answers

What can inadequate synthesis of vitamin K lead to?

Inadequate absorption of vitamin K Signup and view all the answers

Which pathway is responsible for the slow, 1-6 minutes maintenance of the blood coagulation factors?

Intrinsic pathway Signup and view all the answers

Which pathway is responsible for the fast, 10-15 seconds, explosive emergency response of the blood coagulation factors?

Extrinsic pathway Signup and view all the answers

What is the goal of both the intrinsic and extrinsic pathways of the blood coagulation factors?

To form fibrin Signup and view all the answers

What is the role of thrombin in the blood coagulation process?

To convert prothrombin into thrombin Signup and view all the answers

What is the function of the fibrinolytic system in the blood coagulation process?

To dissolve clots by breaking down fibrin Signup and view all the answers

What is the role of antithrombin III in the blood coagulation process?

To inhibit factor 2a in the cascade Signup and view all the answers