Manifestations of Epilepsy and Prevalence: EEG and Psychiatric Comorbidity

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What is the main biological basis for the manifestation of epilepsy?

Imbalance of excitatory/inhibitory neurotransmission (correct)
Increased glutamate degradation
Overactivation of voltage gated cation channels
Enhanced GABAergic neurotransmission

Which neurotransmitter is NOT implicated in the biological basis of epilepsy?

Dopamine (correct)
Glutamate
GABA (Gamma-aminobutyric acid)
Serotonin

In epilepsy, epileptogenesis occurs when:

Voltage gated cation channels are overactivated
Glutamate signaling is primarily inhibitory
GABA neurotransmission is completely inhibited
The threshold for firing is reduced beyond the capability of regulatory mechanisms to prevent firing (correct)

What is the second most common neurologic disorder after stroke?

Epilepsy (C) Signup and view all the answers

What is the role of voltage gated cation channels (Na+) in the neurochemical basis of epilepsy?

They contribute to epileptogenesis when firing threshold is reduced (D) Signup and view all the answers

Which neurotransmitter imbalance is a key factor in the manifestation of epilepsy?

Glutamate-GABA imbalance (D) Signup and view all the answers

What distinguishes epilepsy from seizures?

Epilepsy is a heterogeneous symptom complex. (A) Signup and view all the answers

Which statement best describes the pharmacological management of epilepsy?

Pharmacological management focuses on preventing recurrent seizures. (A) Signup and view all the answers

What is the main purpose of identifying limitations in certain drug treatments for epilepsy?

To improve the clinical uses of antiepileptic drugs. (A) Signup and view all the answers

Which main drug group is commonly used in the pharmacological management of epilepsy?

Antiepileptic drugs (A) Signup and view all the answers

Why is it important for healthcare professionals to understand the causes of seizures in epilepsy?

To prevent potential triggers for seizure activity. (A) Signup and view all the answers

What is the significance of the International Epilepsy Day 2024?

Raising global awareness about epilepsy and supporting individuals with epilepsy. (A) Signup and view all the answers

Which brain region exhibits asynchronous firing in EEG recordings from epilepsy patients?

Temporal lobes (C) Signup and view all the answers

What is the main mechanism of action of Benzodiazepines in the treatment of epilepsy?

Binding to GABA receptors at an allosteric site (A) Signup and view all the answers

Which antiepileptic drug modulates GABA metabolism?

Vigabatrin (C) Signup and view all the answers

Loss of consciousness during an epileptic seizure is associated with abnormalities in which brain region?

Reticular formation (D) Signup and view all the answers

Which type of attack in epilepsy can be either localized or generalized?

Partial (A) Signup and view all the answers

Which cation channel modulation is associated with Ethosuximide and Valproate in the treatment of epilepsy?

Ca++ T-type channels (B) Signup and view all the answers