30 Questions
Which of the following is a characteristic feature of Alzheimer's disease?
Both plaques and tangles
Which of the following is NOT a treatment option for Alzheimer's disease?
Aducanumab
What is the cause of Alzheimer's disease?
Combination of inter-related factors
What did Dr. Alzheimer observe in his patient, Auguste Deter?
All of the above
When did researchers identify the b-amyloid protein as a factor in Alzheimer's disease?
1990s
What did British pathologists determine about Alzheimer's disease in the 1960s?
It is a disease of senility
What did Dr. Alzheimer find in Auguste Deter's brain tissue after her death?
Both plaques and tangles
Which of the following is a symptom of Alzheimer's disease?
Difficulty performing familiar tasks
Which stage of Alzheimer's disease is characterized by a loss of ability to manage instrumental activities of daily life?
Stage 4
What happens to the cortex in the brain of a person with Alzheimer's disease?
It shrivels up
What are amyloid plaques and tangles in the brain?
Both A and B
What is the role of acetylcholine in the brain?
It is a neurotransmitter involved in memory
What happens to the nucleus basalis in Alzheimer's disease?
It shrinks in size
What is the impact of loss of acetylcholine in Alzheimer's disease?
Impairment of memory
Which of the following is true about cholinergic therapy in Alzheimer's Disease?
Cholinergic therapy can worsen the behavioral symptoms of AD.
Which category of drugs is used to treat cognitive symptoms of Alzheimer's Disease?
Cholinesterase inhibitors
Which of the following drugs is NOT a cholinesterase inhibitor?
Memantine (Namenda)
Which drug has the longest half-life among the cholinesterase inhibitors?
Donepezil (Aricept)
Which drug has been discontinued in the US due to safety concerns?
Tacrine (Cognex)
Which drug has the lowest oral bioavailability among the cholinesterase inhibitors?
Rivastigmine (Exelon)
Which drug has a dual mechanism of action, including competitive inhibition of AChE and allosteric modulation of nicotinic receptors?
Galantamine (Razadyne)
Which of the following drugs has the longest half-life?
Galantamine
What is the oral bioavailability range of Galantamine?
Between 80 and 100%
Which drug is associated with liver toxicity as a side effect?
Tacrine
Which drug is available in an extended-release once-a-day tablet?
Rivastigmine
Which drug is metabolized hepatically by Cytochrome P450?
Galantamine
Which drug is associated with less frequent gastrointestinal effects when delivered through a patch?
Rivastigmine
Which drug has a dual mechanism of action involving nicotinic receptors and acetylcholine?
Galantamine
Which drug is an amyloid beta-directed antibody?
Aducanumab
Which drug has been controversially approved under the accelerated approval pathway?
Aducanumab
Test your knowledge on the treatment options for Alzheimer's Disease, including the role of cholinergic therapy and its impact on behavioral symptoms such as psychosis, agitation, dis-inhibition, apathy, and aberrant motor behavior. Explore the current understanding of managing the disease and the latest advancements in treatment approaches.
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