Managing Alzheimer's Disease
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Questions and Answers

Which of the following is a characteristic feature of Alzheimer's disease?

  • Plaques
  • Tangles
  • Both plaques and tangles (correct)
  • None of the above

    • Which of the following is NOT a treatment option for Alzheimer's disease?

  • Memantine
  • Tacrine
  • Rivastigmine
  • Aducanumab (correct)

    • What is the cause of Alzheimer's disease?

  • Genetics
  • Environmental factors
  • Combination of inter-related factors (correct)
  • All of the above

    • What did Dr. Alzheimer observe in his patient, Auguste Deter?

    <p>All of the above</p> Signup and view all the answers

    When did researchers identify the b-amyloid protein as a factor in Alzheimer's disease?

    <p>1990s</p> Signup and view all the answers

    What did British pathologists determine about Alzheimer's disease in the 1960s?

    <p>It is a disease of senility</p> Signup and view all the answers

    What did Dr. Alzheimer find in Auguste Deter's brain tissue after her death?

    <p>Both plaques and tangles</p> Signup and view all the answers

    Which of the following is a symptom of Alzheimer's disease?

    <p>Difficulty performing familiar tasks</p> Signup and view all the answers

    Which stage of Alzheimer's disease is characterized by a loss of ability to manage instrumental activities of daily life?

    <p>Stage 4</p> Signup and view all the answers

    What happens to the cortex in the brain of a person with Alzheimer's disease?

    <p>It shrivels up</p> Signup and view all the answers

    What are amyloid plaques and tangles in the brain?

    <p>Both A and B</p> Signup and view all the answers

    What is the role of acetylcholine in the brain?

    <p>It is a neurotransmitter involved in memory</p> Signup and view all the answers

    What happens to the nucleus basalis in Alzheimer's disease?

    <p>It shrinks in size</p> Signup and view all the answers

    What is the impact of loss of acetylcholine in Alzheimer's disease?

    <p>Impairment of memory</p> Signup and view all the answers

    Which of the following is true about cholinergic therapy in Alzheimer's Disease?

    <p>Cholinergic therapy can worsen the behavioral symptoms of AD.</p> Signup and view all the answers

    Which category of drugs is used to treat cognitive symptoms of Alzheimer's Disease?

    <p>Cholinesterase inhibitors</p> Signup and view all the answers

    Which of the following drugs is NOT a cholinesterase inhibitor?

    <p>Memantine (Namenda)</p> Signup and view all the answers

    Which drug has the longest half-life among the cholinesterase inhibitors?

    <p>Donepezil (Aricept)</p> Signup and view all the answers

    Which drug has been discontinued in the US due to safety concerns?

    <p>Tacrine (Cognex)</p> Signup and view all the answers

    Which drug has the lowest oral bioavailability among the cholinesterase inhibitors?

    <p>Rivastigmine (Exelon)</p> Signup and view all the answers

    Which drug has a dual mechanism of action, including competitive inhibition of AChE and allosteric modulation of nicotinic receptors?

    <p>Galantamine (Razadyne)</p> Signup and view all the answers

    Which of the following drugs has the longest half-life?

    <p>Galantamine</p> Signup and view all the answers

    What is the oral bioavailability range of Galantamine?

    <p>Between 80 and 100%</p> Signup and view all the answers

    Which drug is associated with liver toxicity as a side effect?

    <p>Tacrine</p> Signup and view all the answers

    Which drug is available in an extended-release once-a-day tablet?

    <p>Rivastigmine</p> Signup and view all the answers

    Which drug is metabolized hepatically by Cytochrome P450?

    <p>Galantamine</p> Signup and view all the answers

    Which drug is associated with less frequent gastrointestinal effects when delivered through a patch?

    <p>Rivastigmine</p> Signup and view all the answers

    Which drug has a dual mechanism of action involving nicotinic receptors and acetylcholine?

    <p>Galantamine</p> Signup and view all the answers

    Which drug is an amyloid beta-directed antibody?

    <p>Aducanumab</p> Signup and view all the answers

    Which drug has been controversially approved under the accelerated approval pathway?

    <p>Aducanumab</p> Signup and view all the answers

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