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Questions and Answers
What is the primary target of Human Immunodeficiency Virus (HIV)?
What does HIV lead to if left untreated?
What is a common limitation of Hematopoietic stem cell transplantation (HSCT)?
What is the curative modality involving the use of cells as vehicles for the delivery of genes or gene products?
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Why is it important to note that some people may not experience noticeable symptoms for several years after contracting HIV?
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What is the main function of the human immune system?
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How many different forms of PIDDs are estimated to affect people in the United States?
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What is a major clinical manifestation of PIDDs?
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Which type of laboratory test is used to identify antibody deficiencies in PIDDs?
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What is the role of inflammation and healing in the immune system?
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Study Notes
Human Immunodeficiency Virus (HIV)
- Primary target is the CD4 T lymphocytes, which are crucial for immune response.
- If left untreated, HIV progresses to Acquired Immunodeficiency Syndrome (AIDS), severely compromising the immune system.
Hematopoietic Stem Cell Transplantation (HSCT)
- A common limitation is the risk of graft-versus-host disease (GVHD), where transplanted cells attack the recipient’s body.
Gene Therapy
- Curative modality involving the use of cells as vehicles for delivering genes or gene products is known as gene therapy.
HIV Symptoms
- Important to note that some individuals may remain asymptomatic for several years, which can lead to delayed diagnosis and treatment.
Human Immune System
- Main function is to protect the body against infections and diseases by identifying and eliminating pathogens.
Primary Immunodeficiency Diseases (PIDDs)
- Approximately 330 different forms of PIDDs are estimated to affect people in the United States.
Clinical Manifestations of PIDDs
- A major clinical manifestation includes increased susceptibility to infections, which can lead to severe health complications.
Laboratory Tests for PIDDs
- Laboratory tests, such as immunoglobulin quantification, are used to identify antibody deficiencies in PIDDs.
Inflammation and Healing
- Inflammation plays a critical role in the immune system by initiating healing processes, fighting infections, and repairing tissues.
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Description
Learn about the complexity of the human immune system and the pathophysiology of Primary Immunodeficiency Disorders (PIDDs), which affect a large number of people in the United States. Gain insights into the management of patients with PIDDs.
