18 Questions
What is the primary effect of energy-dependent reuptake mechanisms in muscle cells?
Increase muscle metabolism twofold to threefold
What is the inheritance pattern of Malignant Hyperthermia in some families?
Autosomal dominant
What triggers Malignant Hyperthermia in the skeletal muscle?
Succinylcholine
Which of the following is a key triggering agent for malignant hyperthermia?
Succinylcholine
Which receptor is significantly involved in the defect leading to Malignant Hyperthermia?
Ryanodine receptor
Which of the following is not a clinical event associated with malignant hyperthermia?
Muscle relaxation
What happens to the concentration of calcium in muscle cells when Malignant Hyperthermia is initiated?
Increases
What laboratory finding is commonly observed in the context of malignant hyperthermia?
Elevated urine myoglobin levels
What is a late complication associated with malignant hyperthermia?
Cerebral edema
Which type of muscle cells show no primary defect in Malignant Hyperthermia?
Cardiac muscle cells
Which manifestation is mentioned to mimic malignant hyperthermia?
Hypovolemia
What is the result of sustained muscle contraction due to Actomysin cross-bridging in Malignant Hyperthermia?
Rigidity
What is the recommended treatment for fever in a patient with Malignant Hyperthermia?
Using cooling lavage orogastric
Which diagnostic test for Malignant Hyperthermia has 92% sensitivity and 78% specificity?
Thigh muscle biopsy
What is the standard preoperative preparation for a patient susceptible to Malignant Hyperthermia?
Changing soda lime in the anesthesia machine
How should hyperkalemia be managed in a patient with Malignant Hyperthermia?
Giving regular insulin in 50% glucose
Which of the following is NOT part of the treatment approach for acidosis in Malignant Hyperthermia?
Maintaining urine output with hydration and mannitol
What is one of the ways to prepare an anesthesia machine for a patient susceptible to Malignant Hyperthermia?
Flushing with cold IV solution for 3000ml
Learn about the energy-dependent reuptake mechanisms in muscle cells, increased metabolism, oxygen consumption, and the effects of triggering agents like volatile anesthetics in malignant hyperthermia. Understand the pathophysiology, ATP depletion, acidosis, hyperthermia, and related biochemical changes.
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