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Malignant Hyperthermia: Pathophysiology and Triggering Agents

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Malignant Hyperthermia: Pathophysiology and Triggering Agents

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Questions and Answers

What is the primary effect of energy-dependent reuptake mechanisms in muscle cells?

Increase muscle metabolism twofold to threefold (correct)

Act as a trigger for malignant hyperthermia

Decrease muscle metabolism significantly

Cause lactic acidosis

What is the inheritance pattern of Malignant Hyperthermia in some families?

Autosomal recessive

Autosomal dominant (correct)

Y-linked

X-linked dominant

What triggers Malignant Hyperthermia in the skeletal muscle?

Norepinephrine

Epinephrine

Dopamine

Succinylcholine (correct)

Which of the following is a key triggering agent for malignant hyperthermia?

Succinylcholine Signup and view all the answers

Which receptor is significantly involved in the defect leading to Malignant Hyperthermia?

Ryanodine receptor Signup and view all the answers

Which of the following is not a clinical event associated with malignant hyperthermia?

Muscle relaxation Signup and view all the answers

What happens to the concentration of calcium in muscle cells when Malignant Hyperthermia is initiated?

Increases Signup and view all the answers

What laboratory finding is commonly observed in the context of malignant hyperthermia?

Elevated urine myoglobin levels Signup and view all the answers

What is a late complication associated with malignant hyperthermia?

Cerebral edema Signup and view all the answers

Which type of muscle cells show no primary defect in Malignant Hyperthermia?

Cardiac muscle cells Signup and view all the answers

Which manifestation is mentioned to mimic malignant hyperthermia?

Hypovolemia Signup and view all the answers

What is the result of sustained muscle contraction due to Actomysin cross-bridging in Malignant Hyperthermia?

Rigidity Signup and view all the answers

What is the recommended treatment for fever in a patient with Malignant Hyperthermia?

Using cooling lavage orogastric Signup and view all the answers

Which diagnostic test for Malignant Hyperthermia has 92% sensitivity and 78% specificity?

Thigh muscle biopsy Signup and view all the answers

What is the standard preoperative preparation for a patient susceptible to Malignant Hyperthermia?

Changing soda lime in the anesthesia machine Signup and view all the answers

How should hyperkalemia be managed in a patient with Malignant Hyperthermia?

Giving regular insulin in 50% glucose Signup and view all the answers

Which of the following is NOT part of the treatment approach for acidosis in Malignant Hyperthermia?

Maintaining urine output with hydration and mannitol Signup and view all the answers

What is one of the ways to prepare an anesthesia machine for a patient susceptible to Malignant Hyperthermia?

Flushing with cold IV solution for 3000ml Signup and view all the answers