Malignant Hyperthermia: Pathophysiology and Triggering Agents
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Questions and Answers

What is the primary effect of energy-dependent reuptake mechanisms in muscle cells?

  • Increase muscle metabolism twofold to threefold (correct)
  • Act as a trigger for malignant hyperthermia
  • Decrease muscle metabolism significantly
  • Cause lactic acidosis

What is the inheritance pattern of Malignant Hyperthermia in some families?

  • Autosomal recessive
  • Autosomal dominant (correct)
  • Y-linked
  • X-linked dominant

What triggers Malignant Hyperthermia in the skeletal muscle?

  • Norepinephrine
  • Epinephrine
  • Dopamine
  • Succinylcholine (correct)

Which of the following is a key triggering agent for malignant hyperthermia?

<p>Succinylcholine (C)</p> Signup and view all the answers

Which receptor is significantly involved in the defect leading to Malignant Hyperthermia?

<p>Ryanodine receptor (A)</p> Signup and view all the answers

Which of the following is not a clinical event associated with malignant hyperthermia?

<p>Muscle relaxation (C)</p> Signup and view all the answers

What happens to the concentration of calcium in muscle cells when Malignant Hyperthermia is initiated?

<p>Increases (A)</p> Signup and view all the answers

What laboratory finding is commonly observed in the context of malignant hyperthermia?

<p>Elevated urine myoglobin levels (C)</p> Signup and view all the answers

What is a late complication associated with malignant hyperthermia?

<p>Cerebral edema (D)</p> Signup and view all the answers

Which type of muscle cells show no primary defect in Malignant Hyperthermia?

<p>Cardiac muscle cells (D)</p> Signup and view all the answers

Which manifestation is mentioned to mimic malignant hyperthermia?

<p>Hypovolemia (C)</p> Signup and view all the answers

What is the result of sustained muscle contraction due to Actomysin cross-bridging in Malignant Hyperthermia?

<p>Rigidity (D)</p> Signup and view all the answers

What is the recommended treatment for fever in a patient with Malignant Hyperthermia?

<p>Using cooling lavage orogastric (A)</p> Signup and view all the answers

Which diagnostic test for Malignant Hyperthermia has 92% sensitivity and 78% specificity?

<p>Thigh muscle biopsy (C)</p> Signup and view all the answers

What is the standard preoperative preparation for a patient susceptible to Malignant Hyperthermia?

<p>Changing soda lime in the anesthesia machine (A)</p> Signup and view all the answers

How should hyperkalemia be managed in a patient with Malignant Hyperthermia?

<p>Giving regular insulin in 50% glucose (B)</p> Signup and view all the answers

Which of the following is NOT part of the treatment approach for acidosis in Malignant Hyperthermia?

<p>Maintaining urine output with hydration and mannitol (D)</p> Signup and view all the answers

What is one of the ways to prepare an anesthesia machine for a patient susceptible to Malignant Hyperthermia?

<p>Flushing with cold IV solution for 3000ml (B)</p> Signup and view all the answers

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