Malignant Disease MCQs

Malignant Disease MCQs

• p53 Protein: Wild-type p53 is incorrectly described as being encoded by an oncogene. It is a tumor suppressor protein that regulates the cell cycle, DNA repair, and apoptosis.

• Carcinogenic Chemicals: Ascorbic acid is not a known carcinogen. Other listed chemicals (aflatoxin, benzo(a)pyrene, chrysene, and asbestos) are known carcinogens.

• Cancer Cell Characteristics: Cancer cells exhibit uncontrolled proliferation, lack contact inhibition, are insensitive to growth inhibitory signals, and exhibit anchorage-independent growth in vitro.

• Paraneoplastic Manifestations: Skin rashes are paraneoplastic manifestations. Other listed symptoms are also included in paraneoplastic manifestations: endocrine effects, hypercalcemia, and cushing's syndrome. Obstruction is not a paraneoplastic manifestation.

• Dysplasia: Dysplasia is characterized by abnormal cell division and loss of normal tissue arrangement. It's not a decrease in cell size or a conversion of one cell type to another.

• Epstein-Barr Virus (EBV): EBV is associated with Burkitt's lymphoma. This virus is not associated with the other listed cancers (breast cancer, cervical cancer, Kaposi's sarcoma, or liver cancer).

• Human Papilloma Virus (HPV): HPV is strongly linked to cervical cancer. HPV is not associated with rhabdomyosarcoma, colon cancer, or breast cancer.

• Hyperplasia: An increase in tissue mass due to an increase in the number of cells.

• Oncogene Activation: Missense mutations or deletions in proto-oncogenes can be involved in oncogene activation. Silent mutations in the coding areas of introns or exons may not.

• Local Effects of Tumor Growth: Cachexia is not a local effect of tumor growth. Compression, perforation, obstruction, and ulceration are local effects.

• Xeroderma Pigmentosum (XP): XP is an autosomal recessive genetic disorder, not exclusively a disease of female patients. XP patients are sensitive to UV light, and it's linked to nucleotide excision repair gene mutations, which increases their risk of skin cancer.

Test your knowledge on malignant diseases with these multiple-choice questions. This quiz covers topics such as p53 protein, carcinogenic chemicals, cancer cell characteristics, and paraneoplastic manifestations. Assess your understanding of dysplasia and other related concepts.