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Questions and Answers
Which of the following is an increase in tissue mass resulting from an increase in the size of its constituent cells?
Which of the following is an increase in tissue mass resulting from an increase in the size of its constituent cells?
Which mechanism might not be associated with oncogene activation?
Which mechanism might not be associated with oncogene activation?
Which of the following is not a local effect due to the growth of a tumor?
Which of the following is not a local effect due to the growth of a tumor?
Which statement about Xeroderma Pigmentosum (XP) is false?
Which statement about Xeroderma Pigmentosum (XP) is false?
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Which type of cancer is associated with a fast-growing, malignant tumor of mesenchymal origin?
Which type of cancer is associated with a fast-growing, malignant tumor of mesenchymal origin?
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Which description of active wild-type p53 protein is incorrect?
Which description of active wild-type p53 protein is incorrect?
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Which of the following chemicals is not classified as carcinogenic?
Which of the following chemicals is not classified as carcinogenic?
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Cancer cells are least likely to display which characteristic?
Cancer cells are least likely to display which characteristic?
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Which symptom is NOT a paraneoplastic manifestation of tumors?
Which symptom is NOT a paraneoplastic manifestation of tumors?
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What is the most accurate definition of dysplasia?
What is the most accurate definition of dysplasia?
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The Epstein-Barr virus is primarily associated with which condition?
The Epstein-Barr virus is primarily associated with which condition?
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Which form of cancer is Human papilloma virus (HPV) most likely associated with?
Which form of cancer is Human papilloma virus (HPV) most likely associated with?
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Which of the following is NOT a crucial role of the p53 protein?
Which of the following is NOT a crucial role of the p53 protein?
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Study Notes
Malignant Disease MCQs
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p53 Protein: Wild-type p53 is incorrectly described as being encoded by an oncogene. It is a tumor suppressor protein that regulates the cell cycle, DNA repair, and apoptosis.
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Carcinogenic Chemicals: Ascorbic acid is not a known carcinogen. Other listed chemicals (aflatoxin, benzo(a)pyrene, chrysene, and asbestos) are known carcinogens.
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Cancer Cell Characteristics: Cancer cells exhibit uncontrolled proliferation, lack contact inhibition, are insensitive to growth inhibitory signals, and exhibit anchorage-independent growth in vitro.
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Paraneoplastic Manifestations: Skin rashes are paraneoplastic manifestations. Other listed symptoms are also included in paraneoplastic manifestations: endocrine effects, hypercalcemia, and cushing's syndrome. Obstruction is not a paraneoplastic manifestation.
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Dysplasia: Dysplasia is characterized by abnormal cell division and loss of normal tissue arrangement. It's not a decrease in cell size or a conversion of one cell type to another.
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Epstein-Barr Virus (EBV): EBV is associated with Burkitt's lymphoma. This virus is not associated with the other listed cancers (breast cancer, cervical cancer, Kaposi's sarcoma, or liver cancer).
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Human Papilloma Virus (HPV): HPV is strongly linked to cervical cancer. HPV is not associated with rhabdomyosarcoma, colon cancer, or breast cancer.
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Hyperplasia: An increase in tissue mass due to an increase in the number of cells.
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Oncogene Activation: Missense mutations or deletions in proto-oncogenes can be involved in oncogene activation. Silent mutations in the coding areas of introns or exons may not.
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Local Effects of Tumor Growth: Cachexia is not a local effect of tumor growth. Compression, perforation, obstruction, and ulceration are local effects.
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Xeroderma Pigmentosum (XP): XP is an autosomal recessive genetic disorder, not exclusively a disease of female patients. XP patients are sensitive to UV light, and it's linked to nucleotide excision repair gene mutations, which increases their risk of skin cancer.
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Description
Test your knowledge on malignant diseases with these multiple-choice questions. This quiz covers topics such as p53 protein, carcinogenic chemicals, cancer cell characteristics, and paraneoplastic manifestations. Assess your understanding of dysplasia and other related concepts.
