Malignant Disease 2024-2025 Formative MCQs PDF

18/11/2024 Malignant Disease 2024-2025 formative MCQs 1 Which one of the following descriptions of active wild-type p53 protein is incorrect? a) p53 is encoded by an oncogene b) p53 regulates the cell cycle c) p53 i...

18/11/2024 Malignant Disease 2024-2025 formative MCQs 1 Which one of the following descriptions of active wild-type p53 protein is incorrect? a) p53 is encoded by an oncogene b) p53 regulates the cell cycle c) p53 is a tumour suppressor protein d) p53 regulates DNA repair e) p53 regulates the cell apoptosis 2 1  18/11/2024 Which one of the following chemicals is not carcinogenic? a) Aflatoxin b) Benzo(a)pyrene (a polycylic aromatic hydrocarbon) c) Chrysene d) Ascorbic acid e) asbestos 3 Cancer cells do not display which of the following? a) Invasion and metastasis b) Uncontrolled proliferation c) Contact-inhibited growth d) Insensitive to growth inhibitory signals e) Anchorage-independent growth in vitro 4 2  18/11/2024 Which one of the following symptoms is NOT a paraneoplastic manifestation of tumours? a) Skin rashes b) Obstruction c) Endocrine effects d) Hypercalcaemia e) Cushing’s syndrome 5 Which one of the following is the most appropriate definition of dysplasia a) A decrease in cell size and cell number b) The conversion of one type of differentiated cell into another type of differentiated cell c) Cells appear abnormal and have lost their normal tissue arrangement d) Abnormal cell division e) A type of cell death 6 3  18/11/2024 The Epstein-Barr virus is most likely associated with which of the following? a) Breast cancer b) Cervical cancer c) Kaposi’s sarcoma d) Burkitt’s lymphoma e) Liver cancer 7 Human papilloma virus (HPV) is most likely associated with which of the following? a) Rhabdomyoscarcoma b) Colon cancer c) Breast cancer d) Cervical cancer e) Skin cancer 8 4  18/11/2024 Which of the following is an increase in tissue mass resulting from an increase in the size of its constituent cells? a) Hyperplasia b) Dysplasia c) Metaplasia d) Hypertrophy e) Anaplasia 9 Which of the following mechanisms might not be associated with oncogene activation? a) Missense mutations or deletions in the coding region of proto-oncogenes b) Silent mutations in the coding regions of exons or in introns c) Chromosomal translocations d) Chromosomal amplifications e) Missense mutations or deletions in the regulatory regions of proto-oncogenes 10 5  18/11/2024 Which of the following is not local effect due to the growth of tumour? a) Compression b) Perforation c) Cachexia d) Obstruction e) Ulceration 11 Which statement about Xeroderma Pigmentosum (XP) is false? a) XP is an autosomal recessive genetic disorder b) XP is associated with mutation of nucleotide excision repair genes c) XP patients have an increased risk of developing skin cancer d) XP patients are sensitive to UV-light e) XP involves female only 12 6