15 Questions
What is the significance of the polymorphic genes of MHC molecules?
Increase the number of different MHC molecules that can present peptides to T cells
Which cell type can be targeted by CD8+ CTLs due to the expression of MHC class 1 molecules?
All nucleated cells
What is the significance of co-dominant expression of MHC genes?
Increases diversity in the MHC repertoire
Which cell types interact with CD4+ helper T lymphocytes due to the expression of MHC class 2 molecules?
Dendritic cells, macrophages, and B cells
What is the significance of codominant expression of HLA proteins?
It maximizes the number of peptides displayed by each individual
Which cells mainly express class II molecules?
Dendritic cells, macrophages, and B lymphocytes
Which cytokine can induce the expression of class II molecules on other cell types?
Interferon-γ
How many polymorphic class I genes do humans have?
Three
What is the term used for the set of MHC genes present on each chromosome?
MHC haplotype
Why are siblings often tested before unrelated individuals for their suitability as donors for transplantation?
The chance of finding an HLA match with the recipient is much greater for siblings
How are individual alleles designated in the modern terminology?
Based on molecular typing
What do the peptide-binding clefts of MHC molecules bind?
Peptides derived from protein antigens
How many peptides can each MHC molecule present at a time?
1
What is essential for the antigen display function of MHC molecules?
Broad specificity for peptide binding
Why can MHC-restricted CD4+ T cells and CD8+ T cells recognize protein antigens?
Protein antigens have the structural and charge characteristics that permit binding to the clefts of MHC molecules
Test your knowledge on the properties and significance of MHC molecules and genes, including their role in immune responses and interaction with CTLs. Explore the polymorphic genes and their impact on presenting and responding to microbial peptides.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
