Repair and Resolution of Inflammation
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Questions and Answers

Which one of the following outcomes is possible in the healing/repair process?

  • Resolution
  • Fibrosis
  • Chronic Inflammation
  • All of the above (correct)
  • Which type of inflammation occurs when injury is more severe and there is increased vascular permeability?

  • Suppurative inflammation
  • Fibrinous inflammation (correct)
  • Serous inflammation
  • Chronic inflammation
  • What is the outcome of an abscess?

  • Resolution
  • Chronic Inflammation
  • Scarring (correct)
  • Fibrosis
  • Which type of exudate is protein-rich and contains fibrinogen and other plasma proteins?

    <p>Fibrinous exudate</p> Signup and view all the answers

    What is the term for large amounts of pus (neutrophils, edema, necrotic cells) typical of inflammation?

    <p>Suppurative inflammation</p> Signup and view all the answers

    Which cells produce the components of the interstitial matrix in the extracellular matrix (ECM)?

    <p>Fibroblasts</p> Signup and view all the answers

    What is the consequence of autocrine signaling via growth factors secreted from the remaining liver tissue after partial hepatectomy?

    <p>Compensatory hyperplasia</p> Signup and view all the answers

    Which process involves the migration of endothelial cells from the original capillary to the site of the angiogenic stimulus?

    <p>Angiogenesis</p> Signup and view all the answers

    Which growth factors stimulate fibroblast recruitment and proliferation in scar formation?

    <p>PDGF, FGF-2, and TGF-beta</p> Signup and view all the answers

    What is the consequence of proteolytic degradation of the parent vessel basement membrane in angiogenesis?

    <p>Formation of new sprout</p> Signup and view all the answers

    Which cells produce the enzymes that digest the initial collagen in scar remodeling?

    <p>Fibroblasts</p> Signup and view all the answers

    Which growth factors stimulate enzyme production in scar remodeling?

    <p>All of the above</p> Signup and view all the answers

    Which type of wound healing involves regeneration predominating over fibrosis?

    <p>First intention</p> Signup and view all the answers

    What happens during the second week and beyond in first intention wound healing?

    <p>Tensile strength improves</p> Signup and view all the answers

    What accounts for the tensile strength of the repaired area in wound healing?

    <p>Collagen secretion</p> Signup and view all the answers

    Which type of inflammation is characterized by the presence of pus?

    <p>Suppurative/purulent inflammation</p> Signup and view all the answers

    What are the possible outcomes of acute inflammation?

    <p>Resolution, chronic inflammation, and repair</p> Signup and view all the answers

    Which book is suggested reading for further information on the topic?

    <p>Robbins Basic Pathology by Kumar, Abbas, and Aster</p> Signup and view all the answers

    What are the two factors that determine whether normal tissue structure and function will be restored in an area of injury and necrosis?

    <p>Capacity and growth factors</p> Signup and view all the answers

    Which type of inflammation is characterized by the formation of a granuloma?

    <p>Chronic inflammation</p> Signup and view all the answers

    Which type of inflammation is characterized by the presence of mononuclear cells such as macrophages, lymphocytes, and plasma cells?

    <p>Chronic inflammation</p> Signup and view all the answers

    Which of the following is a characteristic feature of abscesses?

    <p>All of the above</p> Signup and view all the answers

    What is the term used to describe erosion and necrosis of an area of surface epithelium with associated acute and chronic inflammation beneath the epithelial surface?

    <p>Ulceration</p> Signup and view all the answers

    Which cells are responsible for tissue destruction in chronic inflammation?

    <p>Macrophages</p> Signup and view all the answers

    What is the process by which macrophages increase in size, metabolic activity, and amount of lysosomal enzymes in response to receptor-mediated binding of cytokines and other chemical mediators?

    <p>Activation</p> Signup and view all the answers

    Which cells have the least capacity for regeneration?

    <p>Permanent cells</p> Signup and view all the answers

    What is the distinct histologic pattern of chronic inflammation that involves formation of granulomas?

    <p>Granulomatous inflammation</p> Signup and view all the answers

    What determines whether injury with substantial necrosis will result in restitution of normal structure or a permanent scar?

    <p>Both factors are equally important</p> Signup and view all the answers

    What are the two factors that determine whether injury with substantial necrosis will result in restitution of normal structure or a permanent scar?

    <p>The extent of damage to the tissue framework and the regenerative capacity of the cells in the injured tissue</p> Signup and view all the answers

    What is the role of growth factors in cell proliferation and repair?

    <p>All of the above</p> Signup and view all the answers

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