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Questions and Answers
Which of the following macromolecules is primarily broken down in the glycolytic pathway?
Which of the following macromolecules is primarily broken down in the glycolytic pathway?
Which metabolic process is responsible for synthesizing new proteins in the body?
Which metabolic process is responsible for synthesizing new proteins in the body?
Which of the following is NOT a major end product of lipid catabolism?
Which of the following is NOT a major end product of lipid catabolism?
Nucleic acid metabolism involves the synthesis and breakdown of:
Nucleic acid metabolism involves the synthesis and breakdown of:
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What is the net gain of ATP molecules produced per molecule of glucose during glycolysis?
What is the net gain of ATP molecules produced per molecule of glucose during glycolysis?
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Which enzyme catalyzes the conversion of glucose to glucose-6-phosphate in the first step of glycolysis?
Which enzyme catalyzes the conversion of glucose to glucose-6-phosphate in the first step of glycolysis?
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In the process of glycolysis, which molecule acts as the final electron acceptor to form lactate in anaerobic conditions?
In the process of glycolysis, which molecule acts as the final electron acceptor to form lactate in anaerobic conditions?
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Which step in glycolysis is considered the ‘rate-limiting step’?
Which step in glycolysis is considered the ‘rate-limiting step’?
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During glycolysis, glucose is ultimately broken down into:
During glycolysis, glucose is ultimately broken down into:
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Which enzyme in glycolysis catalyzes the substrate-level phosphorylation that produces ATP?
Which enzyme in glycolysis catalyzes the substrate-level phosphorylation that produces ATP?
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In which cellular organelle does glycolysis take place?
In which cellular organelle does glycolysis take place?
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Which metabolic pathway is responsible for generating glucose from non-carbohydrate sources?
Which metabolic pathway is responsible for generating glucose from non-carbohydrate sources?
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In aerobic conditions, pyruvate from glycolysis is converted into:
In aerobic conditions, pyruvate from glycolysis is converted into:
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How many NADH molecules are produced per molecule of glucose during glycolysis?
How many NADH molecules are produced per molecule of glucose during glycolysis?
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Which pathway involves the breakdown of triglycerides into fatty acids and glycerol?
Which pathway involves the breakdown of triglycerides into fatty acids and glycerol?
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What is the main purpose of the urea cycle in amino acid metabolism?
What is the main purpose of the urea cycle in amino acid metabolism?
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The breakdown of glucose in glycolysis produces pyruvate. In the presence of oxygen, pyruvate enters which cycle?
The breakdown of glucose in glycolysis produces pyruvate. In the presence of oxygen, pyruvate enters which cycle?
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Which coenzyme is regenerated during the conversion of pyruvate to lactate under anaerobic conditions?
Which coenzyme is regenerated during the conversion of pyruvate to lactate under anaerobic conditions?
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Which of the following molecules provides feedback inhibition to hexokinase in glycolysis?
Which of the following molecules provides feedback inhibition to hexokinase in glycolysis?
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Which enzyme in glycolysis catalyzes the cleavage of fructose-1,6-bisphosphate into two three-carbon molecules?
Which enzyme in glycolysis catalyzes the cleavage of fructose-1,6-bisphosphate into two three-carbon molecules?
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The final step of glycolysis, catalyzed by pyruvate kinase, produces pyruvate and:
The final step of glycolysis, catalyzed by pyruvate kinase, produces pyruvate and:
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During fatty acid oxidation, each cycle of beta-oxidation produces which of the following?
During fatty acid oxidation, each cycle of beta-oxidation produces which of the following?
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Which of the following is a precursor molecule for triglyceride synthesis?
Which of the following is a precursor molecule for triglyceride synthesis?
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The presence of high levels of which molecule signals cells to start glycogen synthesis?
The presence of high levels of which molecule signals cells to start glycogen synthesis?
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Which hormone stimulates the breakdown of glycogen to glucose in response to low blood sugar?
Which hormone stimulates the breakdown of glycogen to glucose in response to low blood sugar?
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Study Notes
General Overview: Macromolecule Metabolism
- Carbohydrates are broken down in glycolysis.
- Protein synthesis is responsible for creating new proteins.
- Lipid catabolism does not produce amino acids. It creates fatty acids, glycerol, and acetyl-CoA.
- Nucleic acid metabolism involves DNA and RNA synthesis and breakdown.
Carbohydrate Metabolism: Glycolysis
- Glycolysis produces 2 ATP per glucose molecule.
- Hexokinase is the enzyme that converts glucose to glucose-6-phosphate in the first step of glycolysis.
- The rate-limiting step is the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.
- Glucose is broken down into two pyruvate molecules during glycolysis.
Integration of Metabolic Pathways
- Glycolysis occurs in the cytoplasm of the cell.
- Gluconeogenesis produces glucose from noncarbohydrate sources.
- Pyruvate is converted to acetyl-CoA in aerobic conditions.
- Pyruvate is converted to lactate in anaerobic conditions. NAD+ is regenerated.
- Glucose-6-phosphate inhibits hexokinase through feedback inhibition.
- Aldolase cleaves fructose-1,6-bisphosphate to two three-carbon molecules.
- The final step of glycolysis, catalyzed by pyruvate kinase, produces pyruvate and ATP.
Lipid Metabolism
- Lipolysis breaks down triglycerides into fatty acids and glycerol.
- Acetyl-CoA, NADH, and FADH2 are produced in each cycle of beta-oxidation.
- Glycerol is used to create triglycerides.
Metabolic Regulation
- Insulin signals cells to begin glycogen synthesis.
- Glucagon causes glycogen to be broken down to glucose when blood sugar is low.
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Description
This quiz covers the essential concepts of macromolecule metabolism, including carbohydrate metabolism through glycolysis, protein synthesis, lipid catabolism, and nucleic acid metabolism. Understand the key processes and pathways that integrate these macromolecules in biological systems.
