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Lysosomal Hydrolases and Mannose 6-Phosphate

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Lysosomal Hydrolases and Mannose 6-Phosphate

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Questions and Answers

What happens to hydrolytic enzymes in the absence of mannose 6-phosphate?

They are secreted into the extracellular media and body fluids (correct)

They are transported to the endoplasmic reticulum

They are degraded in the Golgi apparatus

They are dispatched to lysosomes

Which organelle recognizes mannose-6 phosphate residues on lysosomal hydrolases?

Endoplasmic reticulum

Mitochondria

Nucleus

Golgi apparatus (correct)

What modification occurs on lysosomal hydrolases during post-translational processing?

Phosphorylation (correct)

Methylation

Glycosylation

Acetylation