Lysosomal Hydrolases and Mannose 6-Phosphate
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Questions and Answers

What happens to hydrolytic enzymes in the absence of mannose 6-phosphate?

  • They are secreted into the extracellular media and body fluids (correct)
  • They are transported to the endoplasmic reticulum
  • They are degraded in the Golgi apparatus
  • They are dispatched to lysosomes
  • Which organelle recognizes mannose-6 phosphate residues on lysosomal hydrolases?

  • Endoplasmic reticulum
  • Mitochondria
  • Nucleus
  • Golgi apparatus (correct)
  • What modification occurs on lysosomal hydrolases during post-translational processing?

  • Phosphorylation (correct)
  • Methylation
  • Glycosylation
  • Acetylation
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