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Questions and Answers
What is the description of Stage 3 in the Ann-Arbor staging of lymphomas?
What is the description of Stage 3 in the Ann-Arbor staging of lymphomas?
Burkitt's lymphoma is classified under B cell type Non-Hodgkin's lymphoma.
Burkitt's lymphoma is classified under B cell type Non-Hodgkin's lymphoma.
True
What does EBV stand for?
What does EBV stand for?
Epstein-Barr Virus
Stage 4 lymphoma indicates ________ extralymphatic involvement.
Stage 4 lymphoma indicates ________ extralymphatic involvement.
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Match the following lymphoma types with their corresponding causative organism:
Match the following lymphoma types with their corresponding causative organism:
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Study Notes
Ann-Arbor Staging of Lymphomas
- Stage 1: Involvement of a single lymph node region.
- Stage 2: Presence of two or more lymph node regions on the same side of the diaphragm.
- Stage 3: Involvement of lymph node regions on both sides of the diaphragm.
- Stage 4: Diffuse extralymphatic involvement, indicating widespread disease beyond lymph nodes.
Non-Hodgkin's Lymphoma and Causative Organisms
- Hodgkin's disease: Associated with a 100/10/40/20 rule regarding Epstein-Barr Virus (EBV) involvement.
- EBV is linked with various lymphomas, showing differing prevalence in different lymphoma types.
EBV Cases in Non-Hodgkin's Lymphoma (NHL)
- B-cell type associations:
- Burkitt's lymphoma: 100% association.
- Post organ transplant lymphoma: 70% association.
- Primary CNS lymphoma: 40% association.
- T-cell type associations:
- Extranodal NK/T-lymphoma: prevalence associated with EBV.
- Diffuse Large B-cell Lymphoma (DLBCL): 20% association.
Other Lymphomas and Disorders
- Burkitt's lymphoma: Highly aggressive B-cell lymphoma linked to EBV.
- Waldenstrom's macroglobulinemia: A type of indolent lymphoma characterized by an overproduction of IgM.
- Splenic Marginal Zone Lymphoma (MZL): Typically affects the spleen.
- MALToma (Mucosa-associated Lymphoid Tissue lymphoma): Associated with mucosal sites.
- Primary effusion lymphoma: Often occurs in patients with HIV.
- Castleman's disease: A rare disease involving an overgrowth of lymphoid tissue.
- Adult T-cell leukemia/lymphoma: Associated with Human T-Lymphotropic Virus (HTLV).
Key Terminology
- EBV: Epstein-Barr Virus, a virus implicated in several lymphoid malignancies.
- NHL: Non-Hodgkin's Lymphoma, a diverse group of blood cancers.
- DLBCL: Diffuse Large B-cell Lymphoma, the most common type of NHL.
- NK: Natural Killer cells, a type of lymphocyte involved in the immune response.
- CNS: Central Nervous System, areas of study in primary CNS lymphomas.
- MZL: Marginal Zone Lymphoma, a category of B-cell lymphomas.
- MALToma: Specific type of marginal zone lymphoma found in mucosal tissues.
- HTLV: Human T-Lymphotropic Virus, linked to certain leukemias and lymphomas.
- HCV: Hepatitis C Virus, connected with lymphoproliferative disorders.
- HIV: Human Immunodeficiency Virus, increases the risk for certain lymphomas.
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Description
Explore the stages of lymphoma classification and the role of various causative organisms, particularly in Non-Hodgkin's lymphoma. This quiz covers the Ann-Arbor staging system and highlights the impact of EBV in lymphoma cases. Test your knowledge on this critical aspect of oncology.
