Lymphoma Staging and Causative Organisms

Questions and Answers

What is the description of Stage 3 in the Ann-Arbor staging of lymphomas?

Diffuse extralymphatic involvement

Two or more node regions, same side of diaphragm

Node regions both sides of diaphragm (correct)

Single lymph node region

Burkitt's lymphoma is classified under B cell type Non-Hodgkin's lymphoma.

True

What does EBV stand for?

Epstein-Barr Virus

Stage 4 lymphoma indicates ________ extralymphatic involvement.

<p>diffuse</p> Signup and view all the answers

Match the following lymphoma types with their corresponding causative organism:

<p>Hodgkin's disease = EBV Primary CNS lymphoma = HIV Extranodal NK/T-lymphoma = HTLV Waldenstrom's macroglobulinemia = HCV</p> Signup and view all the answers

Study Notes

Ann-Arbor Staging of Lymphomas

Stage 1: Involvement of a single lymph node region.
Stage 2: Presence of two or more lymph node regions on the same side of the diaphragm.
Stage 3: Involvement of lymph node regions on both sides of the diaphragm.
Stage 4: Diffuse extralymphatic involvement, indicating widespread disease beyond lymph nodes.

Non-Hodgkin's Lymphoma and Causative Organisms

Hodgkin's disease: Associated with a 100/10/40/20 rule regarding Epstein-Barr Virus (EBV) involvement.
EBV is linked with various lymphomas, showing differing prevalence in different lymphoma types.

EBV Cases in Non-Hodgkin's Lymphoma (NHL)

B-cell type associations:
- Burkitt's lymphoma: 100% association.
- Post organ transplant lymphoma: 70% association.
- Primary CNS lymphoma: 40% association.
T-cell type associations:
- Extranodal NK/T-lymphoma: prevalence associated with EBV.
- Diffuse Large B-cell Lymphoma (DLBCL): 20% association.

Other Lymphomas and Disorders

Burkitt's lymphoma: Highly aggressive B-cell lymphoma linked to EBV.
Waldenstrom's macroglobulinemia: A type of indolent lymphoma characterized by an overproduction of IgM.
Splenic Marginal Zone Lymphoma (MZL): Typically affects the spleen.
MALToma (Mucosa-associated Lymphoid Tissue lymphoma): Associated with mucosal sites.
Primary effusion lymphoma: Often occurs in patients with HIV.
Castleman's disease: A rare disease involving an overgrowth of lymphoid tissue.
Adult T-cell leukemia/lymphoma: Associated with Human T-Lymphotropic Virus (HTLV).

Key Terminology

EBV: Epstein-Barr Virus, a virus implicated in several lymphoid malignancies.
NHL: Non-Hodgkin's Lymphoma, a diverse group of blood cancers.
DLBCL: Diffuse Large B-cell Lymphoma, the most common type of NHL.
NK: Natural Killer cells, a type of lymphocyte involved in the immune response.
CNS: Central Nervous System, areas of study in primary CNS lymphomas.
MZL: Marginal Zone Lymphoma, a category of B-cell lymphomas.
MALToma: Specific type of marginal zone lymphoma found in mucosal tissues.
HTLV: Human T-Lymphotropic Virus, linked to certain leukemias and lymphomas.
HCV: Hepatitis C Virus, connected with lymphoproliferative disorders.
HIV: Human Immunodeficiency Virus, increases the risk for certain lymphomas.

Description

Explore the stages of lymphoma classification and the role of various causative organisms, particularly in Non-Hodgkin's lymphoma. This quiz covers the Ann-Arbor staging system and highlights the impact of EBV in lymphoma cases. Test your knowledge on this critical aspect of oncology.