6.2 Lymphocytes and Their Receptors

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What distinguishes lymphocytes from one another?

Their location in the body
Their characteristic cell surface molecules (correct)
Their ability to produce antibodies
Their different sizes

Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?

WC system (correct)
AD system
CD system
BD system

What do lymphocytes possess in addition to antigen receptors?

Cytokines
Immunoglobulins
Signal transducing molecules (correct)
Complement receptors

Which type of lymphocyte plays a role in innate immunity?

Natural killer (NK) cells (C) Signup and view all the answers

What is the function of T cells in the immune system?

Regulate adaptive immunity (D) Signup and view all the answers

What is the collection of cell surface molecules on a lymphocyte called?

Immunophenotype (B) Signup and view all the answers

What is the approximate diameter of lymphocytes?

7 to 15 µm (C) Signup and view all the answers

Which organelle is found in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?

Golgi apparatus (A) Signup and view all the answers

Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

T cells (C) Signup and view all the answers

Where do T cells accumulate after leaving the thymus?

Paracortex of lymph nodes, PALS in spleen, interfollicular areas of Peyer’s patches (A) Signup and view all the answers

What type of immunity is affected due to neonatal thymectomy?

Cell-mediated immunity (B) Signup and view all the answers

Which lymphocyte type is usually larger than T or B cells and may contain cytoplasmic granules?

NK cells (C) Signup and view all the answers

What percentage of lymphocytes in blood are T cells?

60% to 80% (D) Signup and view all the answers

Which type of lymphocytes originate and mature within Peyer’s patches or in the bone marrow?

B cells (B) Signup and view all the answers

Which CD designation is found only on the T cells that recognize processed exogenous antigen?

CD4 (B) Signup and view all the answers

Which type of lymphocyte expresses more antigen receptors on its surface?

B cells (C) Signup and view all the answers

Which CD molecule is part of the IL-2 receptor?

CD25 (D) Signup and view all the answers

Which type of lymphocytes express CR1 and CR2 complement receptors?

B cells (B) Signup and view all the answers

Which integrin controls the binding of leukocytes to vascular endothelial cells?

ß2-integrins (B) Signup and view all the answers

Which selectin binds lymphocytes to high endothelial venules in lymphoid organs?

L-selectin (C) Signup and view all the answers

Which member of the Immunoglobulin superfamily (IgSF) binds to the integrin, CD11a/CD18?

ICAM-1 (A) Signup and view all the answers

Which CD designation is a receptor for MHC class II molecules?

CD4 (B) Signup and view all the answers

Which type of lymphocytes have about 200,000 to 500,000 identical antigen receptors (BCRs) on their surface?

B cells (B) Signup and view all the answers

Which molecule is a receptor for MHC class I molecules and is found only on T cells that attack and kill abnormal cells?

CD8 (C) Signup and view all the answers

Which molecule binds to the Fc region of IgG antibodies and is found on lymphocytes?

FcγR (C) Signup and view all the answers

Which molecule has not been identified as a receptor on lymphocytes for IgD antibodies?

CD16 (A) Signup and view all the answers

Which immune cell type expresses CR2 (CD21) that binds to C3d and C3bi complement proteins?

B cells (D) Signup and view all the answers

Which integrin binds leukocytes to extracellular matrix proteins like fibronectin, laminin, and collagen?

CD11a/CD18 (B) Signup and view all the answers

Which selectin binds neutrophils, T cells, and monocytes when activated during inflammation?

P-selectin (CD62P) (C) Signup and view all the answers

"Which CD molecule is part of the IL-5 receptor?"

CD125 (D) Signup and view all the answers

Which type of lymphocyte expresses CR1, binding to C3b and C4b complement proteins?

B cells (A) Signup and view all the answers

Which molecule regulates the migration of T cells into areas of inflammation?

ICAM-1 (CD54) (A) Signup and view all the answers

Which type of lymphocyte is characterized by the presence of obvious cytoplasmic granules?

NK cells (D) Signup and view all the answers

Which organelle is found in a small amount in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?

Golgi Apparatus (B) Signup and view all the answers

Which lymphocyte subpopulation accumulates in the PALS of the spleen after leaving the thymus?

T cells (A) Signup and view all the answers

Which lymphocyte subpopulation expresses more antigen receptors on its surface?

B cells (C) Signup and view all the answers

Which lymphocyte subpopulation is responsible for cell-mediated immunity?

T cells (B) Signup and view all the answers

Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

All lymphocytes (B) Signup and view all the answers

Which type of lymphocyte is responsible for cell-mediated immune responses?

T cells (C) Signup and view all the answers

Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?

WC (workshop cluster) system (B) Signup and view all the answers

What is the immunophenotype of a lymphocyte?

The collection of cell surface molecules (B) Signup and view all the answers

Which type of lymphocyte expresses more antigen receptors on its surface?

B cells (B) Signup and view all the answers

Which type of lymphocyte is usually larger than T or B cells and may contain cytoplasmic granules?

Natural killer (NK) cells (D) Signup and view all the answers

Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

Natural killer (NK) cells (C) Signup and view all the answers

Lymphocyte Markers

Cell surface molecules that distinguish lymphocytes from each other.

WC System

A system used to classify cell surface molecules on lymphocytes in domestic animals.