44 Questions
What distinguishes lymphocytes from one another?
Their characteristic cell surface molecules
Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?
WC system
What do lymphocytes possess in addition to antigen receptors?
Signal transducing molecules
Which type of lymphocyte plays a role in innate immunity?
Natural killer (NK) cells
What is the function of T cells in the immune system?
Regulate adaptive immunity
What is the collection of cell surface molecules on a lymphocyte called?
Immunophenotype
What is the approximate diameter of lymphocytes?
7 to 15 µm
Which organelle is found in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?
Golgi apparatus
Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?
T cells
Where do T cells accumulate after leaving the thymus?
Paracortex of lymph nodes, PALS in spleen, interfollicular areas of Peyer’s patches
What type of immunity is affected due to neonatal thymectomy?
Cell-mediated immunity
Which lymphocyte type is usually larger than T or B cells and may contain cytoplasmic granules?
NK cells
What percentage of lymphocytes in blood are T cells?
60% to 80%
Which type of lymphocytes originate and mature within Peyer’s patches or in the bone marrow?
B cells
Which CD designation is found only on the T cells that recognize processed exogenous antigen?
CD4
Which type of lymphocyte expresses more antigen receptors on its surface?
B cells
Which CD molecule is part of the IL-2 receptor?
CD25
Which type of lymphocytes express CR1 and CR2 complement receptors?
B cells
Which integrin controls the binding of leukocytes to vascular endothelial cells?
ß2-integrins
Which selectin binds lymphocytes to high endothelial venules in lymphoid organs?
L-selectin
Which member of the Immunoglobulin superfamily (IgSF) binds to the integrin, CD11a/CD18?
ICAM-1
Which CD designation is a receptor for MHC class II molecules?
CD4
Which type of lymphocytes have about 200,000 to 500,000 identical antigen receptors (BCRs) on their surface?
B cells
Which molecule is a receptor for MHC class I molecules and is found only on T cells that attack and kill abnormal cells?
CD8
Which molecule binds to the Fc region of IgG antibodies and is found on lymphocytes?
FcγR
Which molecule has not been identified as a receptor on lymphocytes for IgD antibodies?
CD16
Which immune cell type expresses CR2 (CD21) that binds to C3d and C3bi complement proteins?
B cells
Which integrin binds leukocytes to extracellular matrix proteins like fibronectin, laminin, and collagen?
CD11a/CD18
Which selectin binds neutrophils, T cells, and monocytes when activated during inflammation?
P-selectin (CD62P)
"Which CD molecule is part of the IL-5 receptor?"
CD125
Which type of lymphocyte expresses CR1, binding to C3b and C4b complement proteins?
B cells
Which molecule regulates the migration of T cells into areas of inflammation?
ICAM-1 (CD54)
Which type of lymphocyte is characterized by the presence of obvious cytoplasmic granules?
NK cells
Which organelle is found in a small amount in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?
Golgi Apparatus
Which lymphocyte subpopulation accumulates in the PALS of the spleen after leaving the thymus?
T cells
Which lymphocyte subpopulation expresses more antigen receptors on its surface?
B cells
Which lymphocyte subpopulation is responsible for cell-mediated immunity?
T cells
Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?
All lymphocytes
Which type of lymphocyte is responsible for cell-mediated immune responses?
T cells
Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?
WC (workshop cluster) system
What is the immunophenotype of a lymphocyte?
The collection of cell surface molecules
Which type of lymphocyte expresses more antigen receptors on its surface?
B cells
Which type of lymphocyte is usually larger than T or B cells and may contain cytoplasmic granules?
Natural killer (NK) cells
Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?
Natural killer (NK) cells
This quiz provides an overview of lymphocytes and their receptors, focusing on how these cells recognize and respond to foreign antigens. It covers the classification of lymphocytes based on cell surface molecules and the importance of antigen receptors in activating the cells. Contact Professor George Nadăș at [email protected] for more information.
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