6.2 Lymphocytes and Their Receptors
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Questions and Answers

What distinguishes lymphocytes from one another?

  • Their location in the body
  • Their characteristic cell surface molecules (correct)
  • Their ability to produce antibodies
  • Their different sizes
  • Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?

  • WC system (correct)
  • AD system
  • CD system
  • BD system
  • What do lymphocytes possess in addition to antigen receptors?

  • Cytokines
  • Immunoglobulins
  • Signal transducing molecules (correct)
  • Complement receptors
  • Which type of lymphocyte plays a role in innate immunity?

    <p>Natural killer (NK) cells</p> Signup and view all the answers

    What is the function of T cells in the immune system?

    <p>Regulate adaptive immunity</p> Signup and view all the answers

    What is the collection of cell surface molecules on a lymphocyte called?

    <p>Immunophenotype</p> Signup and view all the answers

    What is the approximate diameter of lymphocytes?

    <p>7 to 15 µm</p> Signup and view all the answers

    Which organelle is found in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?

    <p>Golgi apparatus</p> Signup and view all the answers

    Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

    <p>T cells</p> Signup and view all the answers

    Where do T cells accumulate after leaving the thymus?

    <p>Paracortex of lymph nodes, PALS in spleen, interfollicular areas of Peyer’s patches</p> Signup and view all the answers

    What type of immunity is affected due to neonatal thymectomy?

    <p>Cell-mediated immunity</p> Signup and view all the answers

    Which lymphocyte type is usually larger than T or B cells and may contain cytoplasmic granules?

    <p>NK cells</p> Signup and view all the answers

    What percentage of lymphocytes in blood are T cells?

    <p>60% to 80%</p> Signup and view all the answers

    Which type of lymphocytes originate and mature within Peyer’s patches or in the bone marrow?

    <p>B cells</p> Signup and view all the answers

    Which CD designation is found only on the T cells that recognize processed exogenous antigen?

    <p>CD4</p> Signup and view all the answers

    Which type of lymphocyte expresses more antigen receptors on its surface?

    <p>B cells</p> Signup and view all the answers

    Which CD molecule is part of the IL-2 receptor?

    <p>CD25</p> Signup and view all the answers

    Which type of lymphocytes express CR1 and CR2 complement receptors?

    <p>B cells</p> Signup and view all the answers

    Which integrin controls the binding of leukocytes to vascular endothelial cells?

    <p>ß2-integrins</p> Signup and view all the answers

    Which selectin binds lymphocytes to high endothelial venules in lymphoid organs?

    <p>L-selectin</p> Signup and view all the answers

    Which member of the Immunoglobulin superfamily (IgSF) binds to the integrin, CD11a/CD18?

    <p>ICAM-1</p> Signup and view all the answers

    Which CD designation is a receptor for MHC class II molecules?

    <p>CD4</p> Signup and view all the answers

    Which type of lymphocytes have about 200,000 to 500,000 identical antigen receptors (BCRs) on their surface?

    <p>B cells</p> Signup and view all the answers

    Which molecule is a receptor for MHC class I molecules and is found only on T cells that attack and kill abnormal cells?

    <p>CD8</p> Signup and view all the answers

    Which molecule binds to the Fc region of IgG antibodies and is found on lymphocytes?

    <p>FcγR</p> Signup and view all the answers

    Which molecule has not been identified as a receptor on lymphocytes for IgD antibodies?

    <p>CD16</p> Signup and view all the answers

    Which immune cell type expresses CR2 (CD21) that binds to C3d and C3bi complement proteins?

    <p>B cells</p> Signup and view all the answers

    Which integrin binds leukocytes to extracellular matrix proteins like fibronectin, laminin, and collagen?

    <p>CD11a/CD18</p> Signup and view all the answers

    Which selectin binds neutrophils, T cells, and monocytes when activated during inflammation?

    <p>P-selectin (CD62P)</p> Signup and view all the answers

    "Which CD molecule is part of the IL-5 receptor?"

    <p>CD125</p> Signup and view all the answers

    Which type of lymphocyte expresses CR1, binding to C3b and C4b complement proteins?

    <p>B cells</p> Signup and view all the answers

    Which molecule regulates the migration of T cells into areas of inflammation?

    <p>ICAM-1 (CD54)</p> Signup and view all the answers

    Which type of lymphocyte is characterized by the presence of obvious cytoplasmic granules?

    <p>NK cells</p> Signup and view all the answers

    Which organelle is found in a small amount in the thin cytoplasmic rim surrounding the nucleus of lymphocytes?

    <p>Golgi Apparatus</p> Signup and view all the answers

    Which lymphocyte subpopulation accumulates in the PALS of the spleen after leaving the thymus?

    <p>T cells</p> Signup and view all the answers

    Which lymphocyte subpopulation expresses more antigen receptors on its surface?

    <p>B cells</p> Signup and view all the answers

    Which lymphocyte subpopulation is responsible for cell-mediated immunity?

    <p>T cells</p> Signup and view all the answers

    Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

    <p>All lymphocytes</p> Signup and view all the answers

    Which type of lymphocyte is responsible for cell-mediated immune responses?

    <p>T cells</p> Signup and view all the answers

    Which system is used to classify cell surface molecules on lymphocytes in domestic animal species?

    <p>WC (workshop cluster) system</p> Signup and view all the answers

    What is the immunophenotype of a lymphocyte?

    <p>The collection of cell surface molecules</p> Signup and view all the answers

    Which type of lymphocyte expresses more antigen receptors on its surface?

    <p>B cells</p> Signup and view all the answers

    Which type of lymphocyte is usually larger than T or B cells and may contain cytoplasmic granules?

    <p>Natural killer (NK) cells</p> Signup and view all the answers

    Which lymphocyte subpopulation can be identified by their characteristic cell surface molecules and behavior?

    <p>Natural killer (NK) cells</p> Signup and view all the answers

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