Lymphatic System and Immunity

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Questions and Answers

What is the procedure called for the removal of infected palatine tonsils?

  • Adenoidectomy
  • Lymphadenectomy
  • Spleenectomy
  • Tonsillectomy (correct)

Which of the following lymphatic structures is most commonly associated with the groin area?

  • Thoracic nodes
  • Cervical nodes
  • Inguinal nodes (correct)
  • Axillary nodes

What type of pulp in the spleen surrounds the arteries and is involved in lymphatic functions?

  • Cortical pulp
  • Red pulp
  • Connective pulp
  • White pulp (correct)

Which area contains rapidly dividing lymphocytes within lymphatic nodules?

<p>Germinal center (A)</p> Signup and view all the answers

What is the role of macrophages found in lymphatic sinuses?

<p>Filter pathogens from lymph (A)</p> Signup and view all the answers

Where is the thymus gland located in the body?

<p>Superior mediastinum (D)</p> Signup and view all the answers

What distinguishes lymphatic nodules from lymph nodes?

<p>Lymphatic nodules are not surrounded by a capsule. (D)</p> Signup and view all the answers

What is the primary function of the spleen?

<p>Filtering blood (B)</p> Signup and view all the answers

What is the primary function of the lymphatic system in terms of fluid management?

<p>Maintenance of fluid balance (D)</p> Signup and view all the answers

Which lymphatic vessel receives lymph from the right upper limb, head, neck, and chest?

<p>Right lymphatic duct (C)</p> Signup and view all the answers

Which of the following functions is NOT performed by lymphatic vessels?

<p>Connecting tissues with arteries (C)</p> Signup and view all the answers

What are the white-appearing lymphatic fluids that pass through lacteals called?

<p>Chyle (C)</p> Signup and view all the answers

Which type of lymphatic organ is primarily involved in filtering bacteria from oral and nasal cavities?

<p>Tonsils (D)</p> Signup and view all the answers

Which of the following statements about lymphatic capillaries is incorrect?

<p>They have a one-way valve structure. (A)</p> Signup and view all the answers

Which of the following lymphatic organs can be found in the back of the mouth?

<p>Palatine tonsils (B)</p> Signup and view all the answers

What role does the contraction of skeletal muscles play in the lymphatic system?

<p>They facilitate the contraction of lymphatic vessels. (C)</p> Signup and view all the answers

What is the primary role of the medulla in lymphoid organs?

<p>Site for maturation of T cells (D)</p> Signup and view all the answers

Which of the following best describes innate immunity?

<p>First line of defense against all pathogens (A)</p> Signup and view all the answers

What initiates the movement of white blood cells toward infection sites?

<p>Chemotaxis (C)</p> Signup and view all the answers

Which of the following cells are primarily responsible for the first response to infection?

<p>Neutrophils (B)</p> Signup and view all the answers

What characterizes local inflammation?

<p>Limited to a specific area of the body (A)</p> Signup and view all the answers

Which cells are classified within the mononuclear phagocytic system?

<p>Dust cells in the lungs (A)</p> Signup and view all the answers

What is the role of natural killer cells in the immune response?

<p>To destroy infected or tumor cells (C)</p> Signup and view all the answers

What is a common result of the accumulation of neutrophils at an infection site?

<p>Formation of pus (B)</p> Signup and view all the answers

What is the primary role of pyrogens in the body?

<p>Stimulate fever production (C)</p> Signup and view all the answers

Which characteristic of adaptive immunity allows it to respond more effectively to repeated exposures to the same antigen?

<p>Memory (C)</p> Signup and view all the answers

What kind of immune response is triggered by foreign antigens?

<p>Allergic reaction (D)</p> Signup and view all the answers

Which cells are primarily responsible for producing antibodies in the adaptive immune response?

<p>B cells (A)</p> Signup and view all the answers

What is the role of cytokines in lymphocyte activation?

<p>To promote inflammation and phagocytosis (B)</p> Signup and view all the answers

What are major histocompatibility complex (MHC) molecules primarily responsible for?

<p>Binding antigens for presentation to T cells (B)</p> Signup and view all the answers

Which cytokine is released by macrophages to stimulate helper T cells?

<p>Interleukin-1 (C)</p> Signup and view all the answers

What happens during B-cell proliferation?

<p>Helper T cells stimulate B cells to divide and produce antibodies (A)</p> Signup and view all the answers

What is the role of plasma cells in antibody-mediated immunity?

<p>Produce antibodies (D)</p> Signup and view all the answers

Which part of the antibody directly interacts with the antigen?

<p>Variable region (B)</p> Signup and view all the answers

What characterizes passive immunity?

<p>Transference of immunity from another individual or source (B)</p> Signup and view all the answers

How does the constant region of an antibody function after it binds to an antigen?

<p>It activates other immune mechanisms. (B)</p> Signup and view all the answers

What defines secondary response in antibody-mediated immunity?

<p>The quick reaction due to memory B cells upon re-exposure (C)</p> Signup and view all the answers

Which of the following describes active natural immunity?

<p>Immunity developed after a natural infection by a microorganism (D)</p> Signup and view all the answers

Which cells are primarily involved in cell-mediated immunity?

<p>Cytotoxic T cells (C)</p> Signup and view all the answers

What is the main difference between natural and artificial immunity?

<p>Natural immunity is acquired through exposure while artificial immunity is deliberate. (A)</p> Signup and view all the answers

Flashcards

Lymph

Fluid that circulates in the lymphatic system, originating from interstitial fluid and eventually draining into the circulatory system.

Lipid Absorption (Lymphatic system)

The process of absorbing fats from the small intestine into the lymphatic system.

Lymphatic Capillaries

Tiny, closed-ended vessels that collect fluid from tissues and form the beginning of the lymphatic system.

Lymphatic Vessels

Larger vessels that carry lymph from lymphatic capillaries to the lymphatic organs and eventually to the circulatory system.

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Right Lymphatic Duct

Lymphatic vessel that drains lymph from the right upper limb, right head, neck, and chest, and empties into the right subclavian vein.

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Thoracic Duct

Lymphatic vessel that drains lymph from the rest of the body and empties into the left subclavian vein.

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Lymph Nodes

Small, bean-shaped organs located throughout the body that filter lymph and house immune cells.

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Tonsils

Lymphatic tissue located in the back of the mouth and top of the throat that helps filter out pathogens.

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Tonsillitis

Inflammation of the palatine tonsils, usually caused by a viral or bacterial infection.

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Tonsillectomy

Surgical removal of the palatine tonsils.

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Adenoidectomy

Surgical removal of the pharyngeal tonsils.

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Lymph Node Cortex

The outer layer of a lymph node, containing lymphatic nodules and sinuses.

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Lymphatic Nodules

Areas of tissue within lymph nodes and other organs, containing rapidly dividing lymphocytes.

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Lymphatic Sinuses

Spaces within lymph nodes, containing macrophages and fibers, where lymphatic fluid flows.

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Spleen

A large organ located in the left upper abdomen, responsible for filtering blood and storing white blood cells.

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Immunity

The ability of the body to resist damage from foreign substances such as microorganisms, harmful chemicals, and internal threats.

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Innate Immunity

A type of immunity that is nonspecific, meaning the body recognizes and destroys certain foreign substances in the same way each time it is exposed.

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Complement

A group of approximately 20 proteins found in plasma that play an important role in innate immunity.

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Interferons

Proteins that offer protection against viral infections by interfering with viral replication.

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Chemotaxis

The process by which white blood cells are drawn to a site of infection or inflammation.

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Phagocytosis

The ingestion and destruction of particles by cells called phagocytes.

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Macrophages

Monocytes that leave the blood, enter tissues, and enlarge about fivefold. They play a crucial role in phagocytosis.

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Natural Killer Cells

A type of lymphocyte produced in red bone marrow that recognizes and destroys tumor cells or virus-infected cells in general.

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Specificity in Adaptive Immunity

The ability of the immune system to recognize and target specific pathogens or substances. It allows the immune system to mount a specific response tailored to the invading threat.

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Memory in Adaptive Immunity

The ability of the immune system to remember past encounters with pathogens and mount a faster and stronger immune response upon subsequent exposure.

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Antigens

Substances that trigger an adaptive immune response. They are often foreign molecules like proteins, carbohydrates or lipids.

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Foreign Antigens

Antigens that originate from outside the body, such as bacteria, viruses, or allergens. They are not naturally found within the body.

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Self-Antigens

The body's own molecules that can mistakenly trigger an immune response, leading to autoimmune diseases. This happens when the immune system fails to recognize them as self.

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Antibody-Mediated Immunity

A type of immune response that utilizes antibodies produced by B cells to neutralize pathogens and toxins. This involves the humoral aspect of immunity, where antibodies circulate in bodily fluids.

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Cell-Mediated Immunity

A type of immune response that involves T cells directly attacking infected cells, tumor cells, or transplanted tissues. It's characterized by cellular action, rather than circulating antibodies.

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Stem Cells

Cells that give rise to all blood cells, including the lymphocytes responsible for adaptive immunity. These stem cells reside in the bone marrow.

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What are antibodies?

Antibodies are protein molecules that bind to specific antigens and initiate an immune response. They are produced by B lymphocytes, which are a type of white blood cell.

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What is the variable region of an antibody?

The variable region of an antibody is the part that binds to a specific antigen. This region varies between antibodies, allowing them to recognize and bind to different antigens.

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What is the constant region of an antibody?

The constant region of an antibody is the rest of the antibody molecule, not involved in antigen binding. It interacts with other components of the immune system to trigger immune responses.

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What are plasma cells?

Plasma cells are specialized B lymphocytes that produce and secrete large amounts of antibodies. They are essential for antibody-mediated immunity.

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What are memory B cells?

Memory B cells are long-lived B lymphocytes that retain the memory of a specific antigen. They are responsible for mounting a faster and more robust immune response upon subsequent exposure to the same antigen.

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What is active immunity?

Active immunity is when the immune system is stimulated to produce its own antibodies against an antigen. This can be acquired naturally through infection or artificially through vaccination.

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What is passive immunity?

Passive immunity is when antibodies are transferred from one person to another, providing immediate protection against a specific antigen. This can be acquired naturally from a mother to her fetus or artificially through injection of antibodies from a donor.

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What is cell-mediated immunity?

Cell-mediated immunity is a type of immune response that involves the direct killing of infected or abnormal cells by cytotoxic T lymphocytes (CTLs). It is important for fighting viral infections, tumors, and organ transplants.

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Study Notes

Lymphatic System and Immunity

  • Pathogens: Microorganisms that cause diseases or damage to tissues.
  • Lymphatic System Functions:
    • Fluid Balance: Maintains fluid balance by collecting lymph (fluid that enters lymphatic capillaries)
    • Lipid Absorption: Absorbs lipids (fats) through lacteals (lymphatic vessels in the small intestine), where lymph appears white and is called chyle.
    • Defense: Protects the body from disease.
  • Lymphatic System Anatomy:
    • Lymphatic Capillaries: Tiny, closed-ended vessels found in most tissues (except CNS, bone marrow, and epidermis). Consist of simple squamous epithelium.
    • Lymphatic Vessels: Resemble small veins, have one-way valves similar to veins. Two main ducts: Right Lymphatic Duct (drains right upper limb, right half of head, neck, and chest), and Thoracic Duct (rest of the body).
    • Lymphatic Vessel Contraction: 3 factors cause contraction—skeletal muscle activity, periodic contractions of lymphatic vessels' smooth muscle, and pressure changes in the thorax (during breathing).
    • Lymphatic Organs: Tonsils, Lymph nodes, Spleen, and Thymus.
    • Lymphatic Tissues: Lymph nodes contain lymphocytes (originating from red bone marrow) and macrophages.
  • Tonsils: Located in the back of the mouth and top of the throat. Help filter out bacteria and germs to prevent infection. 3 types: Palatine, Pharyngeal, and Lingual Tonsils.
  • Lymph Nodes: Small, bean-shaped structures along lymphatic vessels. Contain lymphocytes and macrophages to fight infection. Typically grouped in areas of the body like the groin (inguinal), armpit (axillary), and neck (cervical). Lymph nodes are surrounded by a capsule with trabeculae that divide the node into compartments. (Consist of lymphatic tissue and sinuses.)
  • Spleen: Organ roughly the size of a clenched fist, in the upper left abdominal cavity. It filters blood, has an outer capsule of dense connective tissue and smooth muscle. Consists of white pulp (lymphatic tissue around arteries) and red pulp (lymphatic tissue associated with veins). Filters blood instead of lymph.
  • Thymus: Bilobed gland in the superior mediastinum. Site of maturation for a class of lymphocytes called T cells.
  • Immunology: Body's ability to resist damage.
  • Innate Immunity: Nonspecific defense, recognizes and destroys foreign substances the same way every time.
  • Physical Barriers: Prevent microorganism entry—skin and mucous membranes.
  • Immune Mediators: Chemicals in innate immunity (examples: complements, interferons).
  • White Blood Cells: Important cellular components of immunity. Chemicals known to attract white blood cells: complement, leukotrienes, kinins, histamine.
  • Phagocytic Cells: Ingest and destroy particles—examples: neutrophils, macrophages (part of mononuclear phagocytic system).
  • Inflammation: Body's local response to injury or infection (symptoms: redness, heat, swelling, pain). Systemic response also involves an increase in neutrophils, fever, and shock. Pyrogens stimulate fever production.
  • Adaptive Immunity: Specialized response in fighting pathogens. 2 main characteristics—specificity and memory.
    • Specificity: Ability to recognize and respond to specific substances.
    • Memory: Responds with increasing effectiveness to subsequent exposure.
    • Antigens: Substances that stimulate adaptive immune responses. Foreign and self-antigens are possible.
    • Antibody-mediated immunity: Antibody production.
    • Cell-mediated immunity: T-cell activity (examples: cytotoxic T cells, helper T cells).
  • Natural and Artificial Immunity: Ways adaptive immunity is achieved through exposure (natural exposure) or through deliberate exposure—vaccination (artificial exposure). Natural exposure is not deliberate while artificial is deliberate.
  • Passive Immunity: Transferring immunity from an immune individual to a non-immune individual (examples include transfer of maternal antibodies, antiserum—antibodies from another individual).
  • Immunotherapy: Treating disease by altering immune system function or attacking harmful cells. Some approaches aim to boost immune system function.

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