30 Questions
Where do stimulated lymphocytes travel to through efferent lymphatic vessels?
Regional lymph nodes
What is the primary function of the thymus?
Maturation of T-cells
Where do effector cells enter after proliferation in regional lymph nodes?
General circulation
What term is used to describe lymphoid tissues that are well organized and encapsulated?
Lymphoid organ
Where do immature and maturing T-cells reside in the thymus?
Cortex
What is unique about the thymus compared to secondary lymphoid organs?
It lacks nodules and afferent lymphatic vessels
What is the location of the larger and more immature T-cells?
Outer cortex
What happens to T-cells that fail to mature properly?
They are removed by macrophages
What is the origin of the cells that form the structural framework of the thymic parenchyma?
Epithelial
What is the function of Hassall's corpuscles in the thymic medulla?
Their function is unknown
What is the site of negative selection in the thymus?
Medulla
What is the primary function of lymph nodes in the immune response?
To interact with antigens, antigen presenting cells, and lymphocytes
What happens to the thymus with advancing age?
It becomes smaller and is replaced by adipose tissue
What is the shape of lymph nodes?
Bean-shaped
What is the function of the cortical sinuses?
To connect the subcapsular sinus to the medullary sinuses
What is the region of the lymph node where lymphocytes are most concentrated?
Cortex
Through which vessels does lymph enter the lymph node?
Afferent lymphatic vessels
What is the region of the lymph node where the blood supply enters and leaves?
Hilum
What is the primary function of high endothelial venules in lymph nodes?
To allow lymphocytes to enter the lymph node from the blood
Where are B-lymphocytes typically localized in the lymph node cortex?
In lymphoid follicles just beneath the capsule
What is the name given to focal points of intense B-cell proliferation in lymphoid follicles during an immune response?
Germinal centers
What is the main cellular component of the medullary cords in the lymph node?
Macrophages and antibody-secreting plasma cells
What is the primary function of the reticular fibers in the lymph node?
To support the lymphocytes
Where is the spleen located in the body?
In the upper left quadrant of the abdomen
What is one of the functions of the spleen?
Disposal of senescent blood cells
What is the outermost layer of the spleen?
Capsule
What type of cells are found in the periarteriolar lymphoid sheath (PALS)?
T-cells
What is the function of the red pulp in the spleen?
Disposal of senescent erythrocytes
What is the name of the small white nodules embedded in the red pulp?
White nodules
What is the name of the region surrounding the follicle in the white pulp?
Mantle zone
Learn about the lymphatic system, lymphocyte maturation, and immune response. Understand how lymphocytes travel through lymph nodes and enter general circulation. Quiz yourself on primary and secondary lymphoid tissues.
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