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Questions and Answers
Where do B cells primarily collect in the lymph nodes?
Where do B cells primarily collect in the lymph nodes?
- Paracortical areas
- Outer cortex (correct)
- Medulla
- Germinal centres
What is the non-immunological role of the red pulp in the spleen?
What is the non-immunological role of the red pulp in the spleen?
- Contains plasma cells secreting Antibody
- Contains antigen presenting cells
- Filters damaged or aged red cells (correct)
- Develops immune responses
What structures in the spleen form the periarteriolar lymphatic sheath (PALS)?
What structures in the spleen form the periarteriolar lymphatic sheath (PALS)?
- Capsule
- Fibrous partitions (SEPTAE) (correct)
- Red pulp
- White pulp
Where do T cells primarily collect in the lymph nodes?
Where do T cells primarily collect in the lymph nodes?
During B cell development, immature B cells mature under local influences and are educated to not respond or bind to self molecules while arranging their B cell receptors. This process is an example of:
During B cell development, immature B cells mature under local influences and are educated to not respond or bind to self molecules while arranging their B cell receptors. This process is an example of:
What is the function of lymphatics in the lymphatic system?
What is the function of lymphatics in the lymphatic system?
Which molecules do lymphocytes bind to when using the lymphatics to migrate around the body?
Which molecules do lymphocytes bind to when using the lymphatics to migrate around the body?
What happens to immature B cells that do not leave the bone marrow during their maturation process?
What happens to immature B cells that do not leave the bone marrow during their maturation process?
What is the primary function of lymphocytes in the lymphatic system?
What is the primary function of lymphocytes in the lymphatic system?
Which type of vessels allow for the movement of cells from tissues to lymph nodes in the immune system?
Which type of vessels allow for the movement of cells from tissues to lymph nodes in the immune system?
What is the main purpose of high endothelial venules (HEV) in the context of lymph nodes?
What is the main purpose of high endothelial venules (HEV) in the context of lymph nodes?
What is the role of adhesion molecules (homing receptors) in the movement of leukocytes through the body?
What is the role of adhesion molecules (homing receptors) in the movement of leukocytes through the body?
What is the function of efferent vessels in the lymphatic system?
What is the function of efferent vessels in the lymphatic system?
Which type of cells recirculate between tissues, primary and secondary lymphoid organs via the blood and a network of vessels called the lymphatics?
Which type of cells recirculate between tissues, primary and secondary lymphoid organs via the blood and a network of vessels called the lymphatics?
T cells primarily collect in the outer cortex of the lymph nodes.
T cells primarily collect in the outer cortex of the lymph nodes.
The medulla of the lymph nodes contains T cells and antigen-presenting cells.
The medulla of the lymph nodes contains T cells and antigen-presenting cells.
Secondary follicles in the lymph nodes contain smaller cells associated with macrophages forming germinal centers.
Secondary follicles in the lymph nodes contain smaller cells associated with macrophages forming germinal centers.
Lymph nodes show decreased turnover of lymphocytes after antigen exposure.
Lymph nodes show decreased turnover of lymphocytes after antigen exposure.
The thymus is the first organ to produce lymphocytes and provides an environment for B cell maturation and education.
The thymus is the first organ to produce lymphocytes and provides an environment for B cell maturation and education.
The thymic nurse cells affect thymocyte development in the medulla of the thymus.
The thymic nurse cells affect thymocyte development in the medulla of the thymus.
Only 50% of original thymocytes make it through the thymus into circulation as naïve T cells.
Only 50% of original thymocytes make it through the thymus into circulation as naïve T cells.
Lymph nodes are surrounded by a reticulum and have three main areas: cortex, paracortical area, and medulla.
Lymph nodes are surrounded by a reticulum and have three main areas: cortex, paracortical area, and medulla.
The function of efferent vessels in the lymphatic system is to allow cells of the immune system to get together with antigen to start specific immune responses.
The function of efferent vessels in the lymphatic system is to allow cells of the immune system to get together with antigen to start specific immune responses.
High Endothelial Venules (HEV) in lymph nodes are responsible for the entry of lymphocytes and antigen into the lymph nodes.
High Endothelial Venules (HEV) in lymph nodes are responsible for the entry of lymphocytes and antigen into the lymph nodes.
The primary function of lymphocytes in the lymphatic system is to prevent backflow through lymphatics using adhesion molecules.
The primary function of lymphocytes in the lymphatic system is to prevent backflow through lymphatics using adhesion molecules.
The traffic of cells through the body to specific areas, such as lymph nodes, is called random movement.
The traffic of cells through the body to specific areas, such as lymph nodes, is called random movement.
Afferent lymphatic vessels carry antigens and cells from lymph nodes to tissues.
Afferent lymphatic vessels carry antigens and cells from lymph nodes to tissues.
Study Notes
- The lymphatic system facilitates movement of lymphocytes and other leukocytes between tissues and primary and secondary lymphoid organs
- Lymphocytes move through the body using a network of vessels called lymphatics, which are in close association with blood vessels
- Smooth muscle cell movement and backflow prevention valves regulate the flow of lymph in lymphatics
- Lymphocyte homing (migration) occurs via binding of adhesion molecules on lymphocytes to those on endothelial cells lining blood vessels
- Lymph nodes are small, bean-shaped tissues at junctions of major lymphatic vessels, surrounded by a capsule, and have three main areas: cortex, paracortical area, and medulla
- Afferent lymphatics carry antigen and cells from tissues to lymph nodes, and efferent lymphatics drain back into the blood circulatory system via the thoracic duct
- High endothelial venules (HEV) in lymph nodes allow lymphocytes and antigen to enter the lymph nodes
- Secondary lymphoid follicles in lymph nodes contain germinal centers with lots of cell proliferation
- The spleen is a secondary lymphoid organ with both non-immunological and immunological functions
- The spleen filters damaged or aged red cells, and lymphocytes enter and leave mainly via the blood stream
- Periarteriolar lymphatic sheaths and associated clusters of lymphocytes form lymphatic follicles or nodules in the spleen.
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Description
Explore the regulation of cell movement in the lymphatic system and its association with arterial pressure, smooth muscle cell movement, backflow prevention valves, and lymphocyte homing. Understand the non-random movement of leukocytes and their adhesion molecules.
