21 Questions
What is the typical age range for patients with Nodular Lymphocyte Predominant Hodgkin Lymphoma?
Median mid 30s (with a wide age range)
What is the typical immunophenotype of LP cells in Nodular Lymphocyte Predominant Hodgkin Lymphoma?
CD45+, CD19, CD20, CD22, CD79a+, PAX5+, CD15-, CD30-, EMA+
What is the characteristic appearance of LP cells in Nodular Lymphocyte Predominant Hodgkin Lymphoma?
Large cells with multilobated vesicular nuclei, delicate chromatin, small nucleoli, and scant wispy cytoplasm
What is the characteristic pattern of involvement in Classic Hodgkin Lymphoma, Nodular Sclerosis?
Nodular pattern with fibrous band separating nodules, +/- diffuse areas, +/- necrosis
What is the prognosis for patients with Classic Hodgkin Lymphoma, Nodular Sclerosis, presenting at stage I and II?
95% of patients are curable
What is the typical composition of the background cells in Nodular Lymphocyte Predominant Hodgkin Lymphoma?
Small B cells with normal mantle zone phenotype, accompanied by histiocytes, and rare plasma cells, eosinophils, or neutrophils
What are the characteristic microscopic features of Toxoplasmosis?
Florid follicular hyperplasia, Monocytoid B-cell hyperplasia expanding and surrounding sinuses, and Paracortical epithelioid histiocyte clusters that encroach on germinal centers.
What is the primary difference between Cytomegalovirus and Toxoplasmosis in terms of microscopic features?
CMV inclusions may sometimes be identified in the expanded sinuses.
What is the differential diagnosis of follicular lymphoma?
Dendritic cell sarcoma, Monocytoid B-cell hyperplasia, Epithelioid histiocyte clusters, and Increased plasma cells and polykaryocytes in interfollicular zones.
What is the characteristic feature of reactive follicular hyperplasia in Rheumatoid Arthritis?
Marked interfollicular plasmacytosis (plasma cells also present within follicles) and Clusters of neutrophils in sinuses.
What are the characteristic features of Castleman Disease: Plasma Cell Variant?
Florid follicular hyperplasia with regressive transformation of germinal centers and Marked interfollicular plasmacytosis that extends to the lymph node capsule.
What are the characteristic microscopic features of Human Immunodeficiency Virus (HIV)?
Florid reactive lymphoid hyperplasia with absent mantle zones and follicle lysis of germinal centers.
What is the primary cause of Toxoplasmosis?
Exposure to oocysts in cat feces or ingestion of poorly cooked meat.
What is the characteristic feature of Syphilis (Luetic Lymphadenitis)?
Thick, fibrotic capsule with perivascular plasma cells and arteritis/phlebitis.
What is the primary difference between Castleman Disease: Hyaline Vascular Type and Castleman Disease: Plasma Cell Variant?
Atrophic germinal centers with expanded mantle zones composed of concentric layers of lymphocytes in Castleman Disease: Hyaline Vascular Type.
What is the characteristic feature of Progressive Transformation of Germinal Centers?
Large follicles with indistinct germinal center/mantle zone borders due to infiltration of germinal centers by mantle zone lymphocytes.
What is the characteristic feature of paracortical expansion in infectious mononucleosis?
Paracortical expansion with EBV+ B cells located in the paracortex
What is the distinguishing feature of atypical immunoblastic reaction?
Similar microscopic features to infectious mononucleosis
How is the diagnosis of infectious mononucleosis confirmed?
By serologic studies and confirming EBV+ immunoblasts by in situ hybridization (EBER) or immunohistochemistry (LMP)
What type of cells are often seen in the sinuses in infectious mononucleosis?
Atypical lymphocytes, monocytoid B cells, and/or immunoblasts
What is the characteristic cytology of infectious mononucleosis?
Polymorphous population of transformed lymphocytes, immunoblasts, RS-like cells, plasma cells, and histiocytes
This quiz covers various types of histiocytic lymph node tumors and disorders, including sarcomas, hyperplasias, and other conditions affecting the lymph nodes. It also includes spindle cell lesions and follicular hyperplasias. Test your knowledge of these complex medical topics.
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