Lymph Node Tumors and Disorders

Median mid 30s (with a wide age range)

CD45+, CD19, CD20, CD22, CD79a+, PAX5+, CD15-, CD30-, EMA+

Large cells with multilobated vesicular nuclei, delicate chromatin, small nucleoli, and scant wispy cytoplasm

<p>Nodular pattern with fibrous band separating nodules, +/- diffuse areas, +/- necrosis</p> Signup and view all the answers

<p>95% of patients are curable</p> Signup and view all the answers

<p>Small B cells with normal mantle zone phenotype, accompanied by histiocytes, and rare plasma cells, eosinophils, or neutrophils</p> Signup and view all the answers

<p>Florid follicular hyperplasia, Monocytoid B-cell hyperplasia expanding and surrounding sinuses, and Paracortical epithelioid histiocyte clusters that encroach on germinal centers.</p> Signup and view all the answers

<p>CMV inclusions may sometimes be identified in the expanded sinuses.</p> Signup and view all the answers

<p>Dendritic cell sarcoma, Monocytoid B-cell hyperplasia, Epithelioid histiocyte clusters, and Increased plasma cells and polykaryocytes in interfollicular zones.</p> Signup and view all the answers

<p>Marked interfollicular plasmacytosis (plasma cells also present within follicles) and Clusters of neutrophils in sinuses.</p> Signup and view all the answers

<p>Florid follicular hyperplasia with regressive transformation of germinal centers and Marked interfollicular plasmacytosis that extends to the lymph node capsule.</p> Signup and view all the answers

<p>Florid reactive lymphoid hyperplasia with absent mantle zones and follicle lysis of germinal centers.</p> Signup and view all the answers

<p>Exposure to oocysts in cat feces or ingestion of poorly cooked meat.</p> Signup and view all the answers

<p>Thick, fibrotic capsule with perivascular plasma cells and arteritis/phlebitis.</p> Signup and view all the answers

<p>Atrophic germinal centers with expanded mantle zones composed of concentric layers of lymphocytes in Castleman Disease: Hyaline Vascular Type.</p> Signup and view all the answers

<p>Large follicles with indistinct germinal center/mantle zone borders due to infiltration of germinal centers by mantle zone lymphocytes.</p> Signup and view all the answers

<p>Paracortical expansion with EBV+ B cells located in the paracortex</p> Signup and view all the answers

<p>Similar microscopic features to infectious mononucleosis</p> Signup and view all the answers

<p>By serologic studies and confirming EBV+ immunoblasts by in situ hybridization (EBER) or immunohistochemistry (LMP)</p> Signup and view all the answers

<p>Atypical lymphocytes, monocytoid B cells, and/or immunoblasts</p> Signup and view all the answers

<p>Polymorphous population of transformed lymphocytes, immunoblasts, RS-like cells, plasma cells, and histiocytes</p> Signup and view all the answers