Lymph Node Response to Microbial Antigens
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Questions and Answers

What is the principal inducer of T-dependent responses in the immune system?

  • Macrophages
  • B cells
  • Dendritic cells (correct)
  • Natural killer cells
  • Which cell type expresses high levels of MHC molecules and costimulators, making it the most potent APC for activating naive T lymphocytes?

  • Dendritic cells (correct)
  • B cells
  • Natural killer cells
  • Macrophages
  • What type of cell accumulates at sites of infection in innate immune responses and is important for effector T cells, especially of the helper T cell lineage?

  • B cells
  • Macrophages (correct)
  • Dendritic cells
  • Natural killer cells
  • What type of cells are capable of migrating to lymph nodes, where they encounter naive T cells poised to recognize antigens?

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    Study Notes

    Antigen-Presenting Cells (APCs)

    • Dendritic cells are the principal inducer of T-dependent responses in the immune system.
    • Dendritic cells express high levels of MHC molecules and costimulators, making them the most potent APC for activating naive T lymphocytes.

    Innate Immune Response

    • Neutrophils accumulate at sites of infection in innate immune responses and are important for effector T cells, especially of the helper T cell lineage.

    Antigen Presentation

    • Dendritic cells are capable of migrating to lymph nodes, where they encounter naive T cells poised to recognize antigens.

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    Description

    Explore the process of how protein antigens of microbes are transported and concentrated in the regions of the lymph nodes, where they are likely to encounter T lymphocytes. Understand the role of dendritic cells and naive T cells in this process.

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