Lymph Node Response to Microbial Antigens

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4 Questions

What is the principal inducer of T-dependent responses in the immune system?

Dendritic cells

Which cell type expresses high levels of MHC molecules and costimulators, making it the most potent APC for activating naive T lymphocytes?

Dendritic cells

What type of cell accumulates at sites of infection in innate immune responses and is important for effector T cells, especially of the helper T cell lineage?

Macrophages

What type of cells are capable of migrating to lymph nodes, where they encounter naive T cells poised to recognize antigens?

Dendritic cells

Study Notes

Antigen-Presenting Cells (APCs)

  • Dendritic cells are the principal inducer of T-dependent responses in the immune system.
  • Dendritic cells express high levels of MHC molecules and costimulators, making them the most potent APC for activating naive T lymphocytes.

Innate Immune Response

  • Neutrophils accumulate at sites of infection in innate immune responses and are important for effector T cells, especially of the helper T cell lineage.

Antigen Presentation

  • Dendritic cells are capable of migrating to lymph nodes, where they encounter naive T cells poised to recognize antigens.

Explore the process of how protein antigens of microbes are transported and concentrated in the regions of the lymph nodes, where they are likely to encounter T lymphocytes. Understand the role of dendritic cells and naive T cells in this process.

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