Lymph Node Biology and Immune System

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Questions and Answers

What is the main function of Th1 subset of CD4+ T-cells?

  • Regulate the immune response
  • Eliminate extracellular microbes
  • Produce antibodies against pathogens
  • Combat intracellular microbes (correct)

What is the effect of cytokines produced by APCs on macrophages?

  • Suppress the immune response
  • Activate macrophages to eliminate intracellular microbes (correct)
  • Inhibit the activation of macrophages
  • Enhance the production of antibodies

What is the primary function of macrophages in the immune response?

  • Combat intracellular microbes (correct)
  • Regulate the immune response
  • Present antigens to T-cells
  • Eliminate extracellular microbes

What is the primary role of follicular helper T-cells?

<p>Produce antibodies against pathogens (B)</p> Signup and view all the answers

What is the role of ILC1 and ILC3 in the immune response?

<p>Provide immediate defense against infection (C)</p> Signup and view all the answers

What is the effect of TNF-α on the immune response?

<p>Induce inflammation and tissue damage (D)</p> Signup and view all the answers

What is the role of S1P receptors in T-cell activation?

<p>Regulating T-cell migration (A)</p> Signup and view all the answers

What is the outcome of T-cell activation in lymph nodes?

<p>Clonal expansion (D)</p> Signup and view all the answers

What is the function of high endothelial venules in lymph nodes?

<p>T-cell migration (D)</p> Signup and view all the answers

Which molecule is responsible for the egression of T-cells from lymph nodes?

<p>S1P (A)</p> Signup and view all the answers

What is the consequence of blocking S1P receptors in T-cells?

<p>Reduced T-cell migration (C)</p> Signup and view all the answers

What is the potential outcome of dysregulated T-cell activation in autoimmune diseases?

<p>Uncontrolled T-cell proliferation (A)</p> Signup and view all the answers

Which type of T-cells is primarily involved in autoimmune responses?

<p>Th1 (A)</p> Signup and view all the answers

Which of the following cytokines is associated with Th2 responses?

<p>IL-4 (A)</p> Signup and view all the answers

What is the primary function of CD8+ cells?

<p>Cytotoxicity (D)</p> Signup and view all the answers

What is the primary mechanism of action of Th1 cells?

<p>Activation of macrophages (A)</p> Signup and view all the answers

Which of the following is a characteristic of Th2 responses?

<p>Production of IgE antibodies (B)</p> Signup and view all the answers

What is the primary function of antigen-presenting cells (APCs)?

<p>Antigen presentation (B)</p> Signup and view all the answers

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