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Lymph Node Biology and Immune System

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Questions and Answers

What is the main function of Th1 subset of CD4+ T-cells?

Regulate the immune response

Eliminate extracellular microbes

Produce antibodies against pathogens

Combat intracellular microbes (correct)

What is the effect of cytokines produced by APCs on macrophages?

Suppress the immune response

Activate macrophages to eliminate intracellular microbes (correct)

Inhibit the activation of macrophages

Enhance the production of antibodies

What is the primary function of macrophages in the immune response?

Combat intracellular microbes (correct)

Regulate the immune response

Present antigens to T-cells

Eliminate extracellular microbes

What is the primary role of follicular helper T-cells?

Produce antibodies against pathogens Signup and view all the answers

What is the role of ILC1 and ILC3 in the immune response?

Provide immediate defense against infection Signup and view all the answers

What is the effect of TNF-α on the immune response?

Induce inflammation and tissue damage Signup and view all the answers

What is the role of S1P receptors in T-cell activation?

Regulating T-cell migration Signup and view all the answers

What is the outcome of T-cell activation in lymph nodes?

Clonal expansion Signup and view all the answers

What is the function of high endothelial venules in lymph nodes?

T-cell migration Signup and view all the answers

Which molecule is responsible for the egression of T-cells from lymph nodes?

S1P Signup and view all the answers

What is the consequence of blocking S1P receptors in T-cells?

Reduced T-cell migration Signup and view all the answers

What is the potential outcome of dysregulated T-cell activation in autoimmune diseases?

Uncontrolled T-cell proliferation Signup and view all the answers

Which type of T-cells is primarily involved in autoimmune responses?

Th1 Signup and view all the answers

Which of the following cytokines is associated with Th2 responses?

IL-4 Signup and view all the answers

What is the primary function of CD8+ cells?

Cytotoxicity Signup and view all the answers

What is the primary mechanism of action of Th1 cells?

Activation of macrophages Signup and view all the answers

Which of the following is a characteristic of Th2 responses?

Production of IgE antibodies Signup and view all the answers

What is the primary function of antigen-presenting cells (APCs)?

Antigen presentation Signup and view all the answers