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What is primarily responsible for the release of mature and functional proteins in the viral life cycle?

  • Viral genome replication enzymes
  • Capsid proteins of the virus
  • Host cell ribosomes
  • Viral protease 3Cpro and its precursor 3CD (correct)
  • Which feature of the Coxsackie A virus structure contributes to its stability in acidic environments?

  • Single-stranded RNA genome
  • Polyadenylation at the 3’ end
  • Presence of a viral envelope
  • Icosahedral shape (correct)
  • What type of RNA is present in the Coxsackie A virus genome?

  • Positive-sense single-stranded RNA (correct)
  • Double-stranded RNA
  • Negative-sense single-stranded RNA
  • Circular RNA
  • What is the function of the IRES found in the 5’ untranslated region of the Coxsackie A virus?

    <p>To allow for cap-independent translation</p> Signup and view all the answers

    Which symptom is NOT typically associated with Coxsackie A virus infections?

    <p>Persistent cough</p> Signup and view all the answers

    What is the primary receptor for Coxsackie A virus?

    <p>ICAM-1</p> Signup and view all the answers

    Which mode of transmission is primarily associated with Coxsackie A virus?

    <p>Fecal-oral route</p> Signup and view all the answers

    What genome composition does Rhinovirus possess?

    <p>(+) ssRNA</p> Signup and view all the answers

    At what temperature does Rhinovirus replicate best?

    <p>33°C</p> Signup and view all the answers

    Which of the following viral proteins plays a key role in disrupting cellular gene expression for Rhinovirus?

    <p>Protease 2A</p> Signup and view all the answers

    Rhinovirus is most commonly known to cause which condition?

    <p>Common Cold</p> Signup and view all the answers

    What mechanism does Rhinovirus use to evade host immune defenses?

    <p>Enhancing viral receptor expression</p> Signup and view all the answers

    Which of the following characteristics does Rhinovirus NOT share with Enteroviruses?

    <p>Transmission via respiratory aerosols</p> Signup and view all the answers

    Which of the following viruses is NOT a zoonotic coronavirus?

    <p>HIV</p> Signup and view all the answers

    What is the primary method of transmission for coronaviruses?

    <p>Aerosols and large droplets</p> Signup and view all the answers

    Which genogroup do MERS and SARS belong to?

    <p>Beta</p> Signup and view all the answers

    During replication, which component is essential for forming double membrane vesicles in coronaviruses?

    <p>Non-structural proteins</p> Signup and view all the answers

    How do coronaviruses typically evade the innate immune response?

    <p>By infecting antigen-presenting cells</p> Signup and view all the answers

    What role do the viral proteases 3CLpro and PLpro play in coronaviruses?

    <p>Cleaving NF-ĸB essential modulator</p> Signup and view all the answers

    The replication of the viral genomic RNA in coronaviruses is characterized by which of the following?

    <p>Inherent error-proneness</p> Signup and view all the answers

    What is formed during the transcription and replication of the coronavirus genome?

    <p>Replication membranes</p> Signup and view all the answers

    Which virulence factor associated with Streptococcus pyogenes significantly contributes to its ability to evade the immune system?

    <p>M protein</p> Signup and view all the answers

    What is the consequence of the hyaluronic acid capsule in Streptococcus pyogenes?

    <p>It protects against opsonization by complement.</p> Signup and view all the answers

    Which disease is NOT commonly associated with Streptococcus pyogenes?

    <p>Botulism</p> Signup and view all the answers

    Which of the following biochemical characteristics best identifies Streptococcus pyogenes?

    <p>Facultative anaerobic</p> Signup and view all the answers

    What role does C5a peptidase play in the pathogenicity of Streptococcus pyogenes?

    <p>Prevents recruitment of phagocytes to the infection site</p> Signup and view all the answers

    Which feature of the Streptococcus pyogenes enhances its ability to cause invasive infection?

    <p>Streptokinase activity</p> Signup and view all the answers

    Which of these Streptococcus pyogenes virulence factors is responsible for hemolysis of blood cells?

    <p>Streptolysin O</p> Signup and view all the answers

    What is the function of the F protein in Streptococcus pyogenes?

    <p>Binds to fibronectin in epithelial tissues</p> Signup and view all the answers

    What is the primary function of the replication organelle (RO) in viral infections?

    <p>To create a shelter for viral components</p> Signup and view all the answers

    What modification occurs at the 5' end of viral RNAs to evade host defenses?

    <p>2'-O methylation</p> Signup and view all the answers

    Which of the following statements accurately describes the role of IRF3 in antiviral signaling?

    <p>IRF3 can bind proteins that inhibit its activation</p> Signup and view all the answers

    How do coronaviruses (CoVs) counteract host RNA sensing mechanisms?

    <p>By destroying their own RNA at specific stages</p> Signup and view all the answers

    Which of the following microorganisms is commonly found in the mouth as part of the normal flora?

    <p>Streptococcus mutans</p> Signup and view all the answers

    Which group of bacteria is predominantly found in the oropharynx?

    <p>Gram-positive cocci</p> Signup and view all the answers

    In the mouth, how does the abundance of aerobes compare to that of anaerobes?

    <p>Anaerobes are significantly more abundant than aerobes</p> Signup and view all the answers

    What distinguishes the normal flora of the nasal cavity from that of the oropharynx?

    <p>Oropharynx has a higher prevalence of Streptococcus species</p> Signup and view all the answers

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