Losartan Pharmacology Quiz

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Questions and Answers

What is the mechanism of action of losartan?

  • Increases aldosterone secretion
  • Activates the AT1 receptor subtype in tissues
  • Stimulates the vasoconstrictor effects of angiotensin II
  • Blocks the binding of angiotensin II to the AT1 receptor subtype (correct)

What is a contraindication for losartan use?

  • Hypersensitivity to aliskiren
  • Concomitant use with aliskiren in diabetic patients (correct)
  • Renal function deterioration
  • Concomitant use with potassium supplements

Which drug interaction should be avoided when taking losartan?

  • Aliskiren and Lithium
  • Aliskiren and ACE inhibitors (correct)
  • Lithium and Angiotensin Receptor Blockers
  • Lithium and ACE inhibitors

What is a potential side effect of losartan?

<p>Upper respiratory infection and nasal congestion (C)</p> Signup and view all the answers

When should losartan be discontinued according to the black box warning?

<p>If pregnant (D)</p> Signup and view all the answers

What should patients avoid when taking losartan?

<p>Using potassium supplements without consulting a healthcare provider (C)</p> Signup and view all the answers

What risk is associated with abruptly withdrawing therapy in patients with hyperthyroidism?

<p>Precipitation of a thyroid storm (A)</p> Signup and view all the answers

Why should chronic beta blocker therapy not be routinely withdrawn in patients undergoing anesthesia and major surgery?

<p>To prevent impaired adrenergic response (C)</p> Signup and view all the answers

How does untreated pheochromocytoma influence the use of beta blockers?

<p>Should be avoided with pheochromocytoma (D)</p> Signup and view all the answers

In what condition should dose adjustment be considered due to renal impairment?

<p>Diabetes mellitus (B)</p> Signup and view all the answers

Why do patients with a history of severe anaphylactic reactions need caution during therapy?

<p>To prevent more severe reactions upon rechallenge (B)</p> Signup and view all the answers

In which condition should the use of drugs acting on the renin-angiotensin system be avoided due to the elevated risk of renal failure?

<p>Ascites due to cirrhosis (C)</p> Signup and view all the answers

What precaution should be taken when initiating drugs that act on the renin-angiotensin system in patients with heart failure?

<p>Monitor blood pressure carefully (B)</p> Signup and view all the answers

Which patient population should drugs acting on the renin-angiotensin system be used with caution in due to increased exposure to valsartan?

<p>Patients with hepatic impairment (D)</p> Signup and view all the answers

Why should careful monitoring of BUN, serum creatinine, and potassium be done in patients taking drugs that act on the renin-angiotensin system?

<p>To avoid renal failure (D)</p> Signup and view all the answers

When should the use of drugs acting on the renin-angiotensin system generally be avoided in patients with renal artery stenosis?

<p>Bilateral renal artery stenosis (C)</p> Signup and view all the answers

Why should drugs that act on the renin-angiotensin system be used with caution in patients with significant aortic/ mitral stenosis?

<p>Risk of hypotension (D)</p> Signup and view all the answers

What is the recommended initial dose of Tenormin for acute myocardial infarction?

<p>5 mg IV (B)</p> Signup and view all the answers

For how long should Tenormin be administered in patients with acute myocardial infarction after the IV dosing?

<p>6 to 9 days (B)</p> Signup and view all the answers

What is the guideline dosage range for Tenormin in hypertension?

<p>25 to 100 mg orally daily (A)</p> Signup and view all the answers

Which statement accurately describes the mechanism of action of Atenolol?

<p>Primarily acts on beta (2)-adrenoreceptors (B)</p> Signup and view all the answers

What is the recommended initial dose of Tenormin for angina pectoris, chronic?

<p>100 mg ORALLY once daily (C)</p> Signup and view all the answers

What should be done if angina worsens or acute coronary insufficiency occurs in a patient receiving Tenormin for angina pectoris?

<p>Gradually stop therapy and reinstitute if needed (D)</p> Signup and view all the answers

Which of the following is a common side effect of Valsartan?

<p>Backache (B)</p> Signup and view all the answers

What is the initial dosage for treating Post–myocardial infarction with Valsartan?

<p>20 mg twice daily (A)</p> Signup and view all the answers

Which of the following is NOT a dosage form of Valsartan?

<p>Tablet, Oral: 50 mg (D)</p> Signup and view all the answers

Which of the following is NOT a contraindication or precaution for Valsartan?

<p>Avoid use in patients with liver disease (A)</p> Signup and view all the answers

Which of the following is the mechanism of action of Valsartan?

<p>Antagonism of the angiotensin II (AT2) receptors (A)</p> Signup and view all the answers

Which of the following is the brand name for Valsartan?

<p>Diovan (B)</p> Signup and view all the answers

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