Podcast
Questions and Answers
What happens when the concentration of local anesthetic (LA) reaches a significant level in the body?
What happens when the concentration of local anesthetic (LA) reaches a significant level in the body?
- It affects organs dependent on sodium channel conduction. (correct)
- It causes immediate relief of pain.
- It results in rapid metabolism of the drug.
- It leads to a concentration in the muscle tissue.
Which factor does NOT influence the rate of absorption of local anesthetics into the systemic circulation?
Which factor does NOT influence the rate of absorption of local anesthetics into the systemic circulation?
- Presence of soluble salts in the anesthetic.
- Type of organ affected by sodium channels. (correct)
- Vascularity of the injection site.
- Amount of local anesthetic given.
What is a potential consequence of high binding capacity of local anesthetics like bupivacaine?
What is a potential consequence of high binding capacity of local anesthetics like bupivacaine?
- Faster onset of pain relief.
- Decrease in metabolism speed.
- Increased duration of action and risk of toxicity. (correct)
- Diminished effectiveness due to dilution.
What is the most likely cause of life-threatening symptoms after plasma saturation with local anesthetics?
What is the most likely cause of life-threatening symptoms after plasma saturation with local anesthetics?
How does enzyme dysfunction in plasma affect local anesthetic metabolism?
How does enzyme dysfunction in plasma affect local anesthetic metabolism?
Which component of blood primarily carries local anesthetics in the plasma?
Which component of blood primarily carries local anesthetics in the plasma?
Which tissue is most likely to be affected by systemic local anesthetic toxicity due to high blood perfusion?
Which tissue is most likely to be affected by systemic local anesthetic toxicity due to high blood perfusion?
What percentage of plasma is composed of water?
What percentage of plasma is composed of water?
Flashcards
Systemic Toxicity
Systemic Toxicity
LA absorption into the bloodstream causing adverse effects on tissues dependent on sodium channel function, mainly heart and CNS.
Toxic Level
Toxic Level
The concentration of LA that causes adverse effects on organ function.
Absorption Rate
Absorption Rate
The rate at which LA enters the bloodstream.
LA Dosage & Vascularity
LA Dosage & Vascularity
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Plasma & LA Binding
Plasma & LA Binding
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Plasma Saturation
Plasma Saturation
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LA Metabolism
LA Metabolism
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Plasma Enzymes & LA Metabolism
Plasma Enzymes & LA Metabolism
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