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Local Anesthetics Quiz

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Questions and Answers

What happens when the concentration of local anesthetic (LA) reaches a significant level in the body?

It affects organs dependent on sodium channel conduction. (correct)
It causes immediate relief of pain.
It results in rapid metabolism of the drug.
It leads to a concentration in the muscle tissue.

Which factor does NOT influence the rate of absorption of local anesthetics into the systemic circulation?

Presence of soluble salts in the anesthetic.
Type of organ affected by sodium channels. (correct)
Vascularity of the injection site.
Amount of local anesthetic given.

What is a potential consequence of high binding capacity of local anesthetics like bupivacaine?

Faster onset of pain relief.
Decrease in metabolism speed.
Increased duration of action and risk of toxicity. (correct)
Diminished effectiveness due to dilution.

What is the most likely cause of life-threatening symptoms after plasma saturation with local anesthetics?

Increase in the level of free drug in circulation. (B) Signup and view all the answers

How does enzyme dysfunction in plasma affect local anesthetic metabolism?

It can reduce the metabolism of local anesthetics. (A) Signup and view all the answers

Which component of blood primarily carries local anesthetics in the plasma?

Water and other solutes. (A) Signup and view all the answers

Which tissue is most likely to be affected by systemic local anesthetic toxicity due to high blood perfusion?

Cardiac muscle. (A) Signup and view all the answers

What percentage of plasma is composed of water?

91% (D) Signup and view all the answers

Flashcards

Systemic Toxicity

LA absorption into the bloodstream causing adverse effects on tissues dependent on sodium channel function, mainly heart and CNS.

Toxic Level

The concentration of LA that causes adverse effects on organ function.

Absorption Rate

The rate at which LA enters the bloodstream.

LA Dosage & Vascularity

Influence of LA on the body depends on how much LA is given and how easily it can spread.

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Plasma & LA Binding

Plasma is the watery portion of blood where LA molecules dissolve.

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Plasma Saturation

The phenomenon where increasing concentrations of LA in the bloodstream rapidly lead to toxicity.