Local Anesthetics Quiz

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Questions and Answers

Local Anesthetics interrupt pain impulses in a specific region of the body without a loss of consciousness

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Local Infiltration is a type of local anesthesia that involves direct injection into tissues to reach nerve branches

Local Anesthesia

The two main classes of local anesthetics are ester linked and amide linked

The ideal properties of local anesthetics include low systemic toxicity, quick onset of action, and duration of action sufficient for the surgical procedure

Soluble in water and stable in solution Signup and view all the answers

Surface Anesthetics: – – Soluble agents:

Cocaine, Lignocaine Signup and view all the answers

Differences between Ester LAs and Amide LAs Ester LAs Amide L As short duration

longer duration Signup and view all the answers

Hypersensitivity:

high Signup and view all the answers

Mechanism of Action LAs block action potential generation by blocking sodium channels. LAs interact with a receptor situated within the voltage sensitive Na channel and raise threshold of channel opening:

– Na permeability fails to increase in response to an impulse or stimulus. Signup and view all the answers

Frequency – dependant block Also called:

– use dependence block Signup and view all the answers

Depth of block increases with action potential frequency Order of sensory function block 1. 2. 3. 4. 5. 6.

Pain Cold Warmth Touch Deep Pressure Motor Signup and view all the answers

Main unwanted effects CNS effects:

– Agitation, confusion, tremors, convulsions and respiratory depression Signup and view all the answers

Vasoconstrictors:

– decrease the rate of vascular absorption – more anesthetic reaches the nerve membrane – improves the depth of anesthesia – increases duration of action – decreases systemic toxicity 1:200,000 epinephrine appears to be the best vasoconstrictor Signup and view all the answers

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