Liver Regeneration and Healing

What is the term for the process by which the liver grows back its missing part after liver necrosis?

What happens when cells on the border of the deleted cells in the liver cannot divide?

What type of cells are responsible for laying down collagen and scar tissue during the healing process?

What is the outcome of fibrosis in terms of organ function?

What is the process that occurs when the finger is sliced during cooking and blood is coming out?

What type of cells do not divide?

Within 24 hours of tissue damage, what cells start coming to the area?

What is the outcome of primary union wound healing?

What type of wound healing is characterized by scanty granulation tissue?

What is the main characteristic of permanent cells?

What type of cells are capable of regeneration when confronted with an appropriate stimulus?

What is the characteristic of wound healing by connective tissue repair?

What is the outcome of secondary union wound healing?

Liver Regeneration

Liver cells (hepatocytes) can be deleted due to various reasons, leading to liver necrosis and loss of liver tissue
Bordering cells can initiate a cascade of tissue repair through regeneration, where they divide and try to regrow the organ's architecture
If cells cannot divide, healing and fibrosis occur, resulting in loss of function but maintenance of organ architecture

Injury Repair

In the case of a sliced finger, tissues cut through include fingernail, epithelial skin, muscle tissue, and nerve endings
Nerve cells do not divide, while skin cells divide rapidly
Within 24 hours, inflammation and repair processes begin, with leukocytes and fibroblasts coming to the area to lay down collagen and scar tissue
By 3-5 days, a new scar tissue forms to fill in the place of nerve and new skin tissue, known as granulation tissue

Cell Types and Proliferation

Labile cells: able to proliferate
Stable cells: minimally proliferative
Permanent cells: terminally differentiated and non-proliferative in postnatal life
Cells replaced by mature stem cells and proliferation allow for regeneration
Regeneration capacity is limited in some cells

Healing by Connective Tissue Repair

Unable to regenerate, repair is dominated by scar formation
Insufficient to reproduce tissue regeneration after injury

Wound Healing

Primary union (1st intention): clean, surgically clean, sutures used, and healing results in a neat linear scar
Secondary union (2nd intention): may be infected, sutures not used, healing results in exuberant granulation tissue to fill the gap
Cleanliness and infection affect the healing process
Complications include contracted irregular scar, epidermal inclusion cyst formation, suppuration, and may require debridement

Learn about the process of liver regeneration and healing after liver necrosis, including the role of hepatocytes and cell division. Understand how the cells on the border of the damaged area initiate tissue repair.