Questions and Answers
What is the term for the process by which the liver grows back its missing part after liver necrosis?
What happens when cells on the border of the deleted cells in the liver cannot divide?
What type of cells are responsible for laying down collagen and scar tissue during the healing process?
What is the outcome of fibrosis in terms of organ function?
Signup and view all the answers
What is the process that occurs when the finger is sliced during cooking and blood is coming out?
Signup and view all the answers
What type of cells do not divide?
Signup and view all the answers
Within 24 hours of tissue damage, what cells start coming to the area?
Signup and view all the answers
What is the outcome of primary union wound healing?
Signup and view all the answers
What type of wound healing is characterized by scanty granulation tissue?
Signup and view all the answers
What is the main characteristic of permanent cells?
Signup and view all the answers
What type of cells are capable of regeneration when confronted with an appropriate stimulus?
Signup and view all the answers
What is the characteristic of wound healing by connective tissue repair?
Signup and view all the answers
What is the outcome of secondary union wound healing?
Signup and view all the answers
Study Notes
Liver Regeneration
- Liver cells (hepatocytes) can be deleted due to various reasons, leading to liver necrosis and loss of liver tissue
- Bordering cells can initiate a cascade of tissue repair through regeneration, where they divide and try to regrow the organ's architecture
- If cells cannot divide, healing and fibrosis occur, resulting in loss of function but maintenance of organ architecture
Injury Repair
- In the case of a sliced finger, tissues cut through include fingernail, epithelial skin, muscle tissue, and nerve endings
- Nerve cells do not divide, while skin cells divide rapidly
- Within 24 hours, inflammation and repair processes begin, with leukocytes and fibroblasts coming to the area to lay down collagen and scar tissue
- By 3-5 days, a new scar tissue forms to fill in the place of nerve and new skin tissue, known as granulation tissue
Cell Types and Proliferation
- Labile cells: able to proliferate
- Stable cells: minimally proliferative
- Permanent cells: terminally differentiated and non-proliferative in postnatal life
- Cells replaced by mature stem cells and proliferation allow for regeneration
- Regeneration capacity is limited in some cells
Healing by Connective Tissue Repair
- Unable to regenerate, repair is dominated by scar formation
- Insufficient to reproduce tissue regeneration after injury
Wound Healing
- Primary union (1st intention): clean, surgically clean, sutures used, and healing results in a neat linear scar
- Secondary union (2nd intention): may be infected, sutures not used, healing results in exuberant granulation tissue to fill the gap
- Cleanliness and infection affect the healing process
- Complications include contracted irregular scar, epidermal inclusion cyst formation, suppuration, and may require debridement
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Learn about the process of liver regeneration and healing after liver necrosis, including the role of hepatocytes and cell division. Understand how the cells on the border of the damaged area initiate tissue repair.
