Liver Pathology: Fibrosis and Necrosis Quiz
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Questions and Answers

Where does periportal fibrosis primarily occur?

  • Around the central vein
  • Around the sinusoids
  • Around the portal vein (correct)
  • In the hepatic lobule

What type of cells does the cell of the canal of Hering serve as a progenitor for?

  • Hepatocytes & bile duct cells (correct)
  • Endothelial cells & macrophages
  • Red blood cells & white blood cells
  • Kupffer cells & stellate cells

In which type of cirrhosis is the liver characterized by small nodules?

  • Mixed nodular cirrhosis
  • Macronodular cirrhosis (correct)
  • Microvesicular cirrhosis
  • Panlobular cirrhosis

What is the result of hepatic failure?

<p>Loss of 80-90% of hepatic functional capacity (A)</p> Signup and view all the answers

What proliferates around the central area near the central vein in hepatic pathology?

<p>Ductular cells (D)</p> Signup and view all the answers

What may accumulate in viable hepatocytes in the presence of hepatic dysfunction?

<p>Fat (A)</p> Signup and view all the answers

Which material is likely to be retained in viable hepatocytes due to hepatic dysfunction?

<p>Wilson disease (D)</p> Signup and view all the answers

What can cause irregularly clumped cytoplasm with clear spaces in hepatocytes?

<p>Reye's syndrome (B)</p> Signup and view all the answers

Which of the following is associated with hepatic dysfunction and irregularly clumped cytoplasm in hepatocytes?

<p>Tetracycline toxicity (C)</p> Signup and view all the answers

What substance can lead to large clear spaces within the cytoplasm of hepatocytes?

<p>Estrogen (B)</p> Signup and view all the answers

What is the primary function of the hepatic artery in the text?

<p>Transporting nutrients to the liver (C)</p> Signup and view all the answers

What is the role of bridging necrosis as described in the text?

<p>Linking portal and hepatic veins in liver pathology (B)</p> Signup and view all the answers

What is a characteristic of Fibrosis in the context provided?

<p>Progressive scarring of liver tissue (D)</p> Signup and view all the answers

What is the impact of Necrosis on liver parenchyma?

<p>Leads to disorganized arrangement of hepatocytes (C)</p> Signup and view all the answers

What defines Hepatocytes based on the information provided?

<p>Main structural cells of the liver responsible for various functions (C)</p> Signup and view all the answers

What is the major source of collagen in cirrhosis?

<p>Perisinusoidal stellate cells (D)</p> Signup and view all the answers

Which cells in the liver act as storage cells for vitamin A and fat?

<p>Perisinusoidal stellate cells (C)</p> Signup and view all the answers

What substances are deposited in the space of Disse in cirrhosis?

<p>Type I &amp; III collagen along with other substances (D)</p> Signup and view all the answers

What is the primary function of perisinusoidal stellate cells in a healthy liver?

<p>Store vitamin A &amp; fat (A)</p> Signup and view all the answers

In cirrhosis, where do perisinusoidal stellate cells deposit collagen?

<p>Space of Disse (D)</p> Signup and view all the answers

What is the primary cause of portal hypertension in the context provided?

<p>Increased resistance to portal blood flow (D)</p> Signup and view all the answers

Which complication is characterized by compression of central veins by perivenular fibrosis and parenchymal nodules?

<p>Portal hypertension (C)</p> Signup and view all the answers

How does the development of arterial-portal anastomosis contribute to portal hypertension?

<p>Increases resistance to portal blood flow (C)</p> Signup and view all the answers

What is one consequence of progressive hepatic failure?

<p>Development of hepatocellular carcinoma (D)</p> Signup and view all the answers

In the context provided, what role do fibrous bands play in the pathophysiology?

<p>Increase resistance to portal blood flow (D)</p> Signup and view all the answers

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