Liver Pathology: Fibrosis and Necrosis Quiz
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Questions and Answers

Where does periportal fibrosis primarily occur?

  • Around the central vein
  • Around the sinusoids
  • Around the portal vein (correct)
  • In the hepatic lobule
  • What type of cells does the cell of the canal of Hering serve as a progenitor for?

  • Hepatocytes & bile duct cells (correct)
  • Endothelial cells & macrophages
  • Red blood cells & white blood cells
  • Kupffer cells & stellate cells
  • In which type of cirrhosis is the liver characterized by small nodules?

  • Mixed nodular cirrhosis
  • Macronodular cirrhosis (correct)
  • Microvesicular cirrhosis
  • Panlobular cirrhosis
  • What is the result of hepatic failure?

    <p>Loss of 80-90% of hepatic functional capacity</p> Signup and view all the answers

    What proliferates around the central area near the central vein in hepatic pathology?

    <p>Ductular cells</p> Signup and view all the answers

    What may accumulate in viable hepatocytes in the presence of hepatic dysfunction?

    <p>Fat</p> Signup and view all the answers

    Which material is likely to be retained in viable hepatocytes due to hepatic dysfunction?

    <p>Wilson disease</p> Signup and view all the answers

    What can cause irregularly clumped cytoplasm with clear spaces in hepatocytes?

    <p>Reye's syndrome</p> Signup and view all the answers

    Which of the following is associated with hepatic dysfunction and irregularly clumped cytoplasm in hepatocytes?

    <p>Tetracycline toxicity</p> Signup and view all the answers

    What substance can lead to large clear spaces within the cytoplasm of hepatocytes?

    <p>Estrogen</p> Signup and view all the answers

    What is the primary function of the hepatic artery in the text?

    <p>Transporting nutrients to the liver</p> Signup and view all the answers

    What is the role of bridging necrosis as described in the text?

    <p>Linking portal and hepatic veins in liver pathology</p> Signup and view all the answers

    What is a characteristic of Fibrosis in the context provided?

    <p>Progressive scarring of liver tissue</p> Signup and view all the answers

    What is the impact of Necrosis on liver parenchyma?

    <p>Leads to disorganized arrangement of hepatocytes</p> Signup and view all the answers

    What defines Hepatocytes based on the information provided?

    <p>Main structural cells of the liver responsible for various functions</p> Signup and view all the answers

    What is the major source of collagen in cirrhosis?

    <p>Perisinusoidal stellate cells</p> Signup and view all the answers

    Which cells in the liver act as storage cells for vitamin A and fat?

    <p>Perisinusoidal stellate cells</p> Signup and view all the answers

    What substances are deposited in the space of Disse in cirrhosis?

    <p>Type I &amp; III collagen along with other substances</p> Signup and view all the answers

    What is the primary function of perisinusoidal stellate cells in a healthy liver?

    <p>Store vitamin A &amp; fat</p> Signup and view all the answers

    In cirrhosis, where do perisinusoidal stellate cells deposit collagen?

    <p>Space of Disse</p> Signup and view all the answers

    What is the primary cause of portal hypertension in the context provided?

    <p>Increased resistance to portal blood flow</p> Signup and view all the answers

    Which complication is characterized by compression of central veins by perivenular fibrosis and parenchymal nodules?

    <p>Portal hypertension</p> Signup and view all the answers

    How does the development of arterial-portal anastomosis contribute to portal hypertension?

    <p>Increases resistance to portal blood flow</p> Signup and view all the answers

    What is one consequence of progressive hepatic failure?

    <p>Development of hepatocellular carcinoma</p> Signup and view all the answers

    In the context provided, what role do fibrous bands play in the pathophysiology?

    <p>Increase resistance to portal blood flow</p> Signup and view all the answers

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