25 Questions
Where does periportal fibrosis primarily occur?
Around the portal vein
What type of cells does the cell of the canal of Hering serve as a progenitor for?
Hepatocytes & bile duct cells
In which type of cirrhosis is the liver characterized by small nodules?
Macronodular cirrhosis
What is the result of hepatic failure?
Loss of 80-90% of hepatic functional capacity
What proliferates around the central area near the central vein in hepatic pathology?
Ductular cells
What may accumulate in viable hepatocytes in the presence of hepatic dysfunction?
Fat
Which material is likely to be retained in viable hepatocytes due to hepatic dysfunction?
Wilson disease
What can cause irregularly clumped cytoplasm with clear spaces in hepatocytes?
Reye's syndrome
Which of the following is associated with hepatic dysfunction and irregularly clumped cytoplasm in hepatocytes?
Tetracycline toxicity
What substance can lead to large clear spaces within the cytoplasm of hepatocytes?
Estrogen
What is the primary function of the hepatic artery in the text?
Transporting nutrients to the liver
What is the role of bridging necrosis as described in the text?
Linking portal and hepatic veins in liver pathology
What is a characteristic of Fibrosis in the context provided?
Progressive scarring of liver tissue
What is the impact of Necrosis on liver parenchyma?
Leads to disorganized arrangement of hepatocytes
What defines Hepatocytes based on the information provided?
Main structural cells of the liver responsible for various functions
What is the major source of collagen in cirrhosis?
Perisinusoidal stellate cells
Which cells in the liver act as storage cells for vitamin A and fat?
Perisinusoidal stellate cells
What substances are deposited in the space of Disse in cirrhosis?
Type I & III collagen along with other substances
What is the primary function of perisinusoidal stellate cells in a healthy liver?
Store vitamin A & fat
In cirrhosis, where do perisinusoidal stellate cells deposit collagen?
Space of Disse
What is the primary cause of portal hypertension in the context provided?
Increased resistance to portal blood flow
Which complication is characterized by compression of central veins by perivenular fibrosis and parenchymal nodules?
Portal hypertension
How does the development of arterial-portal anastomosis contribute to portal hypertension?
Increases resistance to portal blood flow
What is one consequence of progressive hepatic failure?
Development of hepatocellular carcinoma
In the context provided, what role do fibrous bands play in the pathophysiology?
Increase resistance to portal blood flow
Test your knowledge on liver pathology focusing on fibrosis, necrosis, and bridging necrosis. Identify the structures involved in receiving and sending blood from the portal through the hepatic artery and vein.
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