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Explain the dual blood supply of the liver and the percentage of blood supply from the portal vein and hepatic artery.
Explain the dual blood supply of the liver and the percentage of blood supply from the portal vein and hepatic artery.
The liver receives dual blood supply, with 60-70% coming from the portal vein and 30-40% from the hepatic artery.
Describe the hexagonal lobular model of liver anatomy and the significance of zones in the acinar model based on blood flow.
Describe the hexagonal lobular model of liver anatomy and the significance of zones in the acinar model based on blood flow.
The hexagonal lobular model of liver anatomy outlines the hepatic artery, portal vein, and bile duct. The acinar model defines three zones based on blood flow, with varying sensitivities of hepatocytes due to differences in oxygenation and metabolic activities.
What are the reversible changes associated with liver injury, and what is Mallory hyaline?
What are the reversible changes associated with liver injury, and what is Mallory hyaline?
Reversible changes in liver injury include accumulations of fat (steatosis) and bilirubin (cholestasis), as well as ballooning, leading to Mallory hyaline.
Explain the mechanisms of liver injury and repair.
Explain the mechanisms of liver injury and repair.
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Discuss the laboratory evaluation of liver disease, including the parameters commonly assessed.
Discuss the laboratory evaluation of liver disease, including the parameters commonly assessed.
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