Podcast
Questions and Answers
What is the predominant function of hepatocytes in zone 1?
What is the predominant function of hepatocytes in zone 1?
- Bile salts synthesis
- Gluconeogenesis
- Fatty acid oxidation (correct)
- Ammonia detoxification to urea
Which zone of the acinus is considered hypoxic relative to other tissues?
Which zone of the acinus is considered hypoxic relative to other tissues?
- Zone 1
- Zone 3 (correct)
- Zone 2
- Zone 4
What is a notable gradient observed for hepatotoxins along the acinus?
What is a notable gradient observed for hepatotoxins along the acinus?
- Higher levels of bile salts in zone 1
- Greater amounts of glutathione in zone 3 (correct)
- Higher levels of ammonia in the hepatic vein
- Lower levels of cytochrome P450 proteins in the sinusoids
Which cells are NOT found in the hepatic sinusoids?
Which cells are NOT found in the hepatic sinusoids?
In comparison to other tissues, which zone of the acinus is exposed to substantially lower concentrations of oxygen?
In comparison to other tissues, which zone of the acinus is exposed to substantially lower concentrations of oxygen?
What is the inducible CYP2E1 isozyme primarily involved in?
What is the inducible CYP2E1 isozyme primarily involved in?
Which vessel carries oxygen-depleted blood from the portal vein?
Which vessel carries oxygen-depleted blood from the portal vein?
Which of the following is NOT a mechanism of toxin-induced injury to liver cells?
Which of the following is NOT a mechanism of toxin-induced injury to liver cells?
What is the biochemical characteristic of canalicular cholestasis?
What is the biochemical characteristic of canalicular cholestasis?
What is the biochemical index of bile duct damage?
What is the biochemical index of bile duct damage?
What condition can chronic administration of toxins that cause bile duct destruction lead to?
What condition can chronic administration of toxins that cause bile duct destruction lead to?
Which of the following can compromise the functional integrity of the sinusoid?
Which of the following can compromise the functional integrity of the sinusoid?
What is the result of cholestasis?
What is the result of cholestasis?
What is the definition of cholestasis?
What is the definition of cholestasis?
What type of cholestasis is characterized by damage to the intrahepatic bile ducts?
What type of cholestasis is characterized by damage to the intrahepatic bile ducts?
Which of the following is NOT a component of bile?
Which of the following is NOT a component of bile?
The inability to export copper into bile is a central problem in which genetic disorder?
The inability to export copper into bile is a central problem in which genetic disorder?
Which of the following metals is NOT mentioned in the text as being excreted into bile?
Which of the following metals is NOT mentioned in the text as being excreted into bile?
What is the primary function of bile formation in the liver?
What is the primary function of bile formation in the liver?
Which of the following processes is NOT involved in the excretion of metals into bile?
Which of the following processes is NOT involved in the excretion of metals into bile?
Which of the following statements about biliary excretion is true?
Which of the following statements about biliary excretion is true?
Which of the following is NOT a step in the formation of bile by hepatocytes?
Which of the following is NOT a step in the formation of bile by hepatocytes?
Which of the following statements about the components of bile is true?
Which of the following statements about the components of bile is true?
Which enzyme is responsible for the bioactivation of ethanol?
Which enzyme is responsible for the bioactivation of ethanol?
What is the consequence of having a slow aldehyde dehydrogenase polymorphism when consuming alcohol?
What is the consequence of having a slow aldehyde dehydrogenase polymorphism when consuming alcohol?
Which cytochrome P450 isozyme is implicated in the etiology of serious, end-stage liver damage?
Which cytochrome P450 isozyme is implicated in the etiology of serious, end-stage liver damage?
What is the mechanism by which acetaminophen can cause liver injury at high doses?
What is the mechanism by which acetaminophen can cause liver injury at high doses?
Which of the following treatments can minimize acetaminophen-induced hepatotoxicity?
Which of the following treatments can minimize acetaminophen-induced hepatotoxicity?
At therapeutic doses, what is the primary metabolic pathway for acetaminophen?
At therapeutic doses, what is the primary metabolic pathway for acetaminophen?
Which ethnic group is more likely to have the slow aldehyde dehydrogenase polymorphism?
Which ethnic group is more likely to have the slow aldehyde dehydrogenase polymorphism?
What is the mechanism by which cytochrome P450 isozymes can contribute to hepatotoxicity?
What is the mechanism by which cytochrome P450 isozymes can contribute to hepatotoxicity?
What is the primary cause of veno-occlusive disease?
What is the primary cause of veno-occlusive disease?
Which of the following statements about cirrhosis is true?
Which of the following statements about cirrhosis is true?
Which type of liver tumor is associated with exposure to thorium dioxide?
Which type of liver tumor is associated with exposure to thorium dioxide?
What is the primary role of phase I enzymes in hepatocytes?
What is the primary role of phase I enzymes in hepatocytes?
Which of the following statements about phase II enzymes in hepatocytes is true?
Which of the following statements about phase II enzymes in hepatocytes is true?
Which of the following is a potential risk factor for hepatocellular carcinoma?
Which of the following is a potential risk factor for hepatocellular carcinoma?
Which type of liver tumor is derived from sinusoidal lining cells?
Which type of liver tumor is derived from sinusoidal lining cells?
What is the primary function of bile formation in the liver?
What is the primary function of bile formation in the liver?
