Lithium in Bipolar Disorder Treatment

Exclusively by the kidneys

Because the difference between the minimum effective dose and the toxic dose is relatively small

They can acutely reduce glomerular filtration and clearance of lithium, potentially leading to drug toxicity

<p>They inhibit reabsorption of sodium in the distal convoluted tubule, causing a compensatory increase in reabsorption of lithium in the proximal tubule</p> Signup and view all the answers

<p>Some can raise lithium levels, while others can lower lithium levels, likely due to effects on both sodium transport and glomerular filtration</p> Signup and view all the answers

<p>They do not significantly affect sodium levels or glomerular filtration rate</p> Signup and view all the answers