Questions and Answers
What is Lisinopril commonly known as?
What is the therapeutic class of Lisinopril?
Drug for heart failure and HTN
What is the pharmacologic class of Lisinopril?
ACE inhibitor
What are the primary actions of Lisinopril?
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What should be assessed prior to administering Lisinopril?
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What are common adverse effects of Lisinopril?
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Lisinopril is safe to use during pregnancy.
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In which conditions is Lisinopril contraindicated?
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Which of the following can interact with Lisinopril?
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Study Notes
Lisinopril Overview
- Lisinopril is marketed under the names Prinivil and Zestril.
- It belongs to the therapeutic class of drugs used for heart failure (HF) and hypertension (HTN).
- Pharmacologically classified as an ACE inhibitor.
Actions and Uses
- Lisinopril is commonly prescribed for its effectiveness in treating HF and HTN.
- Inhibits angiotensin-converting enzyme (ACE), leading to decreased aldosterone secretion.
- Results in lower blood pressure and increased cardiac output.
- Maximum effectiveness may take 2 to 3 weeks, with several months required for cardiac function normalization.
- Can improve survival outcomes when administered within 24 hours of an acute myocardial infarction (MI).
- Fixed-dose combinations with hydrochlorothiazide are available for hypertension under the names Prinzide and Zestoretic.
- Off-label use includes treatment for migraines.
Administration Alerts
- Blood pressure should be assessed before administration to ensure stability for 24 hours.
- Safe for use in children aged 6 and older; older adults with chronic kidney disease may need reduced doses to avoid toxicity.
- Classified as pregnancy category C (first trimester) and D (second and third trimesters); discontinue if pregnancy is suspected.
Adverse Effects
- Generally well tolerated, with common side effects including cough, headache, dizziness, and rash.
- Risk of hyperkalemia requires periodic monitoring of electrolyte levels.
- Other effects may involve taste disturbances, chest pain, gastrointestinal symptoms (nausea, vomiting, diarrhea).
- Rarely, angioedema can occur, which is a serious adverse effect.
Black Box Warning
- Use during pregnancy can lead to fetal injury or death; should be discontinued immediately upon detection of pregnancy.
Contraindications
- Not suitable for patients with hyperkalemia or those who have had angioedema from previous ACE inhibitor therapy.
- Contraindicated for use during pregnancy.
Interactions
- Food: Excessive potassium intake can pose risks.
- Drug interactions: Nonsteroidal anti-inflammatory drugs (NSAIDs) may affect efficacy.
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Description
This quiz covers the key information about Lisinopril, including its classification, actions, and therapeutic uses for heart failure and hypertension. Test your knowledge on its effectiveness, administration, and off-label uses.
