26 Questions
What is the main reason why lincomycin is rarely used?
Toxicity
Which drug is a chlorine-substituted derivative of lincomycin?
Clindamycin
What is the primary mechanism of action of clindamycin?
Suppression of protein synthesis
Which type of bacteria is primarily susceptible to clindamycin?
Gram-positive only
Apart from gram-positive bacteria, clindamycin is also effective against which pathogens?
Bacteroides
In what type of patients does clindamycin play a significant role in treating infections?
Penicillin-allergic patients
Which type of infections is clindamycin recommended as a second- or third-line therapy for?
Respiratory infections
For which population is clindamycin indicated due to potential harm or intolerance to first-line agents?
Pregnant women and children
What is the first-line therapy recommended for odontogenic (dental) infections?
Clindamycin
Why should patients with a history of colitis or those who poorly tolerate colitis probably not receive clindamycin?
Associated with a high incidence of Clostridium difficile infection (CDI)
Which population should be closely monitored due to the risk of developing an allergic response to some oral clindamycin formulations?
Patients with asthma or aspirin allergy
What should be done if significant diarrhea occurs during clindamycin therapy?
Discontinue the drug
In what situation can therapy with clindamycin continue even if significant diarrhea occurs?
If the original infection is severe and alternative antibiotics cannot be used
What strategy can be used to promote adherence to clindamycin therapy due to its multiple daily doses requirement?
"Plan mnemonic or other strategies to promote adherence"
"Because clindamycin has a narrow spectrum of aerobic activity and lacks activity against H.influenzae, it cannot be substituted for other agents typically used to treat URIs." What concept does this statement highlight?
"Narrow spectrum of activity"
"Because some oral clindamycin formulations contain tartrazine, patients with asthma or aspirin allergy are at risk to develop an allergic response." What aspect of patient education does this statement emphasize?
"Allergies"
Which adverse reaction is the most serious when using clindamycin?
GI-related issues
Why is clindamycin a first-line therapy for several serious infections treated parenterally in the hospital?
For its anaerobic activity
Which type of infection is clindamycin a first-line therapy for when resistance to the drug is low?
MRSA infections
What adverse effect should healthcare providers consider in patients who develop diarrhea after taking clindamycin?
Risk for Clostridium difficile infection
Why is clindamycin usage limited in infants and children?
It is reserved for serious infections when other alternatives are inappropriate
In what types of fluids does clindamycin distribute to with high concentrations?
Pleural and peritoneal fluids
What is the main reason for the prevalence of Clostridium difficile infection as an adverse effect of clindamycin?
C.difficile is resistant to clindamycin
What type of patients should use clindamycin with caution due to their lower tolerance for diarrhea?
'Elderly patients'
What happens if doses of orally administered clindamycin exceed 300 to 450 mg every 6 hours?
Risk of severe gastrointestinal side effects
Why is clindamycin considered a Pregnancy Category B drug?
It crosses the placenta and appears in breast milk, but potential benefits may outweigh risks
Explore the pharmacology of lincosamides, focusing on lincomycin and clindamycin. Learn about their structures, activities, and potential toxicities. Understand why clindamycin has limited indications due to its side effects like severe diarrhea and Clostridioides difficile infection (CDI).
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