Lincosamides Pharmacology Overview
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Questions and Answers

What is the main reason why lincomycin is rarely used?

  • High cost
  • Bad taste
  • Low effectiveness
  • Toxicity (correct)
  • Which drug is a chlorine-substituted derivative of lincomycin?

  • Amoxicillin
  • Clindamycin (correct)
  • Erythromycin
  • Vancomycin
  • What is the primary mechanism of action of clindamycin?

  • Activation of bacterial metabolism
  • Inhibition of DNA replication
  • Inhibition of cell wall synthesis
  • Suppression of protein synthesis (correct)
  • Which type of bacteria is primarily susceptible to clindamycin?

    <p>Gram-positive only</p> Signup and view all the answers

    Apart from gram-positive bacteria, clindamycin is also effective against which pathogens?

    <p>Bacteroides</p> Signup and view all the answers

    In what type of patients does clindamycin play a significant role in treating infections?

    <p>Penicillin-allergic patients</p> Signup and view all the answers

    Which type of infections is clindamycin recommended as a second- or third-line therapy for?

    <p>Respiratory infections</p> Signup and view all the answers

    For which population is clindamycin indicated due to potential harm or intolerance to first-line agents?

    <p>Pregnant women and children</p> Signup and view all the answers

    What is the first-line therapy recommended for odontogenic (dental) infections?

    <p>Clindamycin</p> Signup and view all the answers

    Why should patients with a history of colitis or those who poorly tolerate colitis probably not receive clindamycin?

    <p>Associated with a high incidence of Clostridium difficile infection (CDI)</p> Signup and view all the answers

    Which population should be closely monitored due to the risk of developing an allergic response to some oral clindamycin formulations?

    <p>Patients with asthma or aspirin allergy</p> Signup and view all the answers

    What should be done if significant diarrhea occurs during clindamycin therapy?

    <p>Discontinue the drug</p> Signup and view all the answers

    In what situation can therapy with clindamycin continue even if significant diarrhea occurs?

    <p>If the original infection is severe and alternative antibiotics cannot be used</p> Signup and view all the answers

    What strategy can be used to promote adherence to clindamycin therapy due to its multiple daily doses requirement?

    <p>&quot;Plan mnemonic or other strategies to promote adherence&quot;</p> Signup and view all the answers

    "Because clindamycin has a narrow spectrum of aerobic activity and lacks activity against H.influenzae, it cannot be substituted for other agents typically used to treat URIs." What concept does this statement highlight?

    <p>&quot;Narrow spectrum of activity&quot;</p> Signup and view all the answers

    "Because some oral clindamycin formulations contain tartrazine, patients with asthma or aspirin allergy are at risk to develop an allergic response." What aspect of patient education does this statement emphasize?

    <p>&quot;Allergies&quot;</p> Signup and view all the answers

    Which adverse reaction is the most serious when using clindamycin?

    <p>GI-related issues</p> Signup and view all the answers

    Why is clindamycin a first-line therapy for several serious infections treated parenterally in the hospital?

    <p>For its anaerobic activity</p> Signup and view all the answers

    Which type of infection is clindamycin a first-line therapy for when resistance to the drug is low?

    <p>MRSA infections</p> Signup and view all the answers

    What adverse effect should healthcare providers consider in patients who develop diarrhea after taking clindamycin?

    <p>Risk for Clostridium difficile infection</p> Signup and view all the answers

    Why is clindamycin usage limited in infants and children?

    <p>It is reserved for serious infections when other alternatives are inappropriate</p> Signup and view all the answers

    In what types of fluids does clindamycin distribute to with high concentrations?

    <p>Pleural and peritoneal fluids</p> Signup and view all the answers

    What is the main reason for the prevalence of Clostridium difficile infection as an adverse effect of clindamycin?

    <p>C.difficile is resistant to clindamycin</p> Signup and view all the answers

    What type of patients should use clindamycin with caution due to their lower tolerance for diarrhea?

    <p>'Elderly patients'</p> Signup and view all the answers

    What happens if doses of orally administered clindamycin exceed 300 to 450 mg every 6 hours?

    <p>Risk of severe gastrointestinal side effects</p> Signup and view all the answers

    Why is clindamycin considered a Pregnancy Category B drug?

    <p>It crosses the placenta and appears in breast milk, but potential benefits may outweigh risks</p> Signup and view all the answers

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