Podcast
Questions and Answers
A patient presents with a skin infection suspected to be caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Considering the antibiotic's mechanism and spectrum of activity, which of the following would be the MOST appropriate treatment?
A patient presents with a skin infection suspected to be caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Considering the antibiotic's mechanism and spectrum of activity, which of the following would be the MOST appropriate treatment?
- Clindamycin (correct)
- Ciprofloxacin
- Amoxicillin
- Vancomycin
A patient is diagnosed with a severe anaerobic infection above the diaphragm. Which of the following antibiotics would be the MOST suitable initial treatment, considering its spectrum of activity and clinical indication?
A patient is diagnosed with a severe anaerobic infection above the diaphragm. Which of the following antibiotics would be the MOST suitable initial treatment, considering its spectrum of activity and clinical indication?
- Gentamicin
- Metronidazole
- Vancomycin
- Clindamycin (correct)
What is the primary mechanism by which bacteria develop resistance to clindamycin?
What is the primary mechanism by which bacteria develop resistance to clindamycin?
- Methylation at the ribosome binding site. (correct)
- Mutation in DNA gyrase.
- Increased production of beta-lactamase enzymes.
- Efflux pump activity
Which of the following side effects is MOST closely associated with the use of clindamycin?
Which of the following side effects is MOST closely associated with the use of clindamycin?
A patient who is prescribed clindamycin develops severe diarrhea and abdominal pain. Stool studies confirm the presence of Clostridium difficile infection. Which of the following antibiotics would be MOST appropriate for treating this secondary infection?
A patient who is prescribed clindamycin develops severe diarrhea and abdominal pain. Stool studies confirm the presence of Clostridium difficile infection. Which of the following antibiotics would be MOST appropriate for treating this secondary infection?
A microbiology lab reports that a Staphylococcus epidermidis isolate from a patient's blood culture is coagulase-negative and sensitive to clindamycin. What does this suggest regarding treatment options?
A microbiology lab reports that a Staphylococcus epidermidis isolate from a patient's blood culture is coagulase-negative and sensitive to clindamycin. What does this suggest regarding treatment options?
In comparing clindamycin and metronidazole, which statement accurately describes their differing clinical applications?
In comparing clindamycin and metronidazole, which statement accurately describes their differing clinical applications?
After a course of clindamycin, a patient complains of persistent diarrhea but tests negative for Clostridium difficile. What is the MOST appropriate next step in managing this patient?
After a course of clindamycin, a patient complains of persistent diarrhea but tests negative for Clostridium difficile. What is the MOST appropriate next step in managing this patient?
A patient with a known allergy to macrolides is prescribed clindamycin for a Streptococcus pneumoniae infection. Which aspect of clindamycin's mechanism of action is MOST relevant to consider in this scenario?
A patient with a known allergy to macrolides is prescribed clindamycin for a Streptococcus pneumoniae infection. Which aspect of clindamycin's mechanism of action is MOST relevant to consider in this scenario?
If a bacterial strain exhibits resistance to both erythromycin and clindamycin, which mechanism is MOST likely responsible for this cross-resistance?
If a bacterial strain exhibits resistance to both erythromycin and clindamycin, which mechanism is MOST likely responsible for this cross-resistance?
Flashcards
Lincosamides Mechanism
Lincosamides Mechanism
Antibiotics that inhibit bacterial protein synthesis by blocking peptide bond formation, leading to a bacteriostatic effect.
Lincosamides Spectrum
Lincosamides Spectrum
Community-acquired MRSA, coagulase-negative staph, Streptococcus pneumoniae, and anaerobic bacteria like Bacteroides and Clostridium perfringens.
Lincosamides Resistance
Lincosamides Resistance
Through methylation at the ribosome binding site.
Lincosamides Side Effects
Lincosamides Side Effects
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Clindamycin
Clindamycin
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Clindamycin Use (Above Diaphragm)
Clindamycin Use (Above Diaphragm)
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Study Notes
- Lincosamides are a class of antibiotics.
- Clindamycin is a specific antibiotic in this class
Mechanism
- Lincosamides block peptide bond formation.
- They are bacteriostatic.
Spectrum of Activity
- Effective against community-acquired MRSA and Staph epi (coag -).
- Effective against Streptococcus pneumoniae.
- Lincosamides treat anaerobic infections, including Bacteroides species and Clostridium perfringens.
- These treat anaerobic infections above the diaphragm, whereas metronidazole treats those below the diaphragm
Resistance
- Resistance to lincosamides develops through methylation at the ribosome binding site.
Side Effects
- Diarrhea is a common side effect.
- Can cause Clostridium difficile colitis, also known as pseudomembranous colitis, with the highest incidence among antibiotics.
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