Limited Role of F-18 FDG PET/CT in Certain Cancers

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Which type of cancer is only 50% imaged with FDG-PET due to high levels of phosphatase?

Hepatocellular carcinoma (HCC)

What percentage of renal cell carcinomas are FDG-avid?


Why is detection of ureteral or bladder lesions extremely limited with FDG-PET?

Due to surrounding high urinary FDG activity

In which type of prostate cancer is FDG-PET reserved for assessing treatment response?

Aggressive castration-resistant prostate cancer

What type of tumors tend to have low FDG uptake or are non-FDG-avid?

Well-differentiated or mucinous cell type tumors, lung adenocarcinoma, and carcinoid tumors

What is the new first-line diagnostic imaging modality for neuroendocrine tumors?

Gallium-68 DOTATATE (GaTate) PET/CT

What is the primary benefit of using DOTATATE and FDG PET/CT in tandem?

To provide a comprehensive view of both well-differentiated and poorly differentiated tumors

Which of the following PET radiotracers is FDA-approved for imaging biochemically recurrent prostate cancer with high PSA levels?

Carbon-11/F-18 choline

What is the primary mechanism of F-18 fluciclovine (Axumin) in prostate cancer imaging?

Targeting amino acid transporters

Which PET radiotracer is highly sensitive for the detection of prostate cancer bone metastases?

F-18 sodium fluoride (F-18 NaF)

What is the limitation of F-18 sodium fluoride (F-18 NaF) in prostate cancer imaging?

Both A and B

What is the primary characteristic of Tc-99m DTPA and Tc-99m pertechnetate?

They are transient perfusion agents

This quiz covers the types of cancers where F-18 FDG PET/CT imaging has limited diagnostic value, including Hepatocellular carcinoma, Renal cell carcinoma, and bladder cancer. Understand the reasons behind the limitations of FDG-PET in these cancers. Test your knowledge and learn more about the role of PET/CT in cancer diagnosis.

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