Limited Role of F-18 FDG PET/CT in Certain Cancers
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Questions and Answers

Which type of cancer has only 50% of its cases that can be imaged with FDG-PET due to high levels of phosphatase?

  • Renal cell carcinoma
  • Hepatocellular carcinoma (correct)
  • Prostate cancer
  • Bladder cancer

What is the main limitation of using FDG-PET for detecting ureteral or bladder lesions?

  • High urinary FDG activity (correct)
  • Low FDG uptake by the tumor
  • Low sensitivity of FDG-PET for these types of tumors
  • High levels of phosphatase in the tumor

What is the primary role of FDG-PET in prostate cancer?

  • Monitoring treatment response in localized prostate cancer
  • Assessing treatment response of bony metastases in aggressive castration-resistant prostate cancer (correct)
  • Screening for prostate cancer in high-risk populations
  • Initial diagnosis of prostate cancer

Which type of tumor tends to have low FDG uptake or is non-FDG-avid?

<p>Well-differentiated or mucinous cell type tumors (A)</p> Signup and view all the answers

What is the half-life of Gallium-68, a generator-produced positron emitter?

<p>68 minutes (A)</p> Signup and view all the answers

What is the new first-line diagnostic imaging modality for neuroendocrine tumors?

<p>DOTATATE PET/CT (B)</p> Signup and view all the answers

What is the characteristic of DOTATATE uptake in tumors?

<p>High uptake in well-differentiated tumors (C)</p> Signup and view all the answers

Which PET radiotracer is FDA-approved for detection of biochemically recurrent prostate cancer?

<p>F-18 fluciclovine (Axumin) (A)</p> Signup and view all the answers

What is the characteristic of F-18 sodium fluoride (F-18 NaF) in detecting prostate cancer bone metastases?

<p>High sensitivity and low specificity (D)</p> Signup and view all the answers

What is the common feature of Tc-99m DTPA and Tc-99m pertechnetate?

<p>They are transient perfusion agents (D)</p> Signup and view all the answers

Why is imaging performed immediately after injection of F-18 fluciclovine (Axumin)?

<p>To limit any significant urinary excretion (C)</p> Signup and view all the answers

What is the enzymatic modification required for Tc-99m ECD?

<p>To be retained in the cell (A)</p> Signup and view all the answers

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