Lifitegrast (Xiidra) Mechanism and Side Effects
35 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main anti-inflammatory mechanism of Lifitegrast (Xiidra)?

  • Stimulation of cytokine secretion
  • Inhibition of conjunctival cell apoptosis and T cell apoptosis (correct)
  • Activation of LFA-1 on leukocytes
  • Presence of surfactant and oil for better tolerability

Why does Lifitegrast (Xiidra) have better tolerability and less vision disturbances?

  • It contains LFA-1 antagonist
  • It activates ICAM-1 on DED cornea/conjunctiva
  • It stimulates cytokine secretion
  • It has no surfactant or oil (correct)

Which receptor does Lifitegrast (Xiidra) bind to in order to inhibit cytokine secretion?

  • ICAM-1
  • Tetracycline
  • LFA-1 (correct)
  • Matrix metalloproteinases

What is the main side effect associated with Lifitegrast (Xiidra)?

<p>Dysgeusia (change in taste) (D)</p> Signup and view all the answers

What is the chemical produced naturally as an element of the immune response during oxidative burst?

<p>Hypochlorous acid (D)</p> Signup and view all the answers

What is the main action of mucolytics such as Acetylcysteine?

<p>Softening mucous and affecting goblet cells (A)</p> Signup and view all the answers

What is the main use of tetracycline in the context provided?

<p>Inhibiting Matrix metalloproteinases (D)</p> Signup and view all the answers

What is the main caution associated with Omega 3 (Hydroeye) in patients on blood thinners?

<p>May affect clotting time by decreasing platelet aggregation – therefore use with caution and appropriate co-management with clotting time monitored with patients on blood thinners (C)</p> Signup and view all the answers

What is the main function of Avenova?

<p>Removes bacteria and debris on eyelid (D)</p> Signup and view all the answers

What is the mechanism of action of cyclosporine?

<p>Inhibits apoptosis of conjunctival epithelial cells (A)</p> Signup and view all the answers

Which of the following is a serious adverse reaction associated with systemic cyclosporine?

<p>Gingival hyperplasia (C)</p> Signup and view all the answers

What is the main purpose of Restasis (0.05%)?

<p>To increase tear production in certain conditions (A)</p> Signup and view all the answers

What is the expected timeline for significant improvement when using Restasis (0.05%)?

<p>&gt;6 months (A)</p> Signup and view all the answers

When is the use of Restasis (0.05%) contraindicated?

<p>In the presence of ocular infection (B)</p> Signup and view all the answers

What is the key feature of Cequa (0.09%)?

<p>Nanomicellar technology (C)</p> Signup and view all the answers

For which conditions is Cequa (0.09%) used?

<p>Vernal keratoconjunctivitis (VKC) (B)</p> Signup and view all the answers

What distinguishes Vervazia (0.1%) from other topical treatments?

<p>It is an emulsion (C)</p> Signup and view all the answers

What may be the effect of EPA and DHA on prothrombin time and bleeding?

<p>Increase prothrombin time and bleeding (C)</p> Signup and view all the answers

What was the outcome of the DREAM study regarding the use of omega 3 fatty acids for the treatment of DED?

<p>Omega 3 was no better than olive oil (A)</p> Signup and view all the answers

What is a consideration related to the use of omega 3?

<p>May decrease effect of BP meds (C)</p> Signup and view all the answers

Which condition may lead to neurotrophic keratitis?

<p>Use of contact lenses (B)</p> Signup and view all the answers

What is the interplay that contributes to corneal homeostasis?

<p>Corneal nerves and epithelial cells (D)</p> Signup and view all the answers

What is the most common cause of neurotrophic keratitis?

<p>Herpes keratitis (B)</p> Signup and view all the answers

Which treatment is NOT recommended for neurotrophic keratitis?

<p>Use of oral antibiotics (D)</p> Signup and view all the answers

What is Oxervate?

<p>An FDA-approved treatment for neurotrophic keratitis (D)</p> Signup and view all the answers

What is the source of Oxervate?

<p>Recombinant bacteria-derived human growth factor (A)</p> Signup and view all the answers

What is considered an important step before starting omega 3 treatment?

<p>Obtaining baseline omega 3 level prior to treatment (C)</p> Signup and view all the answers

What is the main purpose of Tear Conservation?

<p>To obstruct lacrimal drainage through surgery and cautery (B)</p> Signup and view all the answers

Which method is recommended to address tear obstruction for people with aqueous deficiency and ocular surface problems?

<p>UltraPlug Extended Wear Synthetic Absorbable Plug (C)</p> Signup and view all the answers

Why is it cautioned against using silicone plugs in individuals with dacryocystitis?

<p>Silicone plugs are difficult to remove with irrigation (D)</p> Signup and view all the answers

What is the main difference between collagen rods and UltraPlug Extended Wear Synthetic Absorbable Plugs?

<p>Collagen rods dissolve within 2-6 months, while UltraPlug is temporary (D)</p> Signup and view all the answers

What is the purpose of Dextenza, a punctal plug releasing dexamethasone?

<p>To reduce inflammatory mediators in the tear film (A)</p> Signup and view all the answers

What distinguishes Smart plugs from other types of punctal plugs?

<p>They are removed by probe or irrigation (B)</p> Signup and view all the answers

What is the drawback of using Freeman plugs?

<p>They are prone to high probability of plug loss (B)</p> Signup and view all the answers

Why is Tarsorrhaphy not recommended for individuals with an inflammatory etiology to dry eye?

<p>It worsens the inflammatory response by causing pooling of mediators (B)</p> Signup and view all the answers
Use Quizgecko on...
Browser
Browser