Lifespan of Leukocytes Quiz
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Questions and Answers

What is the primary function of platelets?

  • To prevent excessive internal or external bleeding (correct)
  • To produce white blood cells
  • To regulate blood pressure
  • To transport oxygen in the blood

    • Where are platelet granules found?

  • In the bone marrow
  • In the white blood cells
  • In the megakaryocyte cytoplasm (correct)
  • In the red blood cells

    • What triggers the activation of platelets?

  • Exposure to collagen of basal lamina and connective tissue (correct)
  • Exposure to glucose
  • Exposure to oxygen
  • Exposure to nitrogen

    • How do platelets help in wound repair?

    <p>By secreting chemicals like platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF beta)</p> Signup and view all the answers

    What is the typical lifespan of platelets?

    <p>About 10 days</p> Signup and view all the answers

    What is the size of platelets?

    <p>2-4 um in diameter</p> Signup and view all the answers

    Which substance promotes adhesion of platelets to endothelial cells?

    <p>VON WILLEBRAND FACTOR</p> Signup and view all the answers

    What do platelets primarily help to form after an injury?

    <p>Blood clots</p> Signup and view all the answers

    What do platelet granules contain?

    <p>VON WILLEBRAND FACTOR and PLATELET FACTOR IV</p> Signup and view all the answers

    What triggers the activation of platelets?

    <p>Exposure to collagen of basal lamina and connective tissue</p> Signup and view all the answers

    Which of the following is a primary lymphoid organ?

    <p>Thymus</p> Signup and view all the answers

    Which structure is responsible for the maturation of B lymphocytes?

    <p>Bone marrow</p> Signup and view all the answers

    What is the function of high endothelial venules (HEVs) in the lymphatic system?

    <p>Lymphocyte migration</p> Signup and view all the answers

    Which cell type is responsible for antigen presentation in the lymphatic system?

    <p>Dendritic cell</p> Signup and view all the answers

    What is the clinical significance of thymic involution?

    <p>Reduced immune response</p> Signup and view all the answers

    Which types of epithelioreticular cells are present in the thymus cortex?

    <p>Type I, Type II, and Type III</p> Signup and view all the answers

    What is the structural feature of the thymus that establishes domains called thymic lobules?

    <p>Trabeculae</p> Signup and view all the answers

    What is the function of Type VI epithelioreticular cells in the thymus?

    <p>Production of thymosin and thymopoietin</p> Signup and view all the answers

    What process ensures that surviving lymphocytes in the thymus are responsive to appropriate stimuli and not self-reactive?

    <p>Negative selection</p> Signup and view all the answers

    What clinical condition is caused by the failure of epithelioreticular cells to develop T cell precursors in the thymus?

    <p>DiGeorge Syndrome</p> Signup and view all the answers

    Where are lymphatic nodules primarily found?

    <p>Large intestine</p> Signup and view all the answers

    What is the function of high endothelial venules (HEVs) in the lymph nodes?

    <p>Transport antigens</p> Signup and view all the answers

    What is the main difference between primary and secondary lymphatic nodules?

    <p>Presence of germinal centers</p> Signup and view all the answers

    Which organ was once thought to be vestigial but actually contains large numbers of lymphatic nodules?

    <p>Appendix</p> Signup and view all the answers

    What is the function of M cells in Peyer's patches?

    <p>Present antigens to T cells</p> Signup and view all the answers

    Where do T lymphocytes migrate to after leaving the HEV in the lymph node?

    <p>Outer cortex</p> Signup and view all the answers

    What is the function of stave cells in the red pulp of the spleen?

    <p>Phagocytosis of RBCs</p> Signup and view all the answers

    What is the role of periarterial lymphatic sheath (PALS) in the spleen?

    <p>Monitoring blood-borne antigens</p> Signup and view all the answers

    What is the main function of splenic sinuses in the red pulp?

    <p>Traversal of healthy RBCs</p> Signup and view all the answers

    Where do B lymphocytes encounter blood-borne antigens in the spleen?

    <p>Red pulp</p> Signup and view all the answers

    Where are the high endothelial venules (HEVs) located?

    <p>In the deep cortex of the lymph node</p> Signup and view all the answers

    What is the main function of M cells in Peyer's patches?

    <p>Transporting antigens from the intestine to immune cells</p> Signup and view all the answers

    Where are lymphatic nodules typically found?

    <p>Along lymphatic vessels</p> Signup and view all the answers

    What triggers activation of platelets?

    <p>Adhesion to collagen</p> Signup and view all the answers

    What is the exact function of the appendix?

    <p>The exact function remains unclear</p> Signup and view all the answers

    What is the clinical significance of DiGeorge Syndrome?

    <p>It causes failure of epithelioreticular cells to develop T cell precursors in the thymus</p> Signup and view all the answers

    What is the main function of Hassall’s corpuscles in the thymus?

    <p>Maturation of T lymphocytes</p> Signup and view all the answers

    Where are PALs (periarteriolar lymphatic sheaths) located?

    <p>In the white pulp of the spleen</p> Signup and view all the answers

    What is the primary function of MALT (mucosa associated lymphoid tissue)?

    <p>Defense against gastrointestinal pathogens</p> Signup and view all the answers

    What triggers the activation of platelets?

    <p>Exposure to collagen or tissue factor</p> Signup and view all the answers

    What is the main function of type V epithelioreticular cells in the thymus?

    <p>Deletion of self-reactive T cells</p> Signup and view all the answers

    What is the main function of type II epithelioreticular cells in the thymus cortex?

    <p>Antigen presentation to immature lymphocytes</p> Signup and view all the answers

    What is the structural feature responsible for creating 'privileged' areas for T cell development in the thymus?

    <p>Continuous (non-fenestrated) endothelium</p> Signup and view all the answers

    Which type of epithelioreticular cells is involved in forming a cytoplasmic reticulum within the thymus parenchyma?

    <p>Type I epithelioreticular cells</p> Signup and view all the answers

    What is the function of Hassall's corpuscles in the thymus?

    <p>Production of lymphocytes maturation factors</p> Signup and view all the answers

    Where do B lymphocytes encounter blood-borne antigens in the spleen?

    <p>Red pulp</p> Signup and view all the answers

    What is the main function of high endothelial venules (HEVs) in the lymph nodes?

    <p>Migration of lymphocytes from the blood into the lymph node</p> Signup and view all the answers

    What is the primary function of platelets?

    <p>Promoting blood coagulation</p> Signup and view all the answers

    What is the clinical significance of thymic involution?

    <p>Increased risk of autoimmune diseases</p> Signup and view all the answers

    What process ensures that surviving lymphocytes in the thymus are responsive to appropriate stimuli and not self-reactive?

    <p>Negative selection</p> Signup and view all the answers

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