5 Questions
What is the clinical significance of hypersegmented neutrophils?
Megaloblastic anemia
What is the characteristic morphology of hyposegmented granulocyte nuclei in Pelger-Huet anomaly?
Round or ovoid
What is the clinical significance of LE cells?
Presence of anti-nuclear antibodies and cell nuclei
What disorder is associated with Alder-Reilly granules?
Mucopolysaccharidosis type I
What is the clinical significance of Auer rods?
Acute myeloid leukemia
Study Notes
Neutrophil Abnormalities
- Hypersegmented neutrophils are a clinical indicator of megaloblastic anemia, often seen in vitamin B12 or folate deficiency.
- Hyposegmented granulocyte nuclei in Pelger-Huet anomaly have a characteristic "pince-nez" or "spectacle" shape due to nuclear hyposegmentation.
- LE cells, a type of neutrophil, are a clinical indicator of lupus erythematosus, an autoimmune disease.
- Alder-Reilly granules are associated with May-Hegglin anomaly, a rare genetic disorder characterized by thrombocytopenia and giant platelets.
- Auer rods, found in myeloid cells, are a clinical indicator of acute myeloid leukemia (AML), particularly in the M3 subtype.
Test your knowledge of leukocyte abnormalities and non-malignant WBC disorders, focusing on leukocyte morphological abnormalities including granulocytes nuclear and cytoplasmic abnormalities, reactive changes, and more.
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