Podcast
Questions and Answers
What is the clinical significance of hypersegmented neutrophils?
What is the clinical significance of hypersegmented neutrophils?
What is the characteristic morphology of hyposegmented granulocyte nuclei in Pelger-Huet anomaly?
What is the characteristic morphology of hyposegmented granulocyte nuclei in Pelger-Huet anomaly?
What is the clinical significance of LE cells?
What is the clinical significance of LE cells?
What disorder is associated with Alder-Reilly granules?
What disorder is associated with Alder-Reilly granules?
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What is the clinical significance of Auer rods?
What is the clinical significance of Auer rods?
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Study Notes
Neutrophil Abnormalities
- Hypersegmented neutrophils are a clinical indicator of megaloblastic anemia, often seen in vitamin B12 or folate deficiency.
- Hyposegmented granulocyte nuclei in Pelger-Huet anomaly have a characteristic "pince-nez" or "spectacle" shape due to nuclear hyposegmentation.
- LE cells, a type of neutrophil, are a clinical indicator of lupus erythematosus, an autoimmune disease.
- Alder-Reilly granules are associated with May-Hegglin anomaly, a rare genetic disorder characterized by thrombocytopenia and giant platelets.
- Auer rods, found in myeloid cells, are a clinical indicator of acute myeloid leukemia (AML), particularly in the M3 subtype.
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Description
Test your knowledge of leukocyte abnormalities and non-malignant WBC disorders, focusing on leukocyte morphological abnormalities including granulocytes nuclear and cytoplasmic abnormalities, reactive changes, and more.
