Leukocyte Abnormalities and Disorders

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Questions and Answers

What is the clinical significance of hypersegmented neutrophils?

Megaloblastic anemia (correct)
Chediak-Higashi syndrome
Ehlers-Danlos syndrome
Myelodysplastic syndrome

What is the characteristic morphology of hyposegmented granulocyte nuclei in Pelger-Huet anomaly?

Star-shaped
Square
Triangular
Round or ovoid (correct)

What is the clinical significance of LE cells?

Syndrome X
Presence of anti-nuclear antibodies and cell nuclei (correct)
Glanzmann thrombasthenia
Reactive lymphocyte formation

What disorder is associated with Alder-Reilly granules?

<p>Mucopolysaccharidosis type I (A)</p> Signup and view all the answers

What is the clinical significance of Auer rods?

<p>Acute myeloid leukemia (A)</p> Signup and view all the answers

Flashcards

Hypersegmented neutrophils

Neutrophils with more than five nuclear lobes, often a sign of megaloblastic anemia.

Pelger-Huet anomaly

Genetic disorder causing round or ovoid nuclei in granulocytes.

LE cells

Cells with a characteristic appearance, indicating anti-nuclear antibodies and cell nuclei.

Alder-Reilly granules

Granules associated with mucopolysaccharidoses.

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Auer rods

Rod-shaped structures, indicative of acute myeloid leukemia.

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Study Notes

Neutrophil Abnormalities

Hypersegmented neutrophils are a clinical indicator of megaloblastic anemia, often seen in vitamin B12 or folate deficiency.
Hyposegmented granulocyte nuclei in Pelger-Huet anomaly have a characteristic "pince-nez" or "spectacle" shape due to nuclear hyposegmentation.
LE cells, a type of neutrophil, are a clinical indicator of lupus erythematosus, an autoimmune disease.
Alder-Reilly granules are associated with May-Hegglin anomaly, a rare genetic disorder characterized by thrombocytopenia and giant platelets.
Auer rods, found in myeloid cells, are a clinical indicator of acute myeloid leukemia (AML), particularly in the M3 subtype.

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Description

Test your knowledge of leukocyte abnormalities and non-malignant WBC disorders, focusing on leukocyte morphological abnormalities including granulocytes nuclear and cytoplasmic abnormalities, reactive changes, and more.